Evidence-Based Complementary and Alternative Medicine

Evidence-Based Complementary and Alternative Medicine / 2012 / Article
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Medical Ethnobiology and Ethnopharmacology in Latin America

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Research Article | Open Access

Volume 2012 |Article ID 272749 | https://doi.org/10.1155/2012/272749

Isanete Geraldini Costa Bieski, Fabrício Rios Santos, Rafael Melo de Oliveira, Mariano Martinez Espinosa, Miramy Macedo, Ulysses Paulino Albuquerque, Domingos Tabajara de Oliveira Martins, "Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)", Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 272749, 36 pages, 2012. https://doi.org/10.1155/2012/272749

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Academic Editor: Maria Franco Trindade Medeiros
Received16 Aug 2011
Accepted03 Oct 2011
Published26 Feb 2012


Traditional knowledge is an important source of obtaining new phytotherapeutic agents. Ethnobotanical survey of medicinal plants was conducted in Nossa Senhora Aparecida do Chumbo District (NSACD), located in Poconé, Mato Grosso, Brazil using semi-structured questionnaires and interviews. 376 species of medicinal plants belonging to 285 genera and 102 families were cited. Fabaceae (10.2%), Asteraceae (7.82%) and Lamaceae (4.89%) families are of greater importance. Species with the greater relative importance were Himatanthus obovatus (1.87), Hibiscus sabdariffa (1.87), Solidago microglossa (1.80), Strychnos pseudoquina (1.73) and Dorstenia brasiliensis, Scoparia dulcis L., and Luehea divaricata (1.50). The informant consensus factor (ICF) ranged from 0.13 to 0.78 encompassing 18 disease categories,of which 15 had ICF greater than 0.50, with a predominance of disease categories related to injuries, poisoning and certain other consequences of external causes (ICF  =  0.78) having 65 species cited while 20 species were cited for mental and behavioral disorders (ICF  =  0.77). The results show that knowledge about medicinal plants is evenly distributed among the population of NSACD. This population possesses medicinal plants for most disease categories, with the highest concordance for prenatal, mental/behavioral and respiratory problems.

1. Introduction

Despite the fact that modern medicine, on the basis of the complex pharmaceutical industry, is well developed in most part of the world, the World Health Organization (WHO) through it Traditional Medicine Program recommends its Member States to formulate and develop policies for the use of complementary and alternative medicine (CAM) in their national health care programmes [1]. Among the components of CAM, phytotherapy practiced by the greater percentage of the world population through the use of plants or their derivatives, occupies a significant and unique position [2].

In this sense, documentation of the indigenous knowledge through ethnobotanical studies is important in the conservation and utilization of biological resources [3].

Brazil is a country with floral megadiversity, possessing six ecological domains, namely, Amazonian forest, Caatinga, Pampas, Cerrado, Atlantic Forest, and the Pantanal [4]. Mato Grosso region is noteworthy in this regard, as it occupies a prominent position both in the national and international settings, for it presents three major Brazilian ecosystems (the Pantanal, Cerrado, and Amazonian rainforest). Besides this, it also hosts diverse traditional communities in its territories, namely, the Indians descents (Amerindians), African descents, and the white Europeans. However, due to the mass migration from the rural areas and technological development, coupled with globalization of knowledge by the dominant nations, cultural tradition concerning the use of medicinal plants is in the major phase of declining [5].

The Pantanal is distinguishably the largest wetland ecosystem of the world, according to the classification by UNESCO World Heritage Center (Biosphere Reserve) [4]. The Pantanal vegetation is a mosaic consisting of species of the Amazonian rainforest, Cerrado, Atlantic forest, and Bolivian Chaco, adapted to special conditions, where there is alternations of both high humidity and pronounced dryness during the time of the year [4]. The presence in the Pantanal of the traditional populations that use medicinal plants for basic health care makes this region an important field for the ethnobotanical and ethnopharmacological studies [6, 7].

Because of the fact that the Pantanal communities are relatively isolated, they have developed private lives that involved much reliance on profound knowledge of the biological cycles, utilization of natural resources, and traditional technology heritage [8].

As a result of the aforementioned, this study aimed to systematically and quantitatively evaluate the information gathered from these Pantanal communities, highlight the relevance of the ethnobotanical findings, and cite and discuss relevant literatures related to medicinal plants with greater relative importance (RI) and high informant consensus factor (ICF) values obtained in the study.

2. Materials and Methods

2.1. Study Area

For the choice of study area, literature search was conducted to identify the Pantanal region in Mato Grosso, consisting of traditional communities where such studies have not yet been conducted and/or there were no ethnobotanical survey publications. The study design was cross-sectional and was conducted between the period of November, 2009 and February, 2010. The study setting chosen was NSACD located in the Poconé municipality, Mato Grosso State, Central West of Brazil (Figure 1) with coordinates of 16° 02′ 90′′ S and 056° 43′ 49′′ W. Poconé is located within the region of Cuiabá River valley, with an altitude of 142 m, occupies a territorial area of 17,260.86 km2, and of tropical climate. The mean annual temperature is 24°C (4–42°C) and the mean annual rainfall is 1,500 mm with rainy season occurring between December and February. The municipality is composed of 2 Districts (NSAC and Cangas), 5 villages, 11 settlements, 14 streets, and 72 communities (countryside) [9]. The population of NSACD is estimated to be 3,652 inhabitants, representing 11.5% of Poconé municipality [10]. The principal economic activities are mainly livestock farming, mining, and agriculture with great tourism potentials, because Poconé municipality is the gateway to the Pantanal region [9].

2.2. Consent and Ethical Approval

Authorization and ethical clearance were sought from the relevant government (Health authority of Poconé and the National Council of Genetic Heritage of the Ministry of Environment (CGEN/MMA), Resolution 247 published in the Federal Official Gazette, in October, 2009, on access to the traditional knowledge for scientific research and Federal University of Mato Grosso and Júlio Muller Hospital Research Ethical Committees, Protocol 561/CEP-HUJM/08 authorities. Previsits were made to each community of NSACD to present the research project as well as to seek the consent of each potential informant.

2.3. Data Collection and Analysis

In this present study, sampling was done using probabilistic simple randomization and stratified sampling techniques [10, 11].

The population studied consists of inhabitants of 13 communities of NSACD, Mato Grosso State, considering an informant per family. The criteria for each informant chosen were age of 40 and above, residing in NSACD for more than 5 years (because there is large migration into the area because of the presence of ethanol producing factory).

These criteria are in line with the study objective coupled with the information gathered from the local authority [12].

In order to determine the estimated sample size (𝑛), in this case, the number of families to be sampled per communities being considered, the following formula was utilized [11, 13]:𝑛=𝑁𝑝(1𝑝)(𝑁1)𝑑/𝑧𝛼/22+𝑝(1𝑝).(1)

This study considered the population size of 1,179 families (𝑁=1, 179), confidence coefficient of 95% (𝑧/2=1.96), sampling error of 0.05 (𝑑=0.05), a proportion of 0.5 (𝑃=0.5). It should be noted that the 𝑃=0.5 was assigned due to nonexistence of previous information about this value as is usual in practice, to obtain conservative sample size which is representative at the same time.

In determining the sample size for the microarea, 5% error and 10% loss in sample were considered. To determine the sample size in each microarea, the sample size (290) was multiplied by the sampling fraction of each microarea and dividing the total number of families of the same microarea with the total number of families of all the microareas (1,179), thereby arriving at the sample sizes for each area as shown in Table 1.

ID COMMUNITYTotal number of individualsTotal number of familiesSample fractionSample size

2Canto do Agostinho, Santa Helena, Os Cagados, Várzea bonita179520.044115
3Furnas II, Salobra, Zé Alves165590.050015
4Campina II, Furnas I, Mundo Novo, Rodeio279810.068720
5Campina de Pedra, Imbé188670.056816
6Barreirinho, Coetinho, Figueira253950.080623
7Bahia de Campo257740.062818
8Agrovila, São Benedito184660.056016
9Agroana372178 0. 151044
10Bandeira, Minadouro248820.069620
11Carretão, Deus Ajuda, Sangradouro, Pesqueiro, Varzearia216770.065319
12Chafariz, Ramos, Sete Porcos, Urubamba208670.056816
13Céu Azul, Capão Verde, Morro Cortado, Passagem de Carro, Varal157650.055116


ID = identification of the microarea.

The interviews were conducted with the help of 12 trained applicators, under the supervision of the respective investigator. Data collected included sociodemographic details, vernacular names of the plant species with their medicinal uses, methods of drug preparation, and other relevant information. The ethnobotanical data were organized using the Microsoft Office Access 2003 program and statistically analyzed using SPSS, version 15 for Windows (SPSS Inc., Chicago, Illinois, USA).

2.4. Plant Collection, Identification, and Herborization

The collection of plant materials were done in collaboration with the local specialists, soon after the interviews. Both indigenous and scientific plant names were compiled. The plant materials collected during the study period were herborized, mounted as herbarium voucher specimens, and deposited for taxonomic identification and inclusion in the collection of Federal University of Mato Grosso and CGMS Herbarium of Federal University of Mato Grosso do Sul, Brazil.

