Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 193496, 10 pages
http://dx.doi.org/10.1155/2012/193496
Review Article

Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands

Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and High Altitude Research Institute, Universidad Peruana Cayetano Heredia, Honorio Delgado 430, Lima 31, Peru

Received 24 June 2011; Revised 18 July 2011; Accepted 20 July 2011

Academic Editor: Ulysses Paulino De Albuquerque

Copyright © 2012 Gustavo F. Gonzales. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [62 citations]

The following is the list of published articles that have cited the current article.

  • Yun-Yun Xue, Jie-Si Wang, Lu Zhao, Khalid Rahman, Qiao-Yan Zhang, Lu-Ping Qin, Min Jia, Yan Nie, and Da-Peng Cao, “Potential Antiosteoporotic Agents from Plants: A Comprehensive Review,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, pp. 1–28, 2012. View at Publisher · View at Google Scholar
  • Gustavo F. Gonzales, Manuel Gasco, and Ivan Lozada-Requena, “Role of Maca (Lepidium meyenii) Consumption on Serum Interleukin-6 Levels and Health Status in Populations Living in the Peruvian Central Andes over 4000 m of Altitude,” Plant Foods for Human Nutrition, 2013. View at Publisher · View at Google Scholar
  • David Campos, Rosana Chirinos, Omar Barreto, Giuliana Noratto, and Romina Pedreschi, “Optimized methodology for the simultaneous extraction of glucosinolates, phenolic compounds and antioxidant capacity from maca (Lepidium meyenii),” Industrial Crops and Products, vol. 49, pp. 747–754, 2013. View at Publisher · View at Google Scholar
  • Patricia L. Gerbarg, and Richard P. Brown, “Phytomedicines for Prevention and Treatment of Mental Health Disorders,” Psychiatric Clinics of North America, vol. 36, no. 1, pp. 37–47, 2013. View at Publisher · View at Google Scholar
  • Mohamed F. Elshal, Abdulrahman L. Almalki, K. Hussein Hussein, and Jalal A. Khan, “Synergistic Antiosteoporotic Effect Of Lepidium Sativum And Alendronate In Glucocorticoid-Induced Osteoporosis In Wistar Rats,” African Journal of Traditional Complementary and Alternative Medicines, vol. 10, no. 5, pp. 267–273, 2013. View at Publisher · View at Google Scholar
  • Juana del Valle Mendoza, Tomàs Pumarola, Libertad Alzamora Gonzales, and Luis J. del Valle, “Antiviral activity of maca (Lepidium meyenii) against human influenza virus,” Asian Pacific Journal of Tropical Medicine, vol. 7, pp. S415–S420, 2014. View at Publisher · View at Google Scholar
  • Mark A. Moyad, and Mark A. Moyad, “Complementary and Alternative Medicine for Erectile Dysfunction, Testosterone Replacement Therapy, and Female Sexual Dysfunction,” Complementary & Alternative Medicine for Prostate and Urologic Health, pp. 107–143, 2014. View at Publisher · View at Google Scholar
  • Zsanett Hajdu, Simon Nicolussi, Mark Rau, Laszlo Lorantfy, Peter Forgo, Judit Hohmann, Dezso Csupor, and Juerg Gertsch, “Identification of Endocannabinoid System-Modulating N-Alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii,” Journal of Natural Products, vol. 77, no. 7, pp. 1663–1669, 2014. View at Publisher · View at Google Scholar
  • Zhong Ai, Ai-Fang Cheng, Yuan-Tao Yu, Long-Jiang Yu, and Wenwen Jin, “ Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca ( Lepidium meyenii ) in Mice Exposed to Chronic Unpredictable Mild Stress ,” Journal of Medicinal Food, pp. 140414120257003, 2014. View at Publisher · View at Google Scholar
