Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 239638, 12 pages
http://dx.doi.org/10.1155/2012/239638
Research Article

JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

1School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
2Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
3Faculty of Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
4China Academy of Chinese Medicine, Beijing, China

Received 27 December 2011; Revised 25 March 2012; Accepted 12 April 2012

Academic Editor: Lixing Lao

Copyright © 2012 Hong-Yan Qin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. P. Dunlop, D. Jenkins, K. R. Neal, and R. C. Spiller, “Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS,” Gastroenterology, vol. 125, no. 6, pp. 1651–1659, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. K. A. Gwee, Y. L. Leong, C. Graham et al., “The role of psychological and biological factors in postinfective gut dysfunction,” Gut, vol. 44, no. 3, pp. 400–406, 1999. View at Google Scholar · View at Scopus
  3. X. Yao, Y. S. Yang, L. H. Cui et al., “Subtypes of irritable bowel syndrome on Rome III criteria: a multicenter study,” Journal of Gastroenterology and Hepatology, vol. 27, no. 4, pp. 760–765, 2012. View at Publisher · View at Google Scholar
  4. R. Spiller and K. Garsed, “Postinfectious irritable bowel syndrome,” Gastroenterology, vol. 136, no. 6, pp. 1979–1988, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. D. D. Price, J. G. Craggs, Q. Zhou, G. N. Verne, W. M. Perlstein, and M. E. Robinson, “Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors: evidence from human psychophysics, animal models, and neuroimaging,” NeuroImage, vol. 47, no. 3, pp. 995–1001, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Stacher and J. Christensen, “Visceral hypersensitivity in irritable bowel syndrome: a summary review,” Digestive Diseases and Sciences, vol. 51, no. 3, pp. 440–445, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Azpiroz, M. Bouin, M. Camilleri et al., “Mechanisms of hypersensitivity in IBS and functional disorders,” Neurogastroenterology and Motility, vol. 19, no. 1, pp. 62–88, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. C. P. Bearcroft, D. Perrett, and M. J. G. Farthing, “Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study,” Gut, vol. 42, no. 1, pp. 42–46, 1998. View at Google Scholar · View at Scopus
  9. A. P. M. Kerckhoffs, J. J. M. Ter Linde, L. M. A. Akkermans, and M. Samsom, “Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients,” Neurogastroenterology and Motility, vol. 20, no. 8, pp. 900–907, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. G. M. Mawe, M. D. Coates, and P. L. Moses, “Review article: intestinal serotonin signalling in irritable bowel syndrome,” Alimentary Pharmacology and Therapeutics, vol. 23, no. 8, pp. 1067–1076, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. L. A. Houghton, W. Atkinson, R. P. Whitaker, P. J. Whorwell, and M. J. Rimmer, “Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome,” Gut, vol. 52, no. 5, pp. 663–670, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. J. H. Park, P. L. Rhee, G. Kim et al., “Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome,” Neurogastroenterology and Motility, vol. 18, no. 7, pp. 539–546, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Greenwood-Van Meerveld, “Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity,” Neurogastroenterology and Motility, vol. 19, no. 2, pp. 13–18, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Thibault, J. Van Steenwinckel, M. J. Brisorgueil et al., “Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat,” Pain, vol. 140, no. 2, pp. 305–322, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. D. Choi, T. S. Sung, H. J. Kim, J. H. La, T. W. Kim, and I. S. Yang, “Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats,” Digestive Diseases and Sciences, vol. 53, no. 11, pp. 2909–2916, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Chen, J. Li, L. Zhang et al., “5-HT3 receptors mediate the time-dependent vagal afferent modulation of nociception during chronic food allergen-sensitized visceral hyperalgesia in rats,” Neurogastroenterology and Motility, vol. 21, no. 11, pp. 1222–e113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Cenac, C. Altier, J. P. Motta et al., “Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity,” Gut, vol. 