Plant species were identified according to standard taxonomic methods, based on floral morphological characters, analytical keys, and using, where possible, samples for comparison, as well as consultations with experts and literature [6, 7, 1419]. The plant species obtained were grouped into families according to the classification system of Cronquist [20], with the exception of the Pteridophyta and Gymnospermae. For corrections of scientific names and families, the official website of the Missouri Botanical Garden was consulted [21].

2.5. Quantitative Ethnobotany

The relative importance (RI) of each plant species cited by the informants was calculated according to a previously proposed method [22]. In order to calculate RI, the maximum obtainable by a species is two was calculated using (2) according to Oliveira et al. [23]RI=NCS+NP,(2) where RI: relative importance; NCS: number of body systems. It is given by the number of body systems, treated by a species (NSCS) over the total number of body system treated by the most versatile species (NSCSV): NCS = NSCS/NSCSV; NP: number of properties attributed to a specific species (NPS) over the total number of properties attributed to the most versatile species (NPSV): NP = NPS/NPSV.

We sought to identify the therapeutic indications which were more important in the interviews to determine the informant consensus factor (ICF), which indicates the homogenity of the information [23].

The ICF will be low (close to 0), if the plants are chosen randomly, or if the informants do not exchange information about their uses. The value will be high (close to 1), if there is a well defined criterion of selection in the community and/or if the information is exchanged among the informants [23].

ICF was calculated using the number of use citations in each category of plant disease (𝑛ur), minus the number of species used (𝑛𝑡) divided by the number of use citations in each category minus one on the basis of (3):𝑛ICF=ur𝑛𝑡𝑛ur1.(3)

The citations for therapeutic purposes were classified using the 20 categories of the International Classification of Diseases and Related Health Problems, 10th edition-CID [24]: injuries, certain infectious, and parasitic diseases (I); neoplasms-tumors (II), diseases of blood and blood-forming organs and certain disorders involving the immune mechanism (III), endocrine, nutritional and metabolic diseases (IV) mental and behavioral disorders (V), nervous system (VI), diseases of eye and adnexa (VII), diseases of the ear and mastoid process (VIII), diseases of the circulatory system (IX), respiratory diseases (X), digestive diseases (XI), diseases of the skin and subcutaneous tissue (XII), diseases of the musculoskeletal system and connective tissue (XIII), genitourinary diseases (XIV), pregnancy, childbirth and (XV), certain conditions originating during the perinatal period (XVI), symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (XVIII) and injury, poisoning and certain other consequences of external causes (XIX).

We selected for further discussion species that presented RI ≥ 1.5, and are in a category with high ICF. We conducted literature review using among others, the databases of Web of Science, MEDLINE, SciELO and including nonindexed works. We also searched national data bases for dissertations and theses.

3. Results

A total of 262 informants were interviewed, representing 7.17% of the population of NSACD, 22.22% of the population aged ≥40 years and residing in the District for over five years. Of the respondents, 69% were female and 31% male, aged 40–94 years (median 55). 68% were born in the city of Poconé, and 62% have been residents for over 20 years in the District (Table 2).

IDComunityPopulationNumber of individualsaSample fractionSample sizeNPlant citations

1Chumbo 9462160.18325250 827
2Canto do Agostinho, Santa Helena, Os Cagados, Várzea bonita 179 520.04411510 131
3Furnas II, Salobra, Zé Alves165590.050151099
4Campina II, Furnas I, Mundo Novo, Rodeio279810.06872011179
5Campina de Pedra, Imbé188670.05681612173
6Barreirinho, Coetinho, Figueira253950.08062323213
7Bahia de Campo257740.06281813461
8Agrovila, São Benedito184660.0561616141
10Bandeira, Minadouro248820.06962022171
11Carretão, Deus Ajuda, Sangradouro, Pesqueiro, Varzearia216770.06531923180
12Chafariz, Ramos, Sete Porcos, Urubamba208670.05681616200
13Céu Azul, Capão Verde, Morro Cortado, Passagem de Carro, Varal157650.05511618165

ID: Identification of the microarea; N: Sample size; aInformants with age ≥ 40 years and period of residing ≥ 5 years.

Of the 262 respondents, 259 (99.0%) reported the use of medicinal plants in self health care, with a minimum of 1 plant and a maximum of 250 plants among the female respondents and a minimum of 2 plants and a maximum of 54 among the male respondents. A total of 3,289 citations were recorded corresponding to 376 different plant species which belong to 285 genera and 102 families. Fabaceae (10.2%), Asteraceae (7.82%), and Lamaceae (4.89%) families were the most representative in this study (Table 3).

Family/speciesVernacular nameApplicationPreparation (administration)Uses listedNCSNP RI

