Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy

Table 3

Effects of trigonelline on GLP-1 level in serum and GLP-1R mRNA expression in sciatic nerve.

Group	GLP-1 level in serum (pmol/L)	Sciatic nerve GLP-1R mRNA
Control	19.06 ± 2.65	1.00 ± 0.00
Diabetes	12.42 ± 1.11*	0.49 ± 0.08*
Diabetes + trigonelline	18.90 ± 1.25^#	1.03 ± 0.12^#
Diabetes + sitagliptin	18.27 ± 1.22^#	1.08 ± 0.12^#

ΔCT (threshold cycle) = CT (target gene) − CT (β-actin), ΔΔCT = ΔCT (other rats) −  ΔCT (control rats), relative fold = 2^−ΔΔCT, and control rat is 1. Data are given as mean ± SD, n = 10. *P < 0.01, compared with control rats; ^#P < 0.01, compared with diabetes rats.