59, no. 4, pp. 481–488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Ohta, Y. Ikemi, M. Murakami, T. Imagawa, K. I. Otsuguro, and S. Ito, “Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons,” Journal of Physiology, vol. 576, no. 3, pp. 809–822, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Sugiura, K. Bielefeldt, and G. F. Gebhart, “TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation,” Journal of Neuroscience, vol. 24, no. 43, pp. 9521–9530, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Y. Kim and M. Camilleri, “Serotonin: a mediator of the brain-gut connection,” American Journal of Gastroenterology, vol. 95, no. 10, pp. 2704–2709, 2000. View at Google Scholar · View at Scopus
  21. M. D. Gershon and J. Tack, “The serotonin signaling system: from basic understanding to drug development for functional GI disorders,” Gastroenterology, vol. 132, no. 1, pp. 397–414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. P. Bertrand, “Real-time measurement of serotonin release and motility in guinea pig ileum,” Journal of Physiology, vol. 577, no. 2, pp. 689–704, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. M. B. Hansen, “Neurohumoral control of gastrointestinal motility,” Physiological Research, vol. 52, no. 1, pp. 1–30, 2003. View at Google Scholar · View at Scopus
  24. B. A. Moore, K. A. Sharkey, and M. Mantle, “Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine,” American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 270, no. 6, pp. G1001–G1009, 1996. View at Google Scholar · View at Scopus
  25. M. L. Grøndahl, G. M. Jensen, C. G. Nielsen, E. Skadhauge, J. E. Olsen, and M. B. Hansen, “Secretory pathways in Salmonella Typhimurium-induced fluid accumulation in the porcine small intestine,” Journal of Medical Microbiology, vol. 47, no. 2, pp. 151–157, 1998. View at Google Scholar · View at Scopus
  26. S. Kordasti, H. Sjövall, O. Lundgren, and L. Svensson, “Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea,” Gut, vol. 53, no. 7, pp. 952–957, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. R. C. Spiller, D. Jenkins, J. P. Thornley et al., “Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome,” Gut, vol. 47, no. 6, pp. 804–811, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Wang, J. Steeds, Y. Motomura et al., “CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection,” Gut, vol. 56, no. 7, pp. 949–957, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Motomura, J. E. Ghia, H. Wang et al., “Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments,” Gut, vol. 57, no. 4, pp. 475–481, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. D. Coates, C. R. Mahoney, D. R. Linden et al., “Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome,” Gastroenterology, vol. 126, no. 7, pp. 1657–1664, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. M. M. Costedio, N. Hyman, and G. M. Mawe, “Serotonin and its role in colonic function and in gastrointestinal disorders,” Diseases of the Colon and Rectum, vol. 50, no. 3, pp. 376–388, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Spiller, “Serotonin and GI clinical disorders,” Neuropharmacology, vol. 55, no. 6, pp. 1072–1080, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Simrén, J. Axelsson, R. Gillberg, H. Abrahamsson, J. Svedlund, and E. S. Björnsson, “Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors,” American Journal of Gastroenterology, vol. 97, no. 2, pp. 389–396, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Hulisz, “The burden of illness of irritable bowel syndrome: current challenges and hope for the future,” Journal of Managed Care Pharmacy, vol. 10, no. 4, pp. 299–309, 2004. View at Google Scholar · View at Scopus
  35. A. W. Du Pont, “Postinfectious irritable bowel syndrome,” Clinical Infectious Diseases, vol. 46, no. 4, pp. 594–599, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. A. P. S. Hungin, L. Chang, G. R. Locke, E. H. Dennis, and V. Barghout, “Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact,” Alimentary Pharmacology and Therapeutics, vol. 21, no. 11, pp. 1365–1375, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Y. Chang and C. L. Lu, “Treatment of Irritable Bowel Syndrome Using Complementary and Alternative Medicine,” Journal of the Chinese Medical Association, vol. 72, no. 6, pp. 294–300, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. H. A. Shen and R. Nahas, “Complementary and alternative medicine for treatment of irritable bowel syndrome,” Canadian Family Physician, vol. 55, no. 2, pp. 143–148, 2009. View at Google Scholar · View at Scopus
