Mitigation of H2O2-Induced Mitochondrial-Mediated Apoptosis in NG108-15 Cells by Novel Mesuagenin C from Mesua kunstleri (King) Kosterm
Mesuagenin C 3 prevented H2O2-induced activation of caspase-3 and caspase-9 in H2O2-treated NG108-15 cells. (a) Representative overlay of histograms showing caspase-3/7-associated immunofluorescence. (b) Bar chart represents dose-dependent reduction in caspase 3/7 activity after pretreatment with mesuagenin C 3. (c) Representative overlay of histograms showing caspase-9-associated immunofluorescence. (d) Bar chart represents dose-dependent reduction in caspase-9 activity after pretreatment with mesuagenin C 3. Values are mean ± S.E. from at least three independent experiments. The asterisk indicated significantly different values from H2O2-treated cells (*).
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