Effects of Vitamin D Supplementation during the Induction and Progression of Osteoarthritis in a Rat Model
Figure 3
Vitamin D reduces the wideness of OA condyles. (a) A representative image of the femoral condyles from a rat with 20 days of OA without treatment. (b) A representative image of the femoral condyles from a rat treated with 4 IU/kg/day of vitamin D. The difference in wideness was taken as an indicator of the degree of severity of OA hypertrophy. (c) The graph presents the average wideness at a given dose from 3 different experiments with 15 total rats. A decrease in the severity of mm (95% CI 0.05367 to 0.4459, ) was determined using a one-way ANOVA with Dunnet’s post hoc test to compare all of the conditions with the control group (OA of 20 days without vitamin D). The error bars indicate the SEM. The scale bar = 1 mm 8x.
