In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds

Table 3

In vitro effects of isolated compounds against S. mansoni adult worms.

Group	Incubation period (h)	% of dead worms at a given			% reduction in motor activity
		concentration (𝜇M)			at a given concentration (𝜇M)
		50	100	200	50	100	200
1	24	0	0	25	0	50	25
	120	0	25	50	0	50	0
2	24	0	0	0	0	0	25
	120	0	0	0	0	0	25
3	24	0	0	0	25	0	50
	120	0	0	0	25	25	50
4	24	0	0	n.t.^a	50	75	n.t.
	120	0	0	n.t.	50	75	n.t.
5	24	0	0	n.t.	0	0	n.t.
	120	0	0	n.t.	0	0	n.t.
6	24	0	0	n.t.	0	25	n.t.
	120	0	0	n.t.	0	0	n.t.
7	24	0	0	n.t.	75	87.5	n.t.
	120	0	25	n.t.	75	87.5	n.t.
Control^b	24	0	0	0	0	0	0
	120	0	0	0	0	0	0
1% DMSO	24	0	0	0	0	0	0
	120	0	0	0	0	0	0

^an.t.: not tested.
^bRPMI 1640.
PZQ at 12.5 𝜇M  = 100% parasite death on 24 h of incubation.