 1.1. Justicia pectoralis Jacq.Anadorpain, fever, laxative, and muscle relaxantInfusion (I)36230.40
 2.1. Sambucus australis Cham. & Schltdl.SabugueiroFever and measlesInfusion (I, E)24220.33
 3.1. Echinodorus macrophyllus (Kuntze.) MicheliChapéu-de- couroblood cleanser, stomach, rheumatism, and kidneys 43 4 4 0.67
 4.1. Allium cepa L.Cebolawound healingInfusion (I)1110.17
 4.2. Allium fistulosum L.CebolinhaFluInfusion (I)1110.17
 4.3. Allium sativum L.AlhohypertensionInfusion (I)7110.17
 5.1. Alternanthera brasiliana (L.) KuntzeTerramicinawound healing, itching, diabetes, pain, bone fractures, throat, flu, inflammation uterine, and relaxative muscularInfusion (I, E) 41 6 9 1.20
 5.2. Alternanthera dentata(Moench) Stuchlik ex R.E. Fr.Ampicilinawound healing and kidneysInfusion (I, E)7220.33
 5.3. Alternanthera ficoide (L.) P. Beauv.Dorilmuscular relaxativeInfusion (I, E)3110.17
 5.4. Amaranthus aff. viridis L.Caruru-de-porcowound healing, pain, and kidneysInfusion (I)4330.50
 5.5. Beta vulgaris L.BeterrabaanemiaInfusion (I)1110.17
 5.6. Celosia argentea L.Crista-de-galokidneys 5 3 3 0.50
 5.7. Chenopodium ambrosioides L.Erva-de-santa-mariawound healing, heart, diabetes, bone fractures, flu, kidneys, cough, and wormsInfusion (I, E) 102 7 8 1.23
 5.8. Pfaffia glomerata (Spreng.) PedersenGinseng-brasileiroObesityInfusion (I) 2 1 1 0.17
 6.1. Anacardium humile A. St.– Hil.Cajuzinho-do-campodiabetes, dysentery, and hepatitisInfusion (I, E)5330.50
 6.2. Anacardium occidentale L.Cajueiroabortive, wound healing, cholesterol, teeth, blood cleanser, diabetes, diarrhea, dysentery, and painInfusion (I, E) 30 6 9 1.20
 6.3. Astronium fraxinifolium Schott ex SprengGonçaleiroflu, hemorrhoids, and coughInfusion and maceration (I, E)8330.50
 6.4. Mangifera indica L.MangueiraBronchitis, flu, and coughInfusion and maceration (I, E)11230.40
 6.5. Myracrodruon urundeuva (Allemão) Engl.Aroeiraanemia, bladder bronchitis cancer, wound healing, blood cleanser, bone fractures, hernia, uterine inflammation, muscular relaxative, and coughInfusion, maceration, and decoction (I, E) 84 7 11 1.43
 6.6. Spondias dulcis ParkinsonCaja-mangascabiesInfusion (I, E)2110.17
 6.7. Spondias purpurea L.Seriguelawound healing and hepatitisInfusion (I, E)2220.33
 7.1. Annona cordifolia Poepp. ex Maas & WestraAraticum-abelhaDiabetes and bone fracturesInfusion and decoction (I, E)3220.33
 7.2. Annona crassiflora Mart.GravioladiabetesInfusion (I, E)11110.17
 7.3. Duguetia furfuracea (A. St.- Hil.) Saff.Beladona-do-cerradopainInfusion (I, E)1110.17
 8.1. Coriandrum sativum L.CoentrofluInfusion (I)1110.17
 8.2. Eryngium aff. pristis Cham. & Schltdl.Lingua-de-tucanoTooth and muscular relaxativeInfusion (I)3220.33
 8.3. Petroselinum crispum ((Mill) FussSalsinhafluInfusion (I)1110.17
 8.4. Pimpinella anisum L.Erva-docepain soothing, constipation, and kidneysInfusion (I, E)12 3 3 0.50
 9.1. Aspidosperma polyneuron (Müll.) Arg.PérobaStomach and laxativeInfusion and decoction (I, E)5 1 2 0.23
 9.2. Aspidosperma tomentosum Mart.GuatambugastritisInfusion (I)4110.17
 9.3. Catharanthus roseus (L.) G. DonBoa-noitemumps fever and kidneysInfusion (I)8330.50
 9.4. Geissospermum laeve (Vell.) MiersPau-tenenteDiabetes and painInfusion (I)6220.33
 9.5. Hancornia speciosa var. gardneri (A. DC.) Müll. Arg.Mangava-mansaitching, diarrhea, and stomachDecoction and maceration (I, E)8 3 3 0.50
 9.6. Himatanthus obovatus (Müll. Arg.) WoodsonAngélicaanemia, wound healing, cholesterol, blood cleanser, pain, nose bleeding, hypertension, uterine inflammation, labyrinthitis, pneumonia, relaxative muscular, worms, and vitiligoMaceration (I) 45 10 13 1.87
 9.7. Macrosiphonia longiflora (Desf.) Müll. Arg.Velame-do-campohearth, blood cleanser, stroke, diuretic, pain, throat, muscular relaxative, and vitiligoDecoction (I) 5 6 81.13
 9.8. Macrosiphonia velame (A. St.-Hil.) Müll. Arg.Velame-brancofluDecoction (I)73110.17
 10.1 Dieffenbachia picta SchottComigo-ninguém-podepainMaceration (E)2110.17
 10.2. Dracontium sp.JararaquinhasnakebiteInfusion (I)10110.17
 11.1. Acrocomia aculeata Lodd. ex. Mart.Bocaiuveiraheart, hepatitis, hypertension, and kidneysDecoction and syrup (I)20 4 4 0.67
 11.2. Cocos nucifera L.Cocô-da-bahiakidneysMaceration (I)2110.17
 11.3. Orbignya phalerata Mart.BabaçuinflammationDecoction (I)8110.17
 11.4. Syagrus oleracea (Mart.) Becc.GuarirobakidneysMaceration (I)2110.17
 12.1. Aristolochia cymbifera Mart & Zucc.Cipó-de-mil-homemdengue, blood cleanser, stomach, kidneys, and digestiveInfusion (I)11 4 5 0.73
 12.2. Aristolochia esperanzae KuntzePapo-de-peruwound healingInfusion (I)3110.17
 13.1. Acanthospermum australe (Loefl.). KuntzeCarrapicho, beijo-de-boicolic, kidneys, and runny coughInfusion (I)31230.40
 13.2. Acanthospermum hispidum DC.Chifre-de-garrotinhoGonorrhea and kidneysInfusion (I)5230.40
 13.3. Achillea millefolium L.Dipirona, Novalgina,pain, flu, and muscular relaxativeInfusion (I)13340.57
 13.4. Achyrocline satureioides (Lam.) DC.Macela-do-campodiarrhea, pain, stomach, gastritis, flu, and hypertensionInfusion (I)13560.90
 13.5. Ageratum conyzoides L.Mentrastopain, labor pain, stomach, swelling in pregnant woman, rheumatism, and coughInfusion (I)18 5 6 0.90
 13.6. Artemisia vulgaris L.ArtemisiainsomniaInfusion (I)3110.17
 13.7. Artemisia absinthium L.Losna, nor-vômicapain, stomach, liver, hernia, and muscular relaxativeInfusion (I)39 4 5 0.73
 13.8. Baccharis trimera (Less.) DC.Carquejacancer, cholesterol, diabetes, diuretic, stomach, flu, and obesityInfusion (I)31 5 7 0.97
 13.9. Bidens pilosa L.Picão-pretohepatitis, enteric, and kidneysInfusion (I, E)20 3 30.50
 13.10. Brickellia brasiliensis (Spreng.) B.L. Rob.Arnica-do-campowound healing, uterine inflammation, and kidneysInfusion (I)13 2 3 0.40
 13.11. Calendula officinalis L.CalêndulaanxietyInfusion (I)6110.17
 13.12. Centratherum aff. punctatum Cass.Perpétua-roxamuscular relaxative, and hearthInfusion (I)3220.33
 13.13. Chamomilla recutita (L.) Rauschert.Camomilasoothing colic, pain, stomach, fever, and fluInfusion (I)78 5 6 0.90
 13.14. Chaptalia integerrima (Vell.) BurkartLingua-de-vacawormsInfusion (I)6110.17
 13.15. Chromolaena odorata (L.) R.M. King & H. RobCruzeirinhocolic, pain, bone fractures, pain, bone fractures, and kidneysInfusion (I)7 3 4 0.57
 13.16. Conyza bonariensis (L.) CronquistVoadeiracancer itching, blood cleanser, leukemia, and wormsInfusion (I)15 4 5 0.73
 13.17. Elephantopus mollis KunthSussuaiáblood cleanser, pain, and uterine inflammationInfusion (I)11 2 3 0.40
 13.18. Emilia fosbergii NicolsonSerralhaconjunctivitisInfusion (I)6110.17
 13.19. Eremanthus exsuccus (DC.) BakerBácimo-do-campowound healing, stomach, bone fractures, and skinInfusion and maceration (I, E)11 3 4 0.57
 13.20. Eupatorium odoratum L.Arnicãowound healing, muscular relaxative, and kidneysInfusion (I, E)10 3 3 0.50
 13.21. Mikania glomerata Spreng.Guacobronchitis coughInfusion (I)14220.33
 13.22. Mikania hirsutissima DC.Cipó-cabeludodiabetesInfusion (I)10110.17
 13.23. Pectis jangadensis S. MooreErva-do-carregadorblood cleanser and diabetesInfusion (I)4 2 2 0.33
 13.24. Porophyllum ruderale (Jacq.) Cass.Picão-brancoHepatitis and kidneysInfusion (I) 11 2 2 0.33
 13.25. Solidago microglossa DC.Arnica-brasileirawound healing, blood cleanser, pain, bone fractures, hypertension, uterine inflammation, muscular relaxative, kidneys, worms, pain, stomach, hypertension, pneumonia, constipation, and relaxative muscularInfusion (I, E)82 8 15 1.80
 13.26. Spilanthes acmella (L.) MurrayJambúliverInfusion (I)5110.17
 13.27. Tagetes minuta L.Cravo-de-defuntoDengue and fluInfusion (I)3220.33
 13.28. Taraxacum officinale L.Dente-de-leãoblood cleanserInfusion (I)18110.17
 13.29. Tithonia diversifolia (Hemsl.) A. GrayFlor-da-amazôniaalcoholism, stomach, kidney, and constipationInfusion (I)16330.50
 13.30.Vernonia condensata BakerFigatil-caferanacancer stomach and liverInfusion (I)48230.40
 13.31. Vernonia scabra Pers.Assa-peixebronchitis blood cleanser, fever, flu, pneumonia, cold, and coughInfusion and syrup (I)38 270.67
 13.32. Zinnia elegans Jacq.JacintapainInfusion (I)1110.17
 14.1. Berberis laurina Billb.Raiz-de-são-joãoblood cleanser and diarrheaDecoction and bottle (I, E)6220.33
 15.1. Anemopaegma arvense (Vell.) Stellfeld & J.F. SouzaVerga-teso, Alecrim-do-campo, Catuabaanxiety soothing kidneysDecoction and bottle (I, E)13230.40
 15.2. Arrabidaea chica (Humb. & Bonpl.) B. Verl.Crajirúwound healing and blood cleanserInfusion (I)6220.33
 15.3. Cybistax antisyphilitica (Mart.) Mart.Pé-de-antafever, flu, relaxative muscular, and wormsInfusion (I)13440.67
 15.4. Jacaranda caroba (Vell.) A. DC.Carobawound healingDecoction and bottle (I, E)3110.17
 15.5. Jacaranda decurrens Cham.Carobinhaallergy cancer wound healing, blood cleanser, diabetes, leprosy, hemorragia no nariz, inflammation uterina, and kidneysDecoction and bottle (I, E)94 8 9 1.40
 15.6. Tabebuia aurea (Silva Manso) B. & H. f. ex S. MooreIpê-amarelowormsDecoction and bottle (I)2110.17
 15.7. Tabebuia caraiba (Mart.) BureauPara-tudoprostate cancer anemia, bronchitis cancer blood cleanser, diarrhea, pain, stomach, cough, and wormsDecoction and bottle (I, E)67 6 10 1.27
 15.8. Tabebuia impetiginosa (Mart. ex DC.) Standl.Ipê-roxoprostate cancer coughDecoction and bottle (I)8220.33
 15.9. Tabebuia serratifolia NicholsonPiúvaprostate cancerDecoction and bottle (I, E)3110.17
 15.10. Zeyhera digitalis (Vell.) Hochn.Bolsa-de-pastorStomachDecoction and bottle (I)9110.17
 16.1. Bixa orellana L.Urucumcholesterol, stroke, bone fractures, and measlesInfusion (I)11 4 4 0.67
