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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 173565, 7 pages
http://dx.doi.org/10.1155/2012/173565
Research Article

Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula

1College of Pharmaceutical Sciences, Zhejiang Chinese Medicine University, Hangzhou 310053, China
2School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong

Received 24 April 2012; Revised 27 June 2012; Accepted 4 July 2012

Academic Editor: Karl Wah-Keung Tsim

Copyright © 2012 Zhen Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. J. Nestler, M. Barrot, R. J. DiLeone, A. J. Eisch, S. J. Gold, and L. M. Monteggia, “Neurobiology of depression,” Neuron, vol. 34, no. 1, pp. 13–25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Savegnago, C. R. Jesse, L. G. Pinto, J. B. T. Rocha, C. W. Nogueira, and G. Zeni, “Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 6, pp. 1261–1269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Bilici, H. Efe, M. A. Köroǧlu, H. A. Uydu, M. Bekaroǧlu, and O. Deǧer, “Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments,” Journal of Affective Disorders, vol. 64, no. 1, pp. 43–51, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. S. D. Khanzode, G. N. Dakhale, S. S. Khanzode, A. Saoji, and R. Palasodkar, “Oxidative damage and major depression: the potential antioxidant action of selective serotonin-re-uptake inhibitors,” Redox Report, vol. 8, no. 6, pp. 365–370, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Chen, H. D. Wang, X. Xia, H. F. Kung, Y. Pan, and L. D. Kong, “Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the chronic mild stress model of depression in mice,” Phytomedicine, vol. 14, no. 7-8, pp. 523–529, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. Q. Q. Mao, S. P. Ip, K. M. Ko, S. H. Tsai, Y. F. Xian, and C. T. Che, “Effects of peony glycosides on mice exposed to chronic unpredictable stress: further evidence for antidepressant-like activity,” Journal of Ethnopharmacology, vol. 124, no. 2, pp. 316–320, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Zafir and N. Banu, “Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats,” European Journal of Pharmacology, vol. 572, no. 1, pp. 23–31, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. Zhao, W. Wang, H. Guo, and D. Zhou, “Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats,” Behavioural Brain Research, vol. 194, no. 1, pp. 108–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. W. W. Shang and S. Y. Qiao, “Advances on the study of Danggui Shaoyao powder,” Journal of Chinese Materia Medica, vol. 31, no. 8, pp. 630–633, 2006. View at Google Scholar · View at Scopus
  10. D. Y. Li, “Clinical analysis of Danggui Shaoyao San in treatment of 30 patients with insomnia,” China Journal of Modern Medicine, vol. 20, no. 24, pp. 3787–3789, 2010. View at Google Scholar
  11. W. R. Pigeon, “Insomnia as a predictor of depression: do insomnia subtypes matter?” Sleep, vol. 33, no. 12, pp. 1585–1586, 2010. View at Google Scholar · View at Scopus
  12. J. Kou, D. Zhu, and Y. Yan, “Neuroprotective effects of the aqueous extract of the Chinese medicine Danggui-Shaoyao-san on aged mice,” Journal of Ethnopharmacology, vol. 97, no. 2, pp. 313–318, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. Z. Y. Hu, G. Liu, H. Yuan et al., “Danggui-Shaoyao-San and its active fraction JD-30 improve Aβ-induced spatial recognition deficits in mice,” Journal of Ethnopharmacology, vol. 128, no. 2, pp. 365–372, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Xu, D. Peng, C. Tao et al., “Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of Traditional Chinese Medicine, on depression model in mice and rats,” Phytomedicine, vol. 18, no. 13, pp. 1130–1136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. R. J. Katz, K. A. Roth, and K. Schmaltz, “Amphetamine and tranylcypromine in an animal model of depression: pharmacological specificity of the reversal effect,” Neuroscience and Biobehavioral Reviews, vol. 5, no. 2, pp. 259–264, 1981. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Willner, “Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation,” Psychopharmacology, vol. 134, no. 4, pp. 319–329, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. Mao, Z. Huang, S. Ip, and C. Che, “Antidepressant-like effect of ethanol extract from paeonia lactiflora in mice,” Phytotherapy Research, vol. 22, no. 11, pp. 1496–1499, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Q. Q. Mao, S. P. Ip, K. M. Ko, S. H. Tsai, and C. T. Che, “Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 7, pp. 1211–1216, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Xia, G. Cheng, Y. Pan, Z. H. Xia, and L. D. Kong, “Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test,” Journal of Ethnopharmacology, vol. 110, no. 2, pp. 356–363, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Google Scholar · View at Scopus
  21. J. M. McCord and I. Fridovich, “Superoxide dismutase: the first twenty years (1968–1988),” Free Radical Biology and Medicine, vol. 5, no. 5-6, pp. 363–369, 1988. View at Google Scholar · View at Scopus