  • Charles J. Glueck, Caitlin Richardson-Royer, Reiker Schultz, Tim Burger, Dedrick Bowe, Jagjit Padda, and Ping Wang, “Testosterone Therapy, Thrombophilia-Hypofibrinolysis, and Hospitalization for Deep Venous Thrombosis-Pulmonary Embolus: An Exploratory, Hypothesis-Generating Study,” Clinical and Applied Thrombosis-Hemostasis, vol. 20, no. 3, pp. 244–249, 2014. View at Publisher · View at Google Scholar
  • Stephan Henauer, “Maca: Superfood, aphrodisiac, hype?,” Schweizerische Zeitschrift fur GanzheitsMedizin, vol. 26, no. 6, pp. 364–367, 2014. View at Publisher · View at Google Scholar
  • Fumiaki Uchiyama, Tamaki Jikyo, Ryosuke Takeda, and Misato Ogata, “Lepidium meyenii (Maca) enhances the serum levels of luteinising hormone in female rats,” Journal of Ethnopharmacology, vol. 151, no. 2, pp. 897–902, 2014. View at Publisher · View at Google Scholar
  • T. K. Lim, and T. K. Lim, “Lepidium meyenii,” Edible Medicinal and Non Medicinal Plants, pp. 801–828, 2014. View at Publisher · View at Google Scholar
  • Nahid Jivad, and Zahra Rabiei, “A review study on medicinal plants used in the treatment of learning and memory impairments,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 10, pp. 780–789, 2014. View at Publisher · View at Google Scholar
  • Mark A. Moyadpp. 1–265, 2014. View at Publisher · View at Google Scholar
  • Ornella Corazza, Giovanni Martinotti, Rita Santacroce, Eleonora Chillemi, Massimo Di Giannantonio, Fabrizio Schifano, and Selim Cellek, “Sexual Enhancement Products for Sale Online: Raising Awareness of the Psychoactive Effects of Yohimbine, Maca, Horny Goat Weed, and Ginkgo biloba,” BioMed Research International, vol. 2014, pp. 1–13, 2014. View at Publisher · View at Google Scholar
  • Mario Valenzuela-Estrada, Hipólito Núñez, Roberto Parra, Juan P. Velasco-Martín, Javier Regadera, and Eduardo Bustos-Obregón, “Effect of Peruvian maca (Lepidium meyenii) and melatonin on testicular development of mice exposed to continuous hypobaric hypoxia,” International Journal of Morphology, vol. 32, no. 1, pp. 70–78, 2014. View at Publisher · View at Google Scholar
  • Lorántfy, Boros, Hajdu, Jedlinszki, Hohmann, and Csupor, “Quality control of maca-containing (lepidium meyenii walp.) dietary supplements,” Acta Alimentaria, vol. 44, no. 3, pp. 461–467, 2015. View at Publisher · View at Google Scholar
  • Jin-Jin Chen, and Bing Zhao, “Research progress on macamides,” Chinese Traditional and Herbal Drugs, vol. 46, no. 21, pp. 3284–3288, 2015. View at Publisher · View at Google Scholar
  • Hao Liu, Wenwen Jin, Chunhua Fu, Penfei Dai, Yuantao Yu, Qin Huo, and Longjiang Yu, “Discovering anti-osteoporosis constituents of maca (Lepidium meyenii) by combined virtual screening and activity verification,” Food Research International, vol. 77, pp. 215–220, 2015. View at Publisher · View at Google Scholar
  • Ji Zhang, Han-Mo Wang, Yan-Li Zhao, Zhi-Tian Zuo, Yuan-Zhong Wang, and Hang Jin, “ Comparison of Mineral Element Content in a Functional Food Maca ( Lepidium meyenii Walp.) from Asia and South America ,” Journal of Analytical Methods in Chemistry, vol. 2015, pp. 1–4, 2015. View at Publisher · View at Google Scholar
  • Fan Yi, Xiao-lei Tan, Xin Yan, and Hai-bo Liu, “In silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach,” Chinese Medicine, vol. 11, no. 1, 2016. View at Publisher · View at Google Scholar
  • B. M. Dietz, A. Hajirahimkhan, T. L. Dunlap, and J. L. Bolton, “Botanicals and Their Bioactive Phytochemicals for Womens Health,” Pharmacological Reviews, vol. 68, no. 4, pp. 1026–1073, 2016. View at Publisher · View at Google Scholar
