Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 149762, 11 pages
http://dx.doi.org/10.1155/2012/149762
Review Article

Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

1School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
2Institute of Basic Research of Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
3School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong
4Institute of Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received 24 September 2012; Accepted 18 October 2012

Academic Editor: Shao Li

Copyright © 2012 Jian Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [35 citations]

The following is the list of published articles that have cited the current article.

  • J. M. Harrold, and M. Ramanathan, “Network-Based Approaches in Drug Discovery and Early Development,” Clinical Pharmacology & Therapeutics, vol. 94, no. 6, pp. 651–658, 2013. View at Publisher · View at Google Scholar
  • Jiangyong Gu, Yuanshen Gui, Lirong Chen, Gu Yuan, and Xiaojie Xu, “CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology,” Journal of Cheminformatics, vol. 5, 2013. View at Publisher · View at Google Scholar
  • Wei-Xia Li, Yu-Ping Tang, Shu-Lan Su, Pei Liu, Jian-Ming Guo, Er-Xin Shang, Da-Wei Qian, and Jin-Ao Duan, “Study on Chinese medicine pairs (V)-their modern research strategies and approaches,” Zhongguo Zhongyao Zazhi, vol. 38, no. 24, pp. 4208–4213, 2013. View at Publisher · View at Google Scholar
  • Xuan Liu, Wan-Ying Wu, Bao-Hong Jiang, Min Yang, and De-An Guo, “Pharmacological tools for the development of traditional Chinese medicine,” Trends in Pharmacological Sciences, 2013. View at Publisher · View at Google Scholar
  • Jiangyong Gu, Lirong Chen, Gu Yuan, and Xiaojie Xu, “A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Xingjiang Xiong, Xiaochen Yang, Wei Liu, Fuyong Chu, Pengqian Wang, and Jie Wang, “Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–13, 2013. View at Publisher · View at Google Scholar
  • Zhan Zheng, William Chi-Shing Cho, Ling Xu, Juyong Wang, and Daniel Man-Yuen Sze, “Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Ming Yang, Jia-Lei Chen, Li-Wen Xu, and Guang Ji, “Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–23, 2013. View at Publisher · View at Google Scholar
  • Shulan Su, Jinao Duan, Wenxia Cui, Erxing Shang, Pei Liu, Gang Bai, Sheng Guo, Dawei Qian, and Yuping Tang, “Network-Based Biomarkers for Cold Coagulation Blood Stasis Syndrome and the Therapeutic Effects of Shaofu Zhuyu Decoction in Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–15, 2013. View at Publisher · View at Google Scholar
  • Xi-Wen Li, Guo-Sheng Wu, Jia-Jie Guo, Jiao-Lin Bao, Xiu-Ping Chen, Jin-Jian Lu, and Yi-Tao Wang, “Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum - a review,” Expert Opinion On Investigational Drugs, vol. 22, no. 8, pp. 981–992, 2013. View at Publisher · View at Google Scholar
  • Da Cheng Hao, and Pei Gen Xiao, “Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine,” Drug Development Research, vol. 75, no. 5, pp. 299–312, 2014. View at Publisher · View at Google Scholar
  • Hsing-Yu Chen, Ben-Shian Huang, Yi-Hsuan Lin, Irene H. Su, Sien-Hung Yang, Jiun-Liang Chen, Jen-Wu Huang, and Yu-Chun Chen, “Identifying Chinese herbal medicine for premenstrual syndrome: implications from a nationwide database,” Bmc Complementary and Alternative Medicine, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Shengnan Han, Yan Li, Jianlan Jiang, and Xiaohang Zhang, “Development of a multi-component drug from turmeric using central composite design,” Frontiers of Chemical Science and Engineering, vol. 8, no. 3, pp. 362–368, 2014. View at Publisher · View at Google Scholar
  • Xinzhuang Zhang, Jiangyong Gu, Liang Cao, Na Li, Yiming Ma, Zhenzhen Su, Gang Ding, Lirong Chen, Xiaojie Xu, and Wei Xiao, “Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection,” Molecular Biosystems, vol. 10, no. 10, pp. 2517–2525, 2014. View at Publisher · View at Google Scholar
  • Yanfeng Liu, Pengcheng He, Xiaoyan Cheng, and Mei Zhang, “Long-term outcome of 31 cases of refractory acute promyelocytic leukemia treated with compound realgar natural indigo tablets administered alternately,” Oncology Letters, vol. 10, no. 2, pp. 1184–1190, 2015. View at Publisher · View at Google Scholar
  • Uma Chandran, Neelay Mehendale, Girish Tillu, and Bhushan Patwardhan, “Network pharmacology: An emerging technique for natural product drug discovery and scientific research on ayurveda,” Proceedings of the Indian National Science Academy, vol. 81, no. 3, pp. 561–568, 2015. View at Publisher · View at Google Scholar
  • Asjad Ali, Sun Woong Bang, Sang-Min Chung, and Jack E. Staub, “Plant Transformation via Pollen Tube-Mediated Gene Transfer,” Plant Molecular Biology Reporter, vol. 33, no. 3, pp. 742–747, 2015. View at Publisher · View at Google Scholar