  39. J. J. Y. Sung, Z. X. Bian, J. C. Y. Wu, E. T. Ziea, B. Y. Suen, and W. K. Leung, “Herbal medicine versus hyosine in the treatment of irritable bowelsyndrome: a double-blinded randomized study,” Gut, vol. 56, supplement 3, p. A338, 2007. View at Google Scholar
  40. Z. X. Bian, M. Zhang, Q. B. Han, H. X. Xu, and J. J. Y. Sung, “Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats,” World Journal of Gastroenterology, vol. 16, no. 7, pp. 837–845, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Y. Qin, J. C. Y. Wu, X. D. Tong, J. J. Y. Sung, H. X. Xu, and Z. X. Bian, “Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome,” Journal of Gastroenterology, vol. 46, no. 2, pp. 164–174, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Liebregts, B. Adam, A. Bertel et al., “Effect of E. coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model,” Neurogastroenterology and Motility, vol. 17, no. 3, pp. 410–414, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. E. D. Al-Chaer, “A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development,” Gastroenterology, vol. 119, no. 5, pp. 1276–1285, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Tammpere, M. Brusberg, J. Axenborg, I. Hirsch, H. Larsson, and E. Lindström, “Evaluation of pseudo-affective responses to noxious colorectal distension in rats by manometric recordings,” Pain, vol. 116, no. 3, pp. 220–226, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. Z. Li, X. J. Zhang, H. X. Xu, J. J. Y. Sung, and Z. X. Bian, “Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats,” European Journal of Pharmacology, vol. 606, no. 1–3, pp. 199–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. L. Grimelius, “Silver stains demonstrating neuroendocrine cells,” Biotechnic and Histochemistry, vol. 79, no. 1, pp. 37–44, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. S. D. Qi, S. L. Tian, H. X. Xu, J. J. Y. Sung, and Z. X. Bian, “Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection,” Analytical and Bioanalytical Chemistry, vol. 393, no. 8, pp. 2059–2066, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. P. R. Wade and J. A. Westfall, “Ulstructure of enterochromaffin cells and associated neural and vascular elements in the mouse duodenum,” Cell and Tissue Research, vol. 241, no. 3, pp. 557–563, 1985. View at Google Scholar · View at Scopus
  49. M. Fujimiya, K. Okumiya, and A. Kuwahara, “Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure,” Histochemistry and Cell Biology, vol. 108, no. 2, pp. 105–113, 1997. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Y. Qin, J. L. Luo, S. D. Qi, H. X. Xu, J. J. Y. Sung, and Z. X. Bian, “Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon,” European Journal of Pharmacology, vol. 647, no. 1–3, pp. 75–83, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. P. P. Bertrand and R. L. Bertrand, “Serotonin release and uptake in the gastrointestinal tract,” Autonomic Neuroscience: Basic and Clinical, vol. 153, no. 1-2, pp. 47–57, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Wheatcroft, D. Wakelin, A. Smith, C. R. Mahoney, G. Mawe, and R. Spiller, “Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction,” Neurogastroenterology and Motility, vol. 17, no. 6, pp. 863–870, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. W. Atkinson, S. Lockhart, P. J. Whorwell, B. Keevil, and L. A. Houghton, “Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome,” Gastroenterology, vol. 130, no. 1, pp. 34–43, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. S. P. Dunlop, N. S. Coleman, E. Blackshaw et al., “Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome,” Clinical Gastroenterology and Hepatology, vol. 3, no. 4, pp. 349–357, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. M. Ortiz Lucas, P. Saz Peiró, and J. J. Sebastián Domingo, “Irritable bowel syndrome immune hypothesis. Part two: the role of cytokines,” Revista Espanola de Enfermedades Digestivas, vol. 102, no. 12, pp. 711–717, 2010. View at Google Scholar · View at Scopus
  56. L. Wang, G. B. Zhou, P. Liu et al., “Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 12, pp. 4826–4831, 2008. View at Publisher · View at Google Scholar · View at Scopus