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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 270752, 7 pages
http://dx.doi.org/10.1155/2012/270752
Research Article

Effect of a Semisolid Formulation of Linum usitatissimum L. (Linseed) Oil on the Repair of Skin Wounds

1Department of Physiology and Pharmacology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
2Department of Histology and Embryology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
3Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
4Laboratory of Pharmacology of Bioactive Products, Department of Physiology and Pharmacology, Federal University of Pernambuco, Avenida Professor Moraes Rêgo, S/N, Cidade Universitária, 50670-901 Recife, PE, Brazil

Received 3 February 2011; Revised 13 April 2011; Accepted 20 April 2011

Academic Editor: Ronald Sherman

Copyright © 2012 Eryvelton de Souza Franco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to investigate the effects of a semisolid formulation of linseed oil, SSFLO (1%, 5%, or 10%) or in natura linseed oil on skin wounds of rats. We used wound models, incisional and excisional, to evaluate, respectively, the contraction/reepithelialization of the wound and resistance to mechanical traction. The groups ( ) treated with SSFLO (1% or 5%) began the process of reepithelialization, to a significant extent ( ), on the sixth day, when compared to the petroleum jelly control group. On 14th day for the groups treated with SSFLO (1% or 5%), 100% reepithelialization was found, while in the petroleum jelly control group, this was only 33.33%. Our study showed that topical administration of SSFLO (1% or 5%) in excisional wounds allowed reepithelialization in 100% of treated animals. Therefore, a therapeutic potential of linseed oil, when used at low concentrations in the solid pharmaceutical formulations, is suggested for the process of dermal repair.