Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 5

Research Article

Protective Role of Phyllanthus niruri Extract against Thioacetamide-Induced Liver Cirrhosis in Rat Model

Table 5

Effects of TAA, PN, and silymarin on hepatic biochemical parameters.

GroupsALT (IU/L)AST (IU/L)ALP (IU/L)T. protein (g/L)Bilirubin (μmol/L)Albumin (g/L)GGT (IU/L)

Control 6 6 . 0 ± 3 . 6 3 1 6 2 . 6 ± 9 . 3 5 1 0 9 . 8 ± 1 0 . 8 5 7 2 . 0 ± 1 . 1 6 2 . 0 ± 0 . 0 0 1 1 . 0 ± 0 . 3 2 8 . 4 ± 0 . 4 0
TAA 1 6 5 . 6 ± 1 9 . 5 8 a 4 8 4 . 8 ± 1 0 3 . 8 3 a 4 3 1 . 2 ± 7 2 . 9 4 a 5 8 . 8 0 ± 1 . 0 7 a 7 . 4 ± 1 . 0 7 a 8 . 4 ± 0 . 2 2 1 8 . 4 ± 3 . 5 a
Silymarin 6 3 . 0 ± 4 . 1 6 c 1 5 8 . 0 ± 1 6 . 7 7 c 8 6 . 0 ± 5 1 . 4 5 6 7 . 2 0 ± 2 . 7 3 c 1 . 8 ± 0 . 3 2 c 1 0 . 8 ± 0 . 7 3 1 3 . 3 ± 0 . 9 7
PN 100 mg/kg 8 2 . 6 ± 4 . 1 0 c 2 8 2 . 2 ± 2 4 . 5 7 c 2 7 2 . 4 ± 1 7 . 3 8 c 7 0 . 0 ± 1 . 0 0 b 5 . 2 ± 0 . 9 2 1 0 . 4 ± 0 . 3 8 1 5 . 6 ± 2 . 2 5
PN 200 mg/kg 7 8 . 2 ± 6 . 3 9 c 1 8 0 . 6 ± 2 5 . 8 6 c 1 4 0 . 2 ± 2 6 . 6 3 c 7 1 . 2 5 ± 0 . 6 6 c 3 . 4 ± 0 . 3 7 c 1 0 . 7 ± 0 . 1 5 1 1 . 0 ± 1 . 7 6

All values are expressed as mean ± S.E.M. Means with different superscripts are significantly different. a 𝑃 < 0 . 0 5 versus normal control group, b 𝑃 < 0 . 0 5 versus TAA control group, and c 𝑃 < 0 . 0 1 versus TAA control group. ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, GGT: gamma glutamyl transferase.

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