  22. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Google Scholar · View at Scopus
  23. J. J. Schildkraut, “The catecholamine hypothesis of affective disorders: a review of supporting evidence,” The American Journal of Psychiatry, vol. 122, no. 5, pp. 509–522, 1965. View at Google Scholar · View at Scopus
  24. N. Bouvier, T. Trenque, and H. Millart, “The development of antidepressants: experience and prospects,” Presse Medicale, vol. 32, no. 11, pp. 519–522, 2003. View at Google Scholar · View at Scopus
  25. M. Bourin, M. Poncelet, R. Chermat, and P. Simon, “The value of the reserpine test in psychopharmacology,” Arzneimittel-Forschung/Drug Research, vol. 33, no. 8, pp. 1173–1176, 1983. View at Google Scholar · View at Scopus
  26. B. Yan, D. Y. Wang, D. M. Xing et al., “The antidepressant effect of ethanol extract of radix puerariae in mice exposed to cerebral ischemia reperfusion,” Pharmacology Biochemistry and Behavior, vol. 78, no. 2, pp. 319–325, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Li, C. Wang, M. Wang, W. Li, K. Matsumoto, and Y. Tang, “Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms,” Life Sciences, vol. 80, no. 15, pp. 1373–1381, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Y. Guo, C. Y. Li, Y. P. Ruan et al., “Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain,” European Journal of Pharmacology, vol. 612, no. 1-3, pp. 54–60, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Y. Guo, H. R. Huo, L. F. Li, S. Y. Guo, and T. L. Jiang, “Sini Tang prevents depression-like behavior in rats exposed to chronic unpredictable stress,” American Journal of Chinese Medicine, vol. 37, no. 2, pp. 261–272, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. L. An, Y. Z. Zhang, N. J. Yu et al., “Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang,” Pharmacology Biochemistry and Behavior, vol. 89, no. 4, pp. 572–580, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Bekris, K. Antoniou, S. Daskas, and Z. Papadopoulou-Daifoti, “Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains,” Behavioural Brain Research, vol. 161, no. 1, pp. 45–59, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Dang, Y. Chen, X. Liu et al., “Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 8, pp. 1417–1424, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Konstandi, E. Johnson, M. A. Lang, M. Malamas, and M. Marselos, “Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats,” Pharmacological Research, vol. 41, no. 3, pp. 341–346, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Sheikh, A. Ahmad, K. B. Siripurapu, V. K. Kuchibhotla, S. Singh, and G. Palit, “Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats,” Journal of Ethnopharmacology, vol. 111, no. 3, pp. 671–676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Itoh, S. Murai, H. Saito, and Y. Masuda, “Effects of single and repeated administrations of Toki-shakuyaku-san on the concentrations of brain neurotransmitters in mice,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 20, no. 1, pp. 11–17, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Lucca, C. M. Comim, S. S. Valvassori et al., “Effects of chronic mild stress on the oxidative parameters in the rat brain,” Neurochemistry International, vol. 54, no. 5-6, pp. 358–362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. I. Niebrój-Dobosz, D. Dziewulska, and H. Kwieciński, “Oxidative damage to proteins in the spinal cord in amyotrophic lateral sclerosis (ALS),” Folia Neuropathologica, vol. 42, no. 3, pp. 151–156, 2004. View at Google Scholar · View at Scopus
  38. X. Xiao, J. Liu, J. Hu et al., “Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca2+ antagonism and antioxidant mechanisms,” European Journal of Pharmacology, vol. 591, no. 1-3, pp. 21–27, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. B. T. Chen, M. V. Avshalumov, and M. E. Rice, “H2O2 is a novel, endogenous modulator of synaptic dopamine release,” Journal of Neurophysiology, vol. 85, no. 6, pp. 2468–2476, 2001. View at Google Scholar · View at Scopus
  40. K. K. Griendling and M. Ushio-Fukai, “Reactive oxygen species as mediators of angiotensin II signaling,” Regulatory Peptides, vol. 91, no. 1-3, pp. 21–27, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. J. M. C. Gutteridge, “Lipid peroxidation and antioxidants as biomarkers of tissue damage,” Clinical Chemistry, vol. 41, no. 12, pp. 1819–1828, 1995. View at Google Scholar · View at Scopus
  42. H. Herken, A. Gurel, S. Selek et al., “Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment,” Archives of Medical Research, vol. 38, no. 2, pp. 247–252, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. T. Posser, M. P. Kaster, S. C. Baraúna, J. B. T. Rocha, A. L. S. Rodrigues, and R. B. Leal, “Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system,” European Journal of Pharmacology, vol. 602, no. 1, pp. 85–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. J. M. Li, L. D. Kong, Y. M. Wang, C. H. K. Cheng, W. Y. Zhang, and W. Z. Tan, “Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction,” Life Sciences, vol. 74, no. 1, pp. 55–73, 2003. View at Publisher · View at Google Scholar · View at Scopus