 16.2. Cochlospermum regium (Schrank) Pilg.Algodãozinho-do-campoblood cleanser, stomach, bone fractures, inflammation uterina, syphilis, vitiligo, gonorrhea, and ringwormInfusion (I)37 6 9 1.20
 17.1. Pseudobombax longiflorum (Mart. Et Zucc.) Rob.Embiriçu-do-cerradopneumonia, cough, and tuberculosisInfusion (I)17330.50
 17.2. Eriotheca candolleana (K. Schum.)Catuabaprostate cancer1110.17
 18.1. Cordia insignis Cham.Calção-de-velhocoughInfusion (I)5110.17
 18.2. Heliotropium filiforme Lehm.Sete-sangriathooth, blood cleanser, hypertension, and tuberculosisInfusion (I)43440.67
 18.3. Symphytum asperrimum Donn ex SimsConfreiwound healing, heart, throat, and obesityInfusion (I, E)10440.67
 19.1. Nasturtium officinale R. Br.AgriãobronchitisInfusion (I)2110.17
 20.1. Ananas comosus (L.) Merr.Abacaxidiuretic and coughInfusion (I)9220.33
 20.2. Bromelia balansae MezGravatácough and bronhitisInfusion (I)2220.33
 21.1. Commiphora myrrha (T. Nees) Engl.MirraMenstruation and rheumatismInfusion (I)3220.33
 21.2. Protium heptaphyllum (Aubl.) MarchandAlmésicablood cleanser, stroke, pain, muscular relaxative, rheumatism, and cough23 3 60.70
 22.1. Cactus alatus Sw.CactoColic and guard deliveryInfusion (I, E)10220.33
 22.2. Opuntia sp.Palmacolumn2110.17
 22.3. Pereskia aculeata Mill.Oro-pro-nobisanemiaInfusion (I)2110.17
 23.1. Crataeva tapia L.CabaçacoughInfusion (I)2110.17
 23.2. Cleome affinis DC. Mussambédiarrhea1110.17
 24.1. Carica papaya L.Mamoeiroworms, thooth, stomach, hepatitis, muscular relaxative, and coughInfusion (I)17 4 6 0.80
 25.1. Caryocar brasiliense A. St.-Hil.Pequizeirodiabetes, hypertension, labyrinthitis, and obesity11 4 4 0.67
 26.1. Maytenus ilicifolia Mart.ex ReissekEspinheira-santauric acid, bronchitis diarrhea, stomach, gastritis, flu, and coughInfusion (I)8 5 7 0.97
 27.1. Cecropia pachystachya TréculEmbaúbacholesterol, blood cleanser, diabetes, pain, hypertension, leukemia, pneumonia, kidneys, and coughInfusion (I)38 6 91.20
 28.1. Kielmeyera aff. grandiflora (Wawra) SaddiPau-santoanemia1110.17
 29.1. Terminalia argentea Mart.Pau-de-bichoitching, diabetes, and cough8330.50
 29.2. Terminalia catappa L.Sete-copaconjunctivitisInfusion (I, E)2110.17
 30.1. Commelina benghalensis L.CapoerabahemorrhoidsInfusion (I)1110.17
 30.2. Commelina nudiflora L.Erva-de-santa-luziawound healing and conjunctivitisInfusion (I)3220.33
 30.3. Dichorisandra hexandra (Aubl.) Standl.Cana-de-macacoflu, hypertension, and kidneysInfusion (I)1330.50
 31.1. Cuscuta racemosa Mart.Cipó-de-chumbopainInfusion (I)1110.17
 31.2. Ipomoea batatas (L.) Lam.Batata-docehearthInfusion (I)1110.17
 31.3. Ipomoea (Desr.) Roem. & asarifolia SchultBatatinha-do-brejoStomach and wormsInfusion (I)4220.33
 32.1. Costus spicatus (Jacq.) Sw.Caninha-do-brejobladder diuretic, inflammation uterina, muscular relaxative, and kidneysInfusion (I)40 3 5 0.63
 33.1. Kalanchoe pinnata (Lam.) Pers.Folha-da-fortunaallergy, bronchitis blood cleanser, and fluInfusion and juice (I)11240.47
 34.1. Cayaponia tayuya (Cell.) Cogn.Raiz-de-bugreblood cleanser, pain, and hepatitisInfusion (I)17230.40
 34.2. Citrullus vulgaris Schrad.Melânciabladder colicInfusion (I)2120.23
 34.3. Cucumis anguria L.MáxixeanemiaInfusion (I)1110.17
 34.4. Cucumis sativus L.PepinohypertensionMaceration (I)1
 34.5. Cucurbita maxima Duchesne ex Lam.AbóboraPain and wormsInfusion (I)4220.33
 34.6. Luffa spBuchaAnemia and kidneysInfusion (I)7220.33
 34.7. Momordica charantia L.Melão-de-são-caetanobronchitis dengue, stomach, fever, flu, hepatitis, swelling in pregnant woman, malaria, muscular relaxative, and wormsInfusion (I)506101.27
 34.8. Siolmatra brasiliensis (Cogn.) Baill.TaiuáUlcerInfusion (I)6110.17
 35.1. Bulbostylis capillaris (L.) C.B. ClarkeBarba-de-bodediuretic, stomach, kidneys, and wormsInfusion (I)12340.57
 35.2. Cyperus rotundus L.TiriricaPainInfusion (I)1110.17
 36.1. Curatella americana L.Lixeirawound healing, colic, diarrhea, flu, kidneys, and coughInfusion (I, E)24560.90
 36.2. Davilla elliptica A. St.-Hil.Lixeira-de-cipókidneys3110.17
 36.3. Davilla nitida (Vahl.) KubitzkiLixeirinhadelivery help, liver, hernia, and kidneysInfusion (I)10340.57
 37.1. Dioscorea sp.Cará-do-cerradoboilInfusion (I)25110.17
 37.2. Dioscorea trifida LCaráblood cleanserInfusion (I)6110.17
 38.1. Diospyros hispida A. DC.Olho-de-boiPain and leprosyInfusion (I)5220.33
 39.1. Equisetum arvense L.Cavalinhagastritis and kidneysInfusion (I)8220.33
 40.1 Erythroxylum aff. Daphnites Mart.Vasoura-de-bruxasyphilisInfusion (I)1110.17
 41.1. Croton antisyphiliticus Mart.CurraleiraHypertension and uterine inflammationInfusion (I)6220.33
 41.2. Croton sp.Curraleira-brancauterine inflammationInfusion (I)3110.17
 41.3. Croton urucurana Baill.Sangra-d’águacancer prostate cancer healing, diabetes, stomach, gastritis, uterine inflammation, kidneys, and ulcerMaceration (I)37 5 9 1.10
 41.4. Euphorbia aff. Thymifolia L.Trinca-pedrakidneysInfusion (I)3110.17
 41.5. Euphorbia prostrata AitonFura-pedrakidneysInfusion (I)4110.17
 41.6. Euphorbia tirucalli LAvelozcancer uterine inflammationMaceration (I)3220.33
 41.7. Jatropha sp.Capa-rosadiabetesInfusion (I)10110.17
 41.8. Jatropha elliptica (Poh) OkenPurga-de-lagartoallergyInfusion (I)38110.17
 41.9. Jatropha aff. Gossypiifolia L.Pinhão-roxowound healing, prostrate cancer, itching, blood cleanser, stroke, snakebite, syphilis, worms, and vitiligoMaceration(I, E)7 6 10 1.27
 41.10. Jatropha urens L.CansansãodiabetesMaceration (I, E)6110.17
 41.11. Manihot esculenta CrantzMandioca-brabaitchingMaceration (I, E)2110.17
 41.12. Manihot utilissima Pohl.MandiocaitchingMaceration (I, E)7110.17
 41.13. Ricinus communis L.Mamonawound healing and blood cleanserMaceration (I, E)8220.33
 41.14. Synadenium grantii Hook. f.Cancerosagastritis, prostate cancer stomach, and pneumoniaMaceration (I, E)12 3 40.57
 42.1. Acosmium dasycarpum (Volgel) YakovlevCinco-folhacolumn, blood cleanser, pain, and kidneysInfusion (I)19 240.47
 42.2. Acosmium subelegans (Mohlenbr.) YakovlevQuina-gensianawound healing, blood cleanser, pain, liver, uterine inflammation, delivery relapse, and kidneysDecoction (I)16 5 7 0.97
 42.3. Albizia niopoides (Spr. ex Benth.) Burkart.Angico-brancobronhitisDecoction (I)1110.17
 42.4. Amburana cearensis (Allemão) A. C. Sm.ImburanacoughDecoction (I)13110.17
 42.5. Anadenanthera colubrina (Vell.) BrenanAngicoasthma, wound healing, expectorant, uterine inflammation, pneumonia, and coughDecoction (I)12 5 6 0.90
 42.6. Andira anthelminthica Benth.AngelimdiabetesDecoction (I)3110.17
 42.7. Bauhinia variegata L.Unha-de-boikidneysDecoction (I)4110.17
 42.8. Bauhinia ungulata L.Pata-de-vacadiabetesInfusion (I)11110.17
 42.9. Bauhinia glabra Jacq.Cipó-tripa-de-galinhadiarrhea, dysentery, and painInfusion (I)7330.50
 42.10. Bauhinia rubiginosa Bong.Tripa-de-galinhakidneysInfusion (I)2110.17
 42.11. Bauhinia rufa (Bong.) Steud.Pata-de-boidiabetesInfusion (I)1110.17
 42.12. Bowdichia virgilioides KunthSucupirablood cleanser, paom, stomach, nose bleeding, cough, and wormsBottle (I)20 4 6 0.80
 42.13. Caesalpinia ferrea Mart.Jucáwound healing, stomach, bone fractures, and inflammation of uterineMaceration (I, E)15 3 4 0.57
 42.14. Cajanus bicolor DC.Feijão-andudiarrhea, stomach and wormsInfusion (I)8230.40
 42.15. Cassia desvauxii Collad.Seneconstipation, pain, fever, uterine inflammation, and labyrinthitisInfusion (I)18 4 5 0.73
 42.16. Chamaecrista desvauxii (Collad.) KillipSene-do-campoconstipation, blood cleanser, pain, and feverInfusion (I)10 2 4 0.47
 42.17. Copaifera sp.Pau-d’óleowound healing, kidneys, ulcerInfusion (I)8330.50
 42.18. Copaifera langsdorffii var. glabra (Vogel) Benth.Copaibabronchitis prostate cancer stroke, pain, throat, and tuberculosisMaceration and syrup (I)13 5 6 0.90
 42.19. Copaifera marginata Benth.GuaranazinhoulcerInfusion (I)4110.17
 42.20. Desmodium incanum DC.Carrapichobladder itching, diarrhea, pain, hepatitis, and kidneysInfusion (I)18560.90
 42.21. Dimorphandra mollis Benth.Fava-de-santo-ináciobronchitis wound healing, pain, flu, hypertension, pneumonia, rheumatism, cough, and wormsInfusion (I)21 6 91.20
 42.22. Dioclea latifolia Benth.Fruta-olho-de-boistrokeInfusion (I)3110.17
 42.23. Dioclea violacea Mart. Zucc.Coronha-de-boiosteoporosisInfusion (I)6220.33
 42.24. Dipteryx alata VogelCumbarúbronchitis cicartrizante, diarrhea, dysentery, pain, throat, flu, snakebite, and coughInfusion (I)43 4 9 1.00
 42.25. Galactia glaucescens KunthTrês-folhascolumn, pain, bone fractures, and kidneysInfusion (I)8440.67
 42.26. Hymenaea courbaril L.Jatobá-mirimbladder bronchitis flu, pneumonia, and coughSyrup and decoction (I)36350.63
 42.27. Hymenaea stigonocarpa Mart. ex HayneJatoba-do-cerradobronchitis prostate cancer pain, fertilizer, flu, and coughSyrup and decoction (I)31 5 6 0.90
 42.28. Indigofera suffruticosa Mill.AnilulcerInfusion (I)2110.17
 42.29. Inga vera Willd.IngáLaxative and kidneysInfusion (I)5220.33
 42.30. Machaerium hirtum (Vell.) StellfeldEspinheira-santa-nativaulcerInfusion (I)2110.17
 42.31. Melilotus officinalis (L) Pall.Trevo-cheirosobone fractures and thyroidInfusion (I)5220.33
 42.32. Mimosa debilis var. vestita (Benth.) BarnebyDorme-dormesoothingInfusion (I)2110.17
 42.33. Mucuna pruriens (L.) DC.MacunastrokeInfusion (I)2110.17
 42.34. Peltophorum dubium (Spreng.) Taub.Cana-fistulagastritisInfusion (I)5110.17
 42.35. Platycyamus regnellii Benth.Pau-porreteanemiaInfusion (I)1110.17
 42.36. Pterodon pubescens (Benth.) Benth.Sucupira-brancaworms, pain, and stomachSYRope, decoction and maceration (I)2 3 3 0.50
 42.37. Senna alata (L.) Roxb.Mata-pastothroat, worms, and vitiligoInfusion (I)6330.50
 42.38. Senna occidentalis (L.) LinkFedegosoblood cleanser, pain, flu, cough, and wormsInfusion (I)42 3 5 0.63
