149256.fig.008a
(a)
149256.fig.008b
(b)
Figure 8: Synthesis and degradation of dopamine, norepinephrine, and serotonin. The detailed pathway of the synthesis and degradation of dopamine, norepinepherine (a) and serotonin (b) were shown. The arrows indicate the up- and downregulation of the corresponding mRNA level by the treatment of KXS. TH: tyrosine hydroxylase; AADC: aromatic acid decarboxylase; MAOB: monoamine oxidase B; COMT: catechol-O-methyl-transferase; DOPAC: dihydroxyphenylacetic acid; 3-MT: 3-methoxytyramine; DBH: dopamine β-hydroxylase; DOPEG: dihydroxyphenylglycol; NM: normetanephrine; TPH: tryptophan hydroxylase; 5-HTP: 5-hydroxytryptophan; MAOA: monoamine oxidase A; 5-HIAA: 5-hydroxyindole-3-acetic acid.