  • Jonathan Israel, and Eric L. Laborde, “Alternative and Internet Drugs that Affect Sexual Function,” Contemporary Treatment of Erectile Dysfunction, pp. 137–148, 2016. View at Publisher · View at Google Scholar
  • Yu Pan, Ji Zhang, Hong Li, Yuan-Zhong Wang, and Wan-Yi Li, “Simultaneous Analysis of Macamides in Maca (Lepidium meyenii) with Different Drying Process by Liquid Chromatography Tandem Mass Spectrometry,” Food Analytical Methods, vol. 9, no. 6, pp. 1686–1695, 2016. View at Publisher · View at Google Scholar
  • S. Baldermann, L. Blagojević, K. Frede, R. Klopsch, S. Neugart, A. Neumann, B. Ngwene, J. Norkeweit, D. Schröter, A. Schröter, F. J. Schweigert, M. Wiesner, and M. Schreiner, “Are Neglected Plants the Food for the Future?,” Critical Reviews in Plant Sciences, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  • Yu Pan, Ji Zhang, Hong Li, Yuan-Zhong Wang, and Wan-Yi Li, “ Characteristic fingerprinting based on macamides for discrimination of maca ( Lepidium meyenii ) by LC/MS/MS and multivariate statistical analysis ,” Journal of the Science of Food and Agriculture, vol. 96, no. 13, pp. 4475–4483, 2016. View at Publisher · View at Google Scholar
  • Mark A. Moyadpp. 1–383, 2016. View at Publisher · View at Google Scholar
  • Mark A. Moyad, and Mark A. Moyad, “Rapid Review of Breast Cancer Treatment Side Effects and Dietary Supplement/Integrative Options from A to Z: What Helps, Harms, or Does Nothing?,” Integrative Medicine for Breast Cancer, pp. 225–342, 2016. View at Publisher · View at Google Scholar
  • Xiao-Feng Chen, Yan-Yun Liu, Min-Jie Cao, Ling-Jing Zhang, Le-Chang Sun, Wen-Jin Su, and Guang-Ming Liu, “Hypoxia Tolerance and Fatigue Relief Produced by Lepidium meyenii and its Water-soluble Polysaccharide in Mice,” Food Science and Technology Research, vol. 22, no. 5, pp. 611–621, 2016. View at Publisher · View at Google Scholar
  • Shruti Beharry, and Michael Heinrich, “Is the Hype around the Reproductive Health Claims of Maca( Lepidium meyenii Walp) justified?,” Journal of Ethnopharmacology, 2017. View at Publisher · View at Google Scholar
  • Cindy M. Meston, and Amelia M. Stanton, “Treatment of Female Sexual Interest/Arousal Disorder,” The Textbook of Clinical Sexual Medicine, pp. 165–168, 2017. View at Publisher · View at Google Scholar
  • Kuljeet S. Gugnani, Nguyen Vu, Alejandro N. Rondón-Ortiz, Mark Böhlke, Timothy J. Maher, and Alejandro J. Pino-Figueroa, “Neuroprotective activity of macamides on manganese-induced mitochondrial disruption in U-87 MG glioblastoma cells,” Toxicology and Applied Pharmacology, 2017. View at Publisher · View at Google Scholar
  • A. Y. Onaolapo, B. P. Oladipo, and O. J. Onaolapo, “Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement,” Andrologia, pp. e12911, 2017. View at Publisher · View at Google Scholar
  • Barbara Tenci, Lorenzo Di Cesare Mannelli, Nadia Mulinacci, Carla Ghelardini, Mario Maresca, Laura Micheli, and Giuseppe Pieraccini, “Effects of a water extract of lepidium meyenii root in different models of persistent pain in rats,” Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 72, no. 11-12, pp. 449–457, 2017. View at Publisher · View at Google Scholar
  • Jin-jin Chen, Qing-sheng Zhao, Yi-lan Liu, Peng-fei Gong, Li-li Cao, Xiao-dong Wang, and Bing Zhao, “ Macamides present in the commercial maca ( Lepidium meyenii ) products and the macamide biosynthesis affected by postharvest conditions ,” International Journal of Food Properties, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • Myeong Soo Lee, Tae-Hun Kim, and Hye Won Lee, “The Use of Maca ( Lepidium meyenii ) for Health Care,” Sustained Energy for Enhanced Human Functions and Activity, pp. 167–172, 2017. View at Publisher · View at Google Scholar