 42.39. Stryphnodendron obovatum Benth.Barbatimão 1wound healingSyrup and decoction (I, E) 57 1 1 0.17
 42.40. Stryphnodendron adstringens (Mart.) CovilleBarbatimão 2bladder bronchitis, colic, stomach, bone fractures, uterine inflammation, relaxative muscular, and ulcerSyrup and decoction (I, E)15 4 9 1.00
 42.41. Tamarindus indica L.Tamarindoanxiety pain, thooth, laxative, osteoporosis, syphilis, and wormsMaceration and juice (I)30 6 7 1.07
 43.1. Casearia silvestris Sw.GuaçatongaEpilepsy and kidneysInfusion (I)3220.33
 44.1. Ginkgo biloba L.Ginco-bilobavertebralInfusion (I)1110.17
 45.1. Herreria salsaparilha Mart.Salsaparilhacolumn, blood cleanser, muscular relaxative, and kidneysInfusion (I)12 3 4 0.57
 46.1. Salacia aff. elliptica (Mart. ex Schult.) G. DonSaputa-do-brejopainInfusion (I)6110.17
 47.1. Eleutherine bulbosa (Mill.) Urb.Palmeirinhapain, hemorrhoids, cough, and blood cleanserInfusion (I)11240.47
 48.1. Hyptis cf. hirsuta KunthHortelã-do-campodiabetes, stomach, flu, cough, and wormsInfusion (I)23550.83
 48.2. Hyptis paludosa St.-Hil.ex Benht.AlevantecoldInfusion (I)4110.17
 48.3. Hyptis sp.Hortelã-bravoDiabetes and coughInfusion (I)6220.33
 48.4. Hyptis suaveolens (L.) Poit.Tapera-velhapain, stomach, flu, constipation, kidneys, and wormsInfusion (I)42 5 6 0.90
 48.5. Leonotis nepetifolia (L.) R. Br.Cordão-de-são-franciscocolumn, hearth, blood cleanser, stomach, fever, gastritis, flu, hypertension, labyrinthitis, muscular relaxative, and kidneysInfusion (I)38 7 11 1.43
 48.6. Marsypianthes chamaedrys (Vahl) KuntzeAlfavaca/Hortelã-do-matoflu, hypertension, and coughInfusion (I)8330.50
 48.7. Melissa officinalis LMelissasoothingInfusion (I)2110.17
 48.8. Mentha crispa L.Hortelã-folha-miudaanemia, liver, cough, and wormsInfusion (I)16440.67
 48.9. Mentha pulegium L.Poejobronchitis soothing fever, flu, cold, and coughInfusion (I)59360.70
 48.10. Mentha spicata L.Hortelã-vickibronchitis flu, wound healing, stomach, and wormsInfusion (I)24450.73
 48.11. Mentha x piperita L.Hortelã-pimentabronchitis flu, cough and wormsInfusion (I)42340.57
 48.12. Mentha x villosa Huds.Hortelã-rasteirastomach, flu, cold, and wormsInfusion (I)86340.57
 48.13. Ocimum kilimandscharicum Baker ex GürkeAlfavacaquinhafluInfusion (I)2110.17
 48.14. Ocimum minimum L.Manjericãokidneys, sinusitis, and wormsInfusion (I)7330.50
 48.15. Origanum majorana L.ManjeronaheartInfusion (I)4110.17
 48.16. Origanum vulgare L.OréganocoughInfusion (I)1110.17
 48.17. Plectranthus amboinicus (Lour.) Spreng.Hortelã-da-folha-gordabronchitis flu, uterine inflammation, and coughInfusion and syrup (I)7 3 4 0.57
 48.18. Plectranthus barbatus AndrewsBoldo-brasileiropain, stomach, liver, and malaiseMaceration (I)99 2 40.47
 48.19. Plectranthus neochilus Schltr.BoldinhostomachMaceration (I)1110.17
 48.20. Rosmarinus officinalis L.Alecrimanxiety soothing hearth, pain, hypertension, insomnia, labyrinthitis, sluggishness memory, tachycardia, and vitiligoInfusion and maceration (I)31 6 10 1.27
 49.1. Cinnamomum camphora (L.) Nees & Eberm.CânforapainInfusion and maceration (I)1110.17
 49.2. Cinnamomum zeylanicum BreyneCanela-da-indiaaphrodisiac, tonic, obesity, and coughInfusion (I)11340.57
 49.3. Persea americana Mill.Abacateirodiuretic, hypertension, and kidneysInfusion and maceration (I)31330.50
 50.1. Cariniana rubra Gardner ex MiersJequitibábladder wound healing, colic, pain, uterine inflammation, rheumatism, cough, and ulcerInfusion and maceration (I)49 5 8 1.03
 51.1. Strychnos pseudoquina A. St.-Hil.Quinaanemia, wound healing, cholesterol, blood cleanser, pain, stomach, bone fractures, flu, uterine inflammation, pneumonia, muscle relaxant, cough, ulcer, and wormsDecoction and maceration (I, E)107 8 14 1.73
 52.1. Psittacanthus calyculatus (D.C.) G. DonErva-de-passarinhostroke, pain, flu, and pneumoniaInfusion and maceration (I)14340.57
 53.1. Adenaria floribunda KunthVeludo-vermelhokidneys3110.17
 53.2. Lafoensia pacari A. St.-Hil.Mangava-brabawound healing, diarrhea, pain, stomach, gastritis, kidneys, and ulcerDecoction and maceration (I, E)73 5 7 0.97
 54.1. Byrsonima orbignyana A. Juss.Angiquinhowound healingDecoction and maceration (I)2110.17
 54.2. Byrsonima sp.SemaneirapainInfusion (I)1110.17
 54.3. Byrsonima verbascifolia (L.) DC.Murici-do-cerradocolumnInfusion (I)3220.33
uterine inflammation
 54.4. Camarea ericoides A. St.-Hil.Arniquinhawound healingInfusion (I)11110.17
 54.5. Galphimia brasiliensis (L.) A. Juss.Mercúrio-do-campowound healing, itching, thooth, and bone fracturesInfusion (I)7 3 4 0.57
 54.6. Heteropterys aphrodisiaca O. Mach.Nó-de-cachorrobrain, wound healing, blood cleanser, impotence, muscular relaxative, and rheumatismDecoction (I)23 5 6 0.90
 54.7. Malpighia emarginata DC.Cerejawound healingInfusion (I)5110.17
 54.8. Malpighia glabra L.Aceroleirabronchitis dengue, stomach, fever, and fluInfusion (I)24 4 50.73
 55.1. Brosimum gaudichaudii TréculMama-cadelastomachInfusion (I)13110.17
 55.2. Gossypium barbadense L.Algodão-de-quintalblood cleanser, stomach, vitiligo, inflammation, and gonorrheaInfusion (I)47 5 5 0.83
 55.3. Guazuma ulmifolia var. tomentosa (Kunth) K. Schum.Chico-magrodiarrhea, kidneys, bronchitis wound healingInfusion and decoction (I)10 4 4 0.67
 55.4. Hibiscus pernambucensis Bertol.Algodão-do-brejowound healing, colic, flu, and uterine inflammationInfusion (I)2340.57
 55.5. Hibiscus rosa-sinensis L.PrimaverapainInfusion (I)2110.17
 55.6. Hibiscus sabdariffa L.Quiabo-de-angola, Hibiscoanxiety hearth, flu, tachycardia, kidneys, colic, runny, diarrhea, pain, uterine inflammation, labyrinthitis, snakebite, and pneumoniaInfusion (I)18 10 13 1.87
 55.7. Helicteres sacarolha A. St.-Hil.Semente-de-macacoHypertension and ulcerInfusion (I)2220.33
 55.8. Malva sylvestris L.Malva-brancawound healing, conjunctivitis, runny, blood cleanser, diuretic, boil, uterine inflammation, and rheumatismInfusion (I)31 7 8 1.23
 55.9. Malvastrum corchorifolium (Desr.) Britton ex SmallMalvatonsillitis wound healing, pain, and uterine inflammationInfusion (I)13 4 4 0.67
 55.10. Sida rhombifolia L.GuaxumaobesityInfusion (I)5110.17
 56.1. Leandra purpurascens (DC.) Cogn.PixiricarheumatismInfusion (I)1110.17
 56.2. Tibouchina clavata (Pers.) WurdackCibalenapainInfusion (I)3110.17
 56.3. Tibouchina urvilleana (DC.) Cogn.Buscopam-de-casastomachInfusion (I)1110.17
 57.1. Azadirachta indica A. Juss.NeemdiabetesInfusion and decoction (I, E)1110.17
 57.2. Cedrela odorata L.Cedrowound healingInfusion (I)3110.17
 58.1. Cissampelos sp.Orelha-de-onçaColumn and kidneysInfusion (I)3220.33
 59.1. Artocarpus integrifolia L.f.JacadiureticInfusion (I)1110.17
 59.2. Chlorophora tinctoria (L.) Gaudich. ex Benth.Taiúvaosteoporosis and muscular relaxativeInfusion (I)2 2 2 0.33
 59.3. Dorstenia brasiliensis Lam.Carapiáwound healing, colic, thooth, blood cleanser, dysentery, pain, flu, laxative, menstruation, pneumonia, relapse delivery, and kidneysInfusion (I)41 7 12 0.50
 59.4. Ficus brasiliensis Link.FigogastritisInfusion (I)4110.17
 59.5. Ficus pertusa L. f.FigueirinhastomachInfusion (I)5110.17
 60.1. Musa x paradisiaca L.Bananeira-de-umbigobronchitis anemia and painInfusion and syrup (I)9330.50
 61.1. Eucalyptus citriodora Hook.Eucáliptobronchitis diabetes, fever, flu, sinusitis, and coughInfusion and syrup (I)22360.70
 61.2. Eugenia pitanga (O. Berg) Kiaersk.Pitangapain, throat, flu, and kidneysInfusion (I)10340.57
 61.3. Psidium guajava L.GoiabeiradiarrheaInfusion (I)19110.17
 61.4. Psidium guineense Sw.Goiaba-áraçapain, diarrhea, and hypertensionInfusion (I)11330.50
 61.5. Syzygium aromaticum (L.) Merr. & L. M. PerryCravo-da-indiaThroat and coughInfusion (I)5120.23
 61.6. Syzygium jambolanum (Lam.) DC.Azeitona-pretacholesterolDecoction (I, E)4110.17
 62.1. Boerhavia coccinea L.Amarra-pintobladder icterus, inflammation uterina, and kidneysInfusion (I)22240.47
 62.2. Mirabilis jalapa L.Maravilhaheart, pain, and hypertensionInfusion (I)8230.40
 63.1. Ximenia americana L.Limão-bravoTrush and diureticInfusion (I)4220.33
 64.1. Agonandra brasiliensis Miers ex Benth. & Hook f.Pau-marfimuterine inflammationDecoction (I, E)1110.17
 65.1. Vanilla palmarum (Salzm. ex Lindl.) Lindl.BaunilhahypertensionInfusion (I)2110.17
 65.2. Oncidium cebolleta (Jacq.) Sw.OrquideapainInfusion (I)2110.17
 66.1. Averrhoa carambola L.CarambolahypertensionInfusion (I)8110.17
 66.2. Oxalis aff. hirsutissima Mart. ex Zucc.AzedinhaobesityInfusion (I)9110.17
 67.1. Argemone mexicana L.Cardo-santohypertensionInfusion (I)8110.17
 68.1. Passiflora alata CurtisMaracujáInfusion (I)9110.17
 68.2. Passiflora cincinnata Mast.Maracujá-do-matosoothing hypertensionInfusion (I)5220.33
 69.1 Sesamum indicum L.Gergelimstomach, liver, gastritis, ulcer, and wormsInfusion and maceration (I)12250.53
 70.1. Phyllanthus niruri L.Quebra-pedrakidneysInfusion (I)32110.17
 71.1. Petiveria alliacea L.GuinérheumatismInfusion (I, E)4110.17
 72.1. Piper callosum Ruiz & PavVentre-livre/elixir paregóricokidneysInfusion (I)1110.17
 72.2. Piper cuyabanum C. DC.Jaborandipain, stomach, and loss of hairInfusion (I, E)10330.50
 72.3. Pothomorphe umbellata (L.) Miq.Pariparobablood cleanser, stomach, liver, and pneumoniaInfusion (I)11330.50
 73.1. Plantago major L.Tanchagemheart, pain, and laxativeInfusion (I)16330.50
 74.1. Andropogon bicornis L.Capim-rabo-de-lobouterine inflammationInfusion (I)3110.17
 74.2. Coix lacryma-jobi L.Lácrimas-de-nossa-senhorakidneysInfusion (I, E)4110.17
 74.3. Cymbopogon citratus (DC.) StapfcCapim-cidreirasoothing blood cleanser, pain, stomach, expectorant, fever, flu, hypertension, muscular relaxative, kidneys, tachycardia, and coughInfusion and juice (I)49 5 12 1.30
