Dose-Dependent Effects of the Cimicifuga racemosa Extract Ze 450 in the Treatment of Climacteric Complaints: A Randomized, Placebo-Controlled Study
Table 2
Intention to treat analysis: total KMI after 12 weeks of treatment ().
Treatment
n
Baseline
End of study
Absolute differences
Hierarchical test procedure*
Mean (SD)
95% CI
Mean (SD)
95% CI
Mean (SD)
95% CI
Step 1
Step 2
Step 3
Placebo
54
27.30 (6.5)
25.53–29.06
28.94 (7.6)
26.87–31.02
1.65 (9.0)
−0.80–4.10
Reference
Reference
Low dose
57
28.12 (6.9)
26.28–29.96
19.65 (13.1)
16.17–23.13
−8.47 (11.0)
−11.39 to −5.55
Reference
High dose
55
28.44 (8.0)
26.28–30.60
11.44 (9.1)
8.98–13.90
−17.00 (8.7)
−19.35 to −14.65
*According to two-sided Mann-Whitney test stratified to individual baseline scores; 95% CI: 95% confidence interval; SD: standard deviation; n: number of patients.