  • Kazys Milašius, “Effect of argi+ and multi maca food supplements on sportsmen's physical and functional capacity,” Novosibirsk State Pedagogical University Bulletin, vol. 7, no. 1, pp. 203–215, 2017. View at Publisher · View at Google Scholar
  • Katarzyna Borowska, Agnieszka Wojtowicz, Dorota Kasprzak, and Barbara Jodlowska-Jedrych, “Lepidium meyenii (Maca) – multidirectional health effects – review,” Current Issues in Pharmacy and Medical Sciences, vol. 31, no. 3, pp. 107–112, 2018. View at Publisher · View at Google Scholar
  • Giovanni Martinotti, Emanuela Belfiglio, Rita Santacroce, and Massimo di Giannantonio, “Sexual Dysfunctions and Substance-Related and Addictive Disorders,” Sexual Dysfunctions in Mentally Ill Patients, pp. 153–162, 2018. View at Publisher · View at Google Scholar
  • Qiansi Chen, Meng Li, Chen Wang, Zefeng Li, Jiayang Xu, Qingxia Zheng, Pingping Liu, and Huina Zhou, “Combining Targeted Metabolites Analysis and Transcriptomics to Reveal Chemical Composition Difference and Underlying Transcriptional Regulation in Maca (Lepidium Meyenii Walp.) Ecotypes,” Genes, vol. 9, no. 7, pp. 335, 2018. View at Publisher · View at Google Scholar
  • Serol Korkmaz, “Antioxidants in Maca (Lepidium meyenii) as a Supplement in Nutrition,” Antioxidants in Foods and Its Applications, 2018. View at Publisher · View at Google Scholar
  • Jin-Jin Chen, Peng-Fei Gong, Yi-Lan Liu, Bo-Yan Liu, Dawn Eggert, Yuan-Heng Guo, Ming-Xia Zhao, Qing-Sheng Zhao, and Bing Zhao, “ Postharvest Ultrasound-Assisted Freeze-Thaw Pretreatment Improves the Drying Efficiency, Physicochemical Properties, and Macamide Biosynthesis of Maca ( Lepidium meyenii ) ,” Journal of Food Science, 2018. View at Publisher · View at Google Scholar
  • Lian-ying Liao, Yi-fan He, Li Li, Hong Meng, Yin-mao Dong, Fan Yi, and Pei-gen Xiao, “A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide,” Chinese Medicine, vol. 13, no. 1, 2018. View at Publisher · View at Google Scholar
  • Ines Banjari, Tihana Marček, Svetlana Tomić, and Viduranga Y. Waisundara, “Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies,” Frontiers in Nutrition, vol. 5, 2018. View at Publisher · View at Google Scholar
  • Yue Zheng, Wen-Cheng Zhang, Ze-Yu Wu, Chuan-Xiang Fu, Ai-Ling Hui, Han Gao, Peng-Peng Chen, Biao Du, and Hua-Wei Zhang, “Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice,” Journal of the Science of Food and Agriculture, 2018. View at Publisher · View at Google Scholar
  • Kelly Johnson-Arbor, Kathy Vo, Flavia Wong, and Ryszard Gajek, “Unintentional and Sequential Lead Exposure from a Ceramic Mug and Maca (Lepidium meyenii),” Journal of Medical Toxicology, 2018. View at Publisher · View at Google Scholar
  • C. Del Prete, S. Tafuri, F. Ciani, M. P. Pasolini, F. Ciotola, S. Albarella, D. Carotenuto, V. Peretti, and N. Cocchia, “ Influences of dietary supplementation with Lepidium meyenii (Maca) on stallion sperm production and on preservation of sperm quality during storage at 5 °C ,” Andrology, 2018. View at Publisher · View at Google Scholar
  • Sita Sharan Patel, Ramsaneh Raghuwanshi, Misha Masood, Ashish Acharya, and Surendra Kumar Jain, “Medicinal plants with acetylcholinesterase inhibitory activity,” Reviews in the Neurosciences, no. 0, 2018. View at Publisher · View at Google Scholar