  • Miao Jiang, Qinglin Zha, Chi Zhang, Cheng Lu, Xiaoping Yan, Wanhua Zhu, Wei Liu, Shenghao Tu, Liping Hou, Chengwu Wang, Wandong Zhang, Qinghua Liang, Bing Fan, Jiangping Yu, Weidong Zhang, Xinru Liu, Jing Yang, Xiaojuan He, Li Li, Xuyan Niu, Yan Liu, Hongtao Guo, Bing He, Ge Zhang, Zhaoxiang Bian, and Aiping Lu, “Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial,” Scientific Reports, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Jianglong Song, Shihuan Tang, Xi Liu, Yibo Gao, Hongjun Yang, and Peng Lu, “A Modularity-Based Method Reveals Mixed Modules from Chemical-Gene Heterogeneous Network,” Plos One, vol. 10, no. 4, 2015. View at Publisher · View at Google Scholar
  • Rolf Teschke, Albrecht Wolff, Christian Frenzel, Axel Eickhoff, and Johannes Schulze, “Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders,” World Journal Of Gastroenterology, vol. 21, no. 15, pp. 4466–4490, 2015. View at Publisher · View at Google Scholar
  • Jin-Bin Wei, Xiong Li, Hui Song, Yong-Hong Liang, Yu-Zheng Pan, Jun-Xiang Ruan, Xia Qin, Yong-Xin Chen, Cal-Li Nong, and Zhi-Heng Su, “Characterization and determination of antioxidant components in the leaves of Camellia chrysantha (Hu) Tuyama based on composition-activity relationsh,” Journal Of Food And Drug Analysis, vol. 23, no. 1, pp. 40–48, 2015. View at Publisher · View at Google Scholar
  • Shao Zhongxing, Lei Guilan, Cheng Jia, Zhang Guangqin, Tang Xiaoping, Zhan Xianfeng, and Ye Dongyun, “Therapeutic effects of traditional Chinese medicine in patients with symptomatic cervical ectopy,” Complementary Therapies In Medicine, vol. 23, no. 6, pp. 816–820, 2015. View at Publisher · View at Google Scholar
  • Wenna Nie, Yana Lv, Leyu Yan, Xi Chen, and Haitao Lv, “Prediction and Characterisation of the System Effects of Aristolochic Acid: A Novel Joint Network Analysis towards Therapeutic and Toxicological Mecha,” Scientific Reports, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Gregory R. Johnson, Jieyue Li, Aabid Shariff, Gustavo K. Rohde, and Robert F. Murphy, “Automated Learning of Subcellular Variation among Punctate Protein Patterns and a Generative Model of Their Relation to Microtubules,” Plos Computational Biology, vol. 11, no. 12, 2015. View at Publisher · View at Google Scholar
  • Xiao-Jia Chen, Zheng-Hai Tang, Xi-Wen Li, Cai-Xiang Xie, Jin-Jian Lu, and Yi-Tao Wang, “Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo),” American Journal Of Chinese Medicine, vol. 43, no. 5, pp. 783–834, 2015. View at Publisher · View at Google Scholar
  • Rolf Teschke, and Axel Eickhoff, “Herbal hepatotoxicity in traditional and modern medicine: Actual key issues and new encouraging steps,” Frontiers in Pharmacology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Jing Sun, Li Zhang, Yujun He, Yongsheng Fan, Zhijun Xie, Kun Zhang, and Liping Wu, “To unveil the molecular mechanisms of Qi and blood through systems biology-based investigation into Si-Jun-Zi-Tang and Si-Wu-Tang formulae,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Wei Zhou, Wen-Feng Yuan, Chao Chen, Shu-Mei Wang, and Sheng-Wang Liang, “Study on material base and action mechanism of compound Danshen dripping pills for treatment of atherosclerosis based on modularity analysis,” Journal of Ethnopharmacology, 2016. View at Publisher · View at Google Scholar
  • Moon Hee Lee, Sang Hoon Hong, Yung Hyun Choi, Cheol Park, Sun-Hee Leem, Sung Hyun Choi, Young-Sam Keum, Jin Won Hyun, Su-Hyun Hong, Gi-Young Kim, and Taeg Kyu Kwon, “Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway,” Oncology Reports, vol. 36, no. 1, pp. 205–214, 2016. View at Publisher · View at Google Scholar
  • Fazlul H. Sarkar, “Novel Holistic Approaches for Overcoming Therapy Resistance in Pancreatic and Colon Cancers,” Medical Principles and Practice, vol. 25, no. 2, pp. 3–10, 2016. View at Publisher · View at Google Scholar
  • Xin-Zhuang Zhang, Zhi-Peng Ke, Gang Ding, Wei Xiao, Xiao-Jie Xu, Na Li, Liang Cao, and Zhen-Zhong Wang, “Molecular mechanism of Guizhi Fuling Capsule for treatment of dysmenorrhea, pelvic inflammatory disease, and hysteromyoma via network pharmacology,” Chinese Traditional and Herbal Drugs, vol. 47, no. 1, pp. 81–94, 2016. View at Publisher · View at Google Scholar
  • Haidan Yuan, Qianqian Ma, Heying Cui, Guancheng Liu, Xiaoyan Zhao, Wei Li, and Guangchun Piao, “How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?,” Molecules, vol. 22, no. 7, pp. 1135, 2017. View at Publisher · View at Google Scholar
  • Peng Li, Jianxin Chen, Wuxia Zhang, Bangze Fu, and Wei Wang, “Transcriptome inference and systems approaches to polypharmacology and drug discovery in herbal medicine,” Journal of Ethnopharmacology, vol. 195, pp. 127–136, 2017. View at Publisher · View at Google Scholar
  • Shuo Gu, and Jianfeng Pei, “Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–7, 2017. View at Publisher · View at Google Scholar
  • Yu Mao, Jian Hao, Zi-Qi Jin, Yang-Yang Niu, Xue Yang, Dan Liu, Rui Cao, and Xiong-Zhi Wu, “Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients,” Oncotarget, vol. 8, no. 16, pp. 27007–27021, 2017. View at Publisher · View at Google Scholar