 74.4. Cymbopogon nardus (L.) Rendle.Capim-citronelaflu, cough, and tuberculosisInfusion (E)11220.33
74.5. Digitaria insularis (L.) Mez ex EkmanCapim-amargosowound healing, stomach, bone fractures, and rheumatismInfusion (I)14340.57
74.6. Eleusine indica (L.) Gaertn.Capim-pé-de-galinhaHypertension and swelling in pregnant womanInfusion (I)6220.33
 74.7. Imperata brasiliensis Trin.Capim-sapédiabetes, pain, hepatitis, kidneys, and vitiligoInfusion (I)12550.83
 74.8. Melinis minutiflora P. Beauv.Capim-gorduradengue, blood cleanser, stroke, flu, kidneys, sinusitis, cough, and tumorsInfusion (I)31 7 8 1.23
 74.9. Oryza sativa L.ArrozbladderInfusion (I)1110.17
 74.10. Saccharum officinarum L.Cana-de-açúcarkidneys, anemia, and hypertensionInfusion (I)2330.50
 74.11. Zea mays L.Milhobladder kidneysInfusion (I)3220.33
 75.1. Polygala paniculata L.BenguérheumatismInfusion (I)6110.17
 76.1. Coccoloba cujabensis Wedd.UveiradiureticInfusion (I)1110.17
 76.2. Polygonum cf. punctatum ElliottErva-de-bichowound healing, dengue, stomach, fever, flu, and hemorrhoidsInfusion (I)41 5 6 0.90
 76.3. Rheum palmatum L.Ruibarboblood cleanser, dysentery, pain, and snakebiteInfusion (I)6440.67
 76.4. Triplaris brasiliana Cham.NovaterodiabetesInfusion (I)1110.17
 77.1. Phlebodium decumanum (Willd.) J. Sm.Rabo-de-macacodiuretic, hepatitis, and kidneysInfusion (I)9230.40
 77.2. Pteridium aquilinum (L.) KuhnSamambaiacolic, blood cleanser, and rheumatismInfusion (I)8330.50
 77.3. Pteridium sp.Samambaia-de-ciporheumatismInfusion (I)1110.17
78.1. Eichhornia azurea (Sw.) KunthAguapéulcerInfusion (I)3110.17
 79.1. Portulaca oleracea L.Onze-horashypertensionInfusion (I)3110.17
 80.1. Roupala montana Aubl.Carne-de-vacamuscular relaxativeInfusion (I)2110.17
 81.1. Punica granatum L.Romãcolic, diarrhea, pain, throat, inflammation uterina, and kidneysInfusion and maceration (I, E)41 3 6 0.70
 82.1. Rhamnidium elaeocarpum ReissekCabriteiroanemia, diarrhea, diuretic, pain, stomach, and wormsInfusion (I)37 560.90
 83.1. Rosa alba L.Rosa-brancawound healing, pain, and uterine inflammationInfusion and maceration (I, E)6 3 3 0.50
 83.2. Rosa graciliflora Rehder & E. H. WilsonRosa-amarelapainInfusion and maceration (I, E)1110.17
 83.3. Rubus brasiliensis Mart.Amoreiracholesterol, hypertension, labyrinthitis, menopause, obesity, osteoporosis, and kidneysInfusion and tintura (I)38 6 7 1.07
 84.1. Chiococca alba (L.) Hitchc.Caincapain, flu, and rheumatismInfusion (I)8330.50
 84.2. Cordiera edulis (Rich.) KuntzeMarmeladawormsMaceration and syrup (I)3110.17
 84.3. Cordiera macrophylla (K. Schum.) KuntzeMarmelada-espinhowormsMaceration and syrup (I)1110.17
 84.4. Cordiera sessilis (Vell.) KuntzeMarmelada-bolaFlu and wormsMaceration and syrup (I)4220.33
 84.5. Coutarea hexandra (Jacq.) K. Schum.MurtinhadiarrheaInfusion (I)1110.17
 84.6. Genipa americana L.Jenipapoappendicitis bronchitis diabetes and kidneysInfusion and syrup (I)8440.67
 84.7. Guettarda viburnoides Cham. & Schltdl.Veludo-brancoblood cleanser and ulcerInfusion (I)5220.33
 84.8. Palicourea coriacea (Cham.) K. Schum.Douradinha-do-campoprostate cancer hearth, blood cleanser, diuretic, flu, hypertension, insomnia, relaxative muscular, and kidneysInfusion (I)62 7 9 1.30
 84.9. Palicourea rigida KunthDoradãoKidneys and coughInfusion and decoction (I)5 2 2 0.33
 84.10. Rudgea viburnoides (Cham.) Benth.Erva-molarcolumn, thooth, blood cleanser, dysentery, rheumatism, and kidneysInfusion (I)44 5 6 0.90
 84.11. Tocoyena formosa (Cham. & Schltdl.) K. Schum.Jenipapo-bravokidneysInfusion (I)1110.17
 84.12. Uncaria tomentosa (Willd. ex Roem. & Schult.) DC.Unha-de-gatointoxication, rheumatism, and kidneysInfusion (I)10330.50
 85.1. Citrus aurantiifolia (Christm.) SwingleLimasoothing hearth, and hypertensionInfusion (I)8230.40
 85.2. Citrus limon (L.) OsbeckLimãocolic, diabetes, pain, liver, flu, hypertension, and coughInfusion (I)17570.97
 85.3. Citrus sinensis (L.) OsbeckLaranjasoothing wound healing, fever, flu, pneumonia, and thyroidInfusion (I)30 4 6 0.80
 85.4. Ruta graveolens L.Arrudacolic, conjunctivitis, pain, stomach, fever, gastritis, nausea, and laxative muscularInfusion (I)57 4 8 0.93
 85.5. Spiranthera odoratissima A.St.-Hil.ManacárheumatismInfusion (I)6110.17
 85.6. Zanthoxylum cf. rhoifolium Lam.Mamica-de-porcadiabetes, diarrhea, hemorrhoids, and muscular relaxativeDecoction (I, E)12 4 4 0.67
 86.1. Casearia silvestris Sw.Chá-de-fradeblood cleanser, pain, and feverInfusion (I)10130.30
 87.1. Dilodendron bipinnatum Radlk.Mulher-pobrebone fracturesInfusion (I)5220.33
uterine inflammation
 87.2. Magonia pubescens A. St.-Hil.Timbówound healing, pain, and coughMaceration (I, E)7230.40
 87.3. Serjania erecta Radk.Cinco-pontascolumn, muscular relaxative, and kidneysInfusion (I)9230.40
 87.4. Talisia esculenta (A. St.-Hil.) Radlk.Pitombacolumn, pain, and rheumatismInfusion (I)6230.40
 88.1. Pouteria glomerata (Miq.) Radlk.Laranjinha-do-matofeverInfusion (I)1110.17
 88.2. Pouteria ramiflora (Mart.) Radlk.Fruta-de-viadoUlcer and kidneysInfusion (I)1220.33
 89.1. Bacopa sp.Vicki-de-batatakidneysInfusion (I)2110.17
 89.2. Scoparia dulcis L.Vassorinhabladder wound healing, hearth, blood cleanser, diabetes, pain, bone fractures, swelling in pregnant woman, pneumonia, kidneys, syphilis, and coughInfusion (I)81 7 12 1.50
 90.1. Simaba ferruginea A. St.-Hil.Calungaanemia, wound healing, diabetes, digestive, pain, stomach, obesity, ulcer, and wormsMaceration (I)31 7 9 1.30
 90.2. Simarouba versicolor A. St.-Hil.Pé-de-perdizwound healing and uterine inflammationDecoction (I, E)4 2 2 0.33
 91.1. Siparuna guianensis Aubl.Negraminapain, fever, and fluInfusion (I)20230.40
 92.1. Smilax aff. brasiliensis Spreng.JapecangaColumn and rheumatismInfusion (I)5120.23
 93.1. Capsicum sp.PimentaPain and hemorrhoidsInfusion (I, E)14220.33
 93.2. Nicotiana tabacum L.FumothyroidInfusion (I, E)2110.17
 93.3. Physalis sp.Tomate-de-capotehepatitisInfusion (I)1110.17
 93.4. Solanum americanum Mill.Maria-pretinhawormsInfusion (I)3110.17
 93.5. Solanum lycocarpum A. St.-Hil.Fruta-de-loboGastritis and ulcerInfusion and maceration (I)6120.23
 93.6. Solanum sp.Jurubebacolumn, stomach, and liverInfusion (I)8230.40
 93.7. Solanum sp.UrtigaboiInfusion (I)1110.17
 93.8. Solanum melongena L.BerinjelacholesterolInfusion and maceration (I)2110.17
 93.9. Solanum tuberosum L.Batata-inglesaPain and gastritisInfusion and maceration (I, E)13220.33
 93.10. Solanum viarum Dunal.Joá-mansoHemorrhoidsInfusion (I)7110.17
 94.1. Apeiba tibourbou Aubl.JangadeiraliverDecoction (I, E)1110.17
 94.2. Luehea divaricata Mart.Açoita-cavalouric acid, column, blood cleanser, throat, flu, hemorrhoids, intestine, pneumonia, muscular relaxative, kidneys, cough, and tumorsDecoction and syrup (I)58 7 12 1.50
 95.1. Trema micrantha (L.) BlumePiriquiteirawound healingDecoction (I, E)1110.17
 96.1. Casselia mansoi SchauSaúde-da-mulherthooth, blood cleanser, uterine inflammation, and menstruationInfusion (I)9 3 4 0.57
 96.2. Duranta repens L.Pingo-de-ourodiabetesInfusion (I, E)3110.17
 96.3. Lantana camara L.Cambarácold and coughDecoction (I)22220.33
 96.4. Lippia alba (Mill.) N. E. Br. ex Britton & P. WilsonErva-cidreirasoothing hearth, thooth, blood cleanser, pain, flu, hypertension, tachycardia, and coughInfusion (I)75 5 9 1.10
 96.5. Phyla sp.Chá-mineiroconjunctivitis, blood cleanser, pain, fever, muscular relaxative, rheumatism, and kidneysInfusion (I)19 4 7 0.87
 96.6. Priva lappulacea (L.) Pers.Pega-pegaStomach and sinusitisInfusion (I)2220.33
 96.7. Stachytarpheta aff. cayennensis (Rich.) VahlGervãobronchitis blood cleanser, stomach, liver, bone fractures, gastritis, flu, constipation, relaxative muscular, cough, and wormsInfusion (I)80 6 11 1.33
 96.8. Stachytarpheta sp.Rabo-de-pavãorelaxative muscularInfusion (I)3110.17
 96.9. Vitex cymosa Bert.ex Spregn.Tarumeiroblood cleanser, diarrhea, pain, and stomachInfusion (I)8340.57
 97.1. Anchietea salutaris A. St.-Hil.Cipó-sumacolumn, blood cleanser, fever, intoxication, and vitiligoInfusion (I)18450.73
 97.2. Hybanthus calceolaria (L.) Schulze-Menz.Poaia-brancacoughInfusion (I)1110.17
 98.1. Cissus cissyoides L.Insulina-de-ramodiabetesInfusion (I)10110.17
 98.2. Cissus gongylodes Burch. ex BakerCipó-de-arráiarelaxative muscularInfusion (I)1110.17
 98.3. Cissus sp.Rabo-de-arráiahypertensionInfusion (I)3220.33
 98.4. Cissus sp.Sofre-do-rim-quem-querinflammation uterina, relaxative muscular, and kidneysInfusion (I)5 3 3 0.50
 99.1. Callisthene fasciculata Mart.Carvão-brancoHepatitis and icterusDecoction (I, E)10220.33
 99.2. Qualea grandiflora Mart.Pau-terraDiarrhea and painDecoction (I, E)5220.33
 99.3. Qualea parviflora Mart.Pau-terrinhadiarrhea1110.17
 99.4. Salvertia convallariodora A. St.-Hil.Capotãodiarrhea, diuretic, hemorrhoids, and relaxative muscularDecoction (I, E)4 4 4 0.67
 99.5. Vochysia cinnamomea PohlQuina-doceflu3110.17
 99.6. Vochysia rufa Mart.Pau-doceblood cleanser, diabetes, diarrhea, laxative, obesity, kidneys, cough, and wormsDecoction, Infusion (I, E)25 6 8 1.13
 100.1. Aloe barbadensis Mill.BabosaCancer, prostate cancer, wound healing, diabetes, stomach, bone fractures, gastritis, hepatitis, laxative, and rheumatismSyrup and maceration (I, E)87 5 9 1.10
 101.1. Zamia boliviana (Brongn.) A. DC.MaquinéstomachInfusion (I)2110.17
 102.1. Alpinia speciosa (J. C. Wendl.) K. Schum.Colôniasoothing hearth, fever, flu, and hypertensionInfusion (I)36 4 5 0.73
 102.2. Curcuma longa L.Açafrãocolumn, diuretic, pain, stomach, and hepatitisInfusion and maceration (I)18450.73
 102.3. Zingiber officinale RoscoeGengibrepain, flu, sinusitis, and coughInfusion and maceration (I)26240.47

