Evaluation of the Chinese Medicinal Herb, Graptopetalum paraguayense, as a Therapeutic Treatment for Liver Damage in Rat Models
Table 1
Summary of rat model histopathological scores.
Factor (scores)
DMN
DMN + GP
DMN + Silymarin
GP
Control
1-2 wk
3-4 wk
5-6 wk
2 wk
3-4 wk
5-6 wk
2 wk
3-4 wk
5-6 wk
2–6 wk
1–6 wk
n (%)
n (%)
n (%)
n (%)
n (%)
n (%)
n(%)
n (%)
n (%)
n (%)
n (%)
Necroinflammatory
A0
0 (0)
1 (9)
4 (44)
3 (50)
4 (45)
9 (64)
0 (0)
2 (22)
2 (20)
10 (100)
100 (24)
A (1–3)
5 (62.5)
3 (27)
4 (44)
3 (50)
2 (22)
1 (7)
3 (75)
3 (33)
2 (20)
0 (0)
0 (0)
A (4–6)
3 (36.5)
7 (64)
1 (12)
0 (0)
3 (33)
4 (29)
1 (25)
4 (45)
6 (60)
0 (0)
0 (0)
Fibrosis
F (0-1)
6 (75)
1 (9)
2 (22)
6 (100)
8 (67)
7 (50)
3 (75)
3 (33)
0 (0)
10 (100)
100 (24)
F (2-3)
2 (25)
10 (91)
7 (78)
0 (0)
4 (33)
7 (50)
1 (25)
6 (67)
10 (100)
0 (0)
0 (0)
Fatty change
−
7 (87.5)
11 (100)
9 (100)
6 (100)
12 (100)
14 (100)
4 (100)
8 (89)
10 (100)
10 (100)
100 (24)
+
1 (12.5)
0 (0)
0 (0)
0 (0)
0 (0)
0 (0)
0 (0)
1 (11)
0 (0)
0 (0)
0 (0)
Results are ranked by time course. Necroinflammatory change was scored as A (0), no change; A (1–3), mild; A (4–6), moderate necroinflammation. Fibrosis was graded as F (0-1) for observations ranging from normal tissue to fibrous expansion of portal tracts and F (2-3) for bridge fibrosis to frequent bridging fibrosis with nodule formation. The fatty change was classified by its presence or absence (+/−). The number of rats was counted and used to calculate the percentage of each histopathological level at each time point. n: number of rats.
