In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds

Table 2

In vitro effects of the crude extract and fractions against S. mansoni adult worms.

Group	Incubation period (h)	% of dead worms at a given			% reduction in motor activity
		concentration (𝜇g/mL)			at a given concentration (𝜇g/mL)
		50	100	200	50	100	200
ML	24	0	25	n.t.	0	75	n.t.
	120	0	100	n.t.	0	0	n.t.
ML-2	24	0	37.5	n.t.	12.5	0	n.t.
	120	50	62.5	n.t.	37.5	12.5	n.t.
RM	24	0	0	0	0	0	25
	120	0	0	100	0	0	0
RM-1	24	0	0	0	75	75	25
	120	0	100	100	100	0	0
RM-2	24	0	25	n.t.^a	0	75	0
	120	100	100	n.t.	0	0	0
RM-3	24	0	0	0	0	0	0
	120	0	0	0	0	0	0
SS	24	0	0	0	25	100	100
	120	0	0	0	50	100	100
SS-1	24	0	25	25	100	75	75
	120	25	25	25	75	75	50
SS-2	24	0	0	0	0	0	25
	120	0	0	0	0	0	25
SS-3	24	0	0	0	0	0	25
	120	0	0	0	0	25	25
SV	24	0	0	0	0	75	100
	120	0	25	100	100	100	0
SV-1	24	0	0	100	25	50	0
	120	0	100	100	100	0	0
SV-2	24	0	25	100	0	25	0
	120	0	100	100	0	0	0
SV-3	24	0	0	0	0	0	0
	120	0	0	100	0	0	0
Control^b	24	0	0	0	0	0	0
	120	0	0	0	0	0	0
1% DMSO	24	0	0	0	0	0	0
	120	0	0	0	0	0	0

^an.t.: not tested.
^bRPMI 1640.
PZQ at 12.5 𝜇g/mL  = 100% parasite death on 24 h of incubation.