I: Internal, E: External; NSC: Number of body systems treated by species; NCS: number of body systems. NP: Number of properties of the species; RI: Relative importance of the species.
3.1. Relative Importance (RI)

The RI of the species cited by 262 respondents from NSACD ranged from 0.17 to 1.87. A total of 261 species had RI ≤ 0.5; 80 species, RI from 0.51 to 1.0; 30 species, RI from 1.1 to 1.5, and 4 species with RI from 1.51 to 2.0, among the latter, three species were native to Brazil. The species with RI ≥ 1.5, were Himatanthus obovatus (Müll. Arg.) Woodson (1.87), Hibiscus sabdariffa L. (1.87), Solidago microglossa DC. (1.80), Strychnos pseudoquina A. St.-Hil. (1.73), Dorstenia brasiliensis Lam., Scoparia dulcis L., and Luehea divaricata Mart. (1.50 each), as shown in Table 4.


Apocynaceae Himatanthus obovatus (Müll. Arg.) Woodsonanemia (1), wound healing (7), cholesterol (3), blood cleanser (9), pain (4), nose bleeding (1), hypertension (4), uterine inflammation (5), labyrinthitis (6), muscle relaxant (2), worms (1), vitiligo (1), and pneumonia (1) 45 1.87
Malvaceae Hibiscus sabdariffa Lanxiety/heart (1), flu (1), tachycardia (1), kidneys (1), cramps (3), discharge (1), diarrhea (1), pain (1), inflammation uterine (2), labyrinthitis (3), snakebite (1), and pneumonia (2) 18 1.87
Asteraceae Solidago microglossa DC.wound healing (53), blood cleanser (11), pain (2), bone fractures (1), hypertension (1), uterine inflammation (3), muscle relaxant (6), kidneys (3), and worms (2) 82 1.8
Loganiaceae Strychnos pseudoquina A. St.-Hil.anemia (46), wound healing (3), cholesterol (1), blood cleanser (16), pain (13), stomach (3), bone fractures (1), flu (2), uterine inflammation (1), pneumonia (1), muscle relaxant (1), cough (10), ulcer (1), and worms (8) 107 1.73
Moraceae Dorstenia brasiliensis Lam.wound healing (1), colic (1), tooth ache (1), blood cleanser (4), dysentery (1), pain (7), flu (2), laxative (3), menstruation (1), pneumonia (6), relapse delivery (13), and kidneys (1) 41 1.5
Plantaginaceae Scoparia dulcis L.heart (6), blood cleanser (1), diabetes (1), pain (16), bone fractures (47), swelling in pregnant woman (4), pneumonia (1), kidneys, ( 1) syphilis (3), and cough (1) 55 1.5
Malvaceae Luehea divaricata Mart.uric acid (18), vertebral column (2), blood cleanser (1), throat (1), flu (1), hemorrhoids (7), intestine (1), pneumonia (8), muscle relaxant (2), kidneys (3), cough (10), and tumors (4) 58 1.5

