Inhibition of NO₂, PGE₂, TNF-𝜶, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity

Table 4

Effect of extracts on carrageenan- and dextran-induced paw edema.

Treatment	Dose (mg/kg)	Carrageenan induced paw edema	% Inhibition	Dextran induced paw edema	% Inhibition
Control	0.1 mL	2.1±0.05	—	2.86±0.01	—
Diclofenac disodium	10	0.51±0.005	75.71	0.68±0.014	76.22
Aqueous extract	200	0.97±0.006	53.80	1.18±0.010	58.74
	400	0.73±0.008	65.23	0.88±0.010	69.23
Methanol extract	200	1.08±0.007	48.57	1.36±0.011	52.44
	400	0.80±0.009	61.90	1.07±0.013	62.58

Results are expressed as mean ± SEM (𝑛=6). The significance level in comparison to control values, 𝑃<0.001. Control aqueous Tween-80 solution (2% v/v).