Protective Role of Phyllanthus niruri Extract against Thioacetamide-Induced Liver Cirrhosis in Rat Model

Table 5

Effects of TAA, PN, and silymarin on hepatic biochemical parameters.

Groups	ALT (IU/L)	AST (IU/L)	ALP (IU/L)	T. protein (g/L)	Bilirubin (μmol/L)	Albumin (g/L)	GGT (IU/L)
Control	66.0±3.63	162.6±9.35	109.8±10.85	72.0±1.16	2.0±0.00	11.0±0.32	8.4±0.40
TAA	165.6±19.58^a	484.8±103.83^a	431.2±72.94^a	58.80±1.07^a	7.4±1.07^a	8.4±0.22	18.4±3.5^a
Silymarin	63.0±4.16^c	158.0±16.77^c	86.0±51.45	67.20±2.73^c	1.8±0.32^c	10.8±0.73	13.3±0.97
PN 100 mg/kg	82.6±4.10^c	282.2±24.57^c	272.4±17.38^c	70.0±1.00^b	5.2±0.92	10.4±0.38	15.6±2.25
PN 200 mg/kg	78.2±6.39^c	180.6±25.86^c	140.2±26.63^c	71.25±0.66^c	3.4±0.37^c	10.7±0.15	11.0±1.76

All values are expressed as mean ± S.E.M. Means with different superscripts are significantly different. ^a𝑃<0.05 versus normal control group, ^b𝑃<0.05 versus TAA control group, and ^c𝑃<0.01 versus TAA control group. ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, GGT: gamma glutamyl transferase.