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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 263520, 9 pages
Research Article

Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

1Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2Integrative Complementary Alternative Medicine Research Group, Khon Kaen University, Khon Kaen 40002, Thailand
3Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
4The Queen Sirikit Department of Sericulture, Ministry of Agriculture and Cooperatives, Bangkok 10900, Thailand

Received 18 June 2012; Accepted 27 June 2012

Academic Editor: Yukihiro Shoyama

Copyright © 2012 Pratchaya Kaewkaen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nowadays, the preventive strategy of vascular dementia, one of the challenge problems of elderly, has received attention due to the limitation of therapeutic efficacy. In this study, we aimed to determine the protective effect and possible mechanism of action of mulberry fruit extract on memory impairment and brain damage in animal model of vascular dementia. Male Wistar rats, weighing 300–350?g, were orally given mulberry extract at doses of 2, 10 and 50?mg/kg at a period of 7 days before and 21 days after the occlusion of right middle cerebral artery (Rt.MCAO). It was found that rats subjected to mulberry fruits plus Rt.MCAO showed the enhanced memory, the increased densities of neuron, cholinergic neuron, Bcl-2-immunopositive neuron together with the decreased oxidative stress in hippocampus. Taken all data together, the cognitive enhancing effect of mulberry fruit extract observed in this study might be partly associated with the increased cholinergic function and its neuroprotective effect in turn occurs partly via the decreased oxidative stress and apoptosis. Therefore, mulberry fruit is the potential natural cognitive enhancer and neuroprotectant. However, further researches are essential to elucidate the possible active ingredient.