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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 216970, 9 pages
Research Article

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study

1Department of Medicine, Srinivasa Diabetic Research Centre, Bangalore 560 050, India
2Department of Medicine, Cambridge Hospital, Bangalore 560 008, India
3Department of Medicine, Manasa Petal Hospital, Bangalore 560 032, India
4Research and Development Centre, Natural Remedies, Bangalore 560 100, India

Received 25 November 2010; Revised 21 March 2011; Accepted 11 April 2011

Academic Editor: Adair Roberto Soares Santos

Copyright © 2012 Kadur Ramamurthy Raveendra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of GutGard, an extract of Glycyrrhiza glabra, in patients with functional dyspepsia. The primary outcome variables of the study were the change in the severity symptoms and the global assessment of efficacy. The quality of life was evaluated as a secondary outcome measure. The patients received either placebo or GutGard (75 mg twice daily) for 30 days. Efficacy was evaluated in terms of change in the severity of symptoms (as measured by 7-point Likert scale), the global assessment of efficacy, and the assessment of quality of life using the short-form Nepean Dyspepsia Index. In comparison with placebo, GutGard showed a significant decrease () in total symptom scores on day 15 and day 30, respectively. Similarly, GutGard showed marked improvement in the global assessment of efficacy in comparison to the placebo. The GutGard group also showed a significant decrease () in the Nepean dyspepsia index on day 15 and 30, respectively, when compared to placebo. GutGard was generally found to be safe and well-tolerated by all patients. GutGard has shown significant efficacy in the management of functional dyspepsia.