  • Jorge Castro Bedriñana, Doris Chirinos Peinado, and Jorge Calderón Inga, “Nutritional quality of maca stubble (Lepidium peruvianum Chacón) in Guinea pigs,” Revista de Investigaciones Veterinarias del Peru, vol. 29, no. 2, pp. 410–418, 2018. View at Publisher · View at Google Scholar
  • Wenwen Jin, Xuemin Chen, Qing Huo, Yajie Cui, Zejun Yu, and Longjiang Yu, “ Aerial parts of maca ( Lepidium meyenii Walp.) as functional vegetables with gastrointestinal prokinetic efficacy in vivo ,” Food & Function, 2018. View at Publisher · View at Google Scholar
  • David Campos, Rosana Chirinos, Lena Gálvez Ranilla, and Romina Pedreschi, “Bioactive Potential of Andean Fruits, Seeds, and Tubers,” 2018. View at Publisher · View at Google Scholar
  • Paulo R. Ribeiro, and Fernanda V. Carvalho, “Structural diversity, biosynthetic aspects, and LC-HRMS data compilation for the identification of bioactive compounds of Lepidium meyenii,” Food Research International, pp. 108615, 2019. View at Publisher · View at Google Scholar
  • Laura Weiss Roberts, Robert E. Hales, Stuart C. Yudofsky, Lila Massoumi, Patricia Gerbarg, Philip Muskin, and Uma Naidoo, “Complementary and Integrative Psychiatry,” The American Psychiatric Association Publishing Textbook of Psychiatry, 2019. View at Publisher · View at Google Scholar
  • A. Lozano-Canales, M. Janampa-Santome, Daniel Clark, and Wilfredo L. Gonzáles, “Seed weight predicts seedling emergence, and extremely acid soil and low availability of Phosphorus are associated with poor plant performances in Lepidium meyenii Walpers (maca),” Scientia Horticulturae, vol. 253, pp. 341–348, 2019. View at Publisher · View at Google Scholar
  • David L. Rowland, Sean M. McNabney, Krystal R. Mulzon, and Samantha Trammell, “Plant-Derived Supplements for Sexual Health and Problems, Part 2: Further Evidence for Specific Herbal Effects,” Current Sexual Health Reports, 2019. View at Publisher · View at Google Scholar
  • Simona Tafuri, Natascia Cocchia, Domenico Carotenuto, Anastasia Vassetti, Alessia Staropoli, Vincenzo Mastellone, Vincenzo Peretti, Francesca Ciotola, Sara Albarella, Chiara Del Prete, Veronica Palumbo, Luigi Esposito, Francesco Vinale, and Francesca Ciani, “Chemical Analysis of Lepidium meyenii (Maca) and Its Effects on Redox Status and on Reproductive Biology in Stallions †,” Molecules, vol. 24, no. 10, pp. 1981, 2019. View at Publisher · View at Google Scholar
  • Rashmi Saxena Pal, Yogendra Pal, and Pranay Wal, “A Review on Post Pregnancy Healer Herbs,” Current Women s Health Reviews, vol. 15, no. 2, pp. 102–108, 2019. View at Publisher · View at Google Scholar
  • Sunan Wang, and Fan Zhu, “Chemical composition and health effects of maca (Lepidium meyenii),” Food Chemistry, 2019. View at Publisher · View at Google Scholar
  • Ting Wang, Chun-han Sun, Hao-bo Zhong, Yan Gong, Zhong-Kai Cui, Jing Xie, Yan-peng Wang, Chuang Liang, He-he Cao, Xiao-rui Chen, Zhi-peng Zou, Sheng-fa Li, and Xiao-chun Bai, “N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide promotes bone formation via the canonical Wnt/β-catenin signaling pathway,” Phytotherapy Research, 2019. View at Publisher · View at Google Scholar
  • Simona Tafuri, Natascia Cocchia, Anastasia Vassetti, Domenico Carotenuto, Luigi Esposito, Lucianna Maruccio, Luigi Avallone, and Francesca Ciani, “ Lepidium meyenii (Maca) in male reproduction ,” Natural Product Research, pp. 1–10, 2019. View at Publisher · View at Google Scholar
  • Eliza Oprea, Lavinia L. Ruta, and Ileana C. Farcasanu, “Pharmacological Aspects and Health Impact of Sports and Energy Drinks,” Sports and Energy Drinks, pp. 65–129, 2019. View at Publisher · View at Google Scholar