RF: Relative frequency; RI: Relative importance of the species.
3.2. Informant Consensus Factor (ICF)

In the disease categories according to CID, 10th ed., we observed that ICF values ranged from 0.43 to 0.77, with the exception of disease category included in CID VI (diseases of the nervous system), which was 0.13. The ICF for CID VI ranged between 0.13 and 0.78 (mean = 0.62, SD = 0.16, 95% CI: 0.53–0.70). The highest consensus value obtained was for the category related to injuries, poisoning, and some other consequences of external causes (ICF = 0.78), with 65 species and 286 citations. Three species were more common, namely, S. dulcis and S. microglossa (“Brazilian arnica”), with 49 citations each and L. pacari (manga-brava) with 42 citations. The main ailments addressed in this category were inflammation, pain, and gastric disorders.

Out of 20 disease categories, there were citations for 18 therapeutic indications, as shown in Table 5.

Disease category/CID, 10th ed.Medicinal plantsMain indicationsMain forms of usePart utilized/ State of the plantSpecies/citationsICF

Injuries, poisoning, and certain other consequences of external causes— XIXScoparia dulcis L. Solidago microglossa D. C Lafoensia pacari A. St.-Hil.inflammation and painInf, Dec, Mac, and TinL, Wp, Rt (Fr, Dr)65/2860.78
Mental and behavioural disorders —VChamomilla recutita (L.) Rauschert.soothingDec and InfL (In, Sc)20/850.77
Symptoms, signs, and abnormal clinical and laboratory findings not elsewhere classified—XVIIIMacrosiphonia longiflora (Desf.) Müll. Arg.blood depurativeInf, Dec, and MacRz (Fr, Dr)176/7130.75
Diseases of the genitourinary system —XIVPalicourea coriacea (Cham.) K. Schum.Kidneys and diureticInf, Dec, and SyrL (Fr, Dr)132/5330.75
Diseases of the digestive system—XIPlectranthus barbatus Andrewsstomach, pain, liver, and malaiseDec, Inf, Mac, and JucL (Fr, Dr)113/4280.74
Other infectious and parasitic diseases—IChenopodium ambrosioides L.verminoseInf, Mac, and JucL (Fr,Dr)82/3000.73
Diseases of the respiratory system—XMentha pulegium L.flu, bronchitis, colds, and coughDec, Inf, Mac, and SyrL (Fr, Dr)88/303 0.71
Pregnancy, childbirth, and the puerperium—XVDorstenia brasiliensis Lam.childbirthDec, Inf, and SyrRz (Fr, Dr)9/280.70
Diseases of the circulatory system—IXAlpinia speciosa (J. C. Wendl.) K. Schum.Hypertension and heartInf and MacL (Fr, Dr)56/1800.69
Some disorders originating in the perinatal period—XVIBidens pilosa L.Hepatitis and entericDec and InfL (In, Sc)3/70.67
Diseases of blood and blood forming organs and certain disorders involving the immune system—IIIStrychnos pseudoquina A. St.-Hil.anemiaInf, Mac, and SyrB (Fr, Dr)15/380.62
Diseases of the eye and the surrounding structures—VIIMalva sylvestris L.Discharge and conjuctivitisInf and TinL (Fr, Dr)6/140.61
Diseases of endocrine of nutritional and metabolic origins—IVCissus cissyoides L.diabetesInfL (Fr, Dr)47/1090.57
Diseases of the ear and mastoid process—VIIIHimatanthus obovatus (Müll. Arg.) WoodsonlabyrinthitisInfL (Fr, Dr)7/15 0.57
Diseases of musculoskeletal and connective tissue—XIIISolidago microglossa DC.bone fracturesDec, Inf, Mac, and TinL (Fr, Dr)70/1460.52
Diseases of the skin and subcutaneous tissue—XIIDioscorea brasiliensis Willd.furunculesDec, Inf, Mac, Tin, and OutRz (Fr, Dr)29/510.44
Neoplasia (tumors)—IIAloe barbadensis Mill.wound healingDec, Inf, Mac, Tin, and OutL (Fr, Dr)22/380.43
Diseases of the nervous system—VIMacrosiphonia longiflora (Desf.) Müll. Arg.leakageInf14/160.13

CID, 10th ed. categories of diseases in chapters according to International Classification of Diseases and Related Health Problems, 10th. edition [25]; ICF: informant consesus factor; Inf: infusion, Dec: decoction, Syr: syrup, Mac: maceration, Sal: salad, Tin: tinture, Juc: juice, Out: others (compression and bath). L: leave; Wp: whole plant; Rt: root; Rz: rhizome; B: bark. State of the plant: Fr: fresh; Dr: dried.

4. Discussion

In the present study, almost all the respondents (99%) claimed to know and use medicinal plants. Surveys conducted in other countries had reported values ranging from 42% to 98% depending on the region and country of the study [2527]. Due to the low level of knowledge of traditional medicine in national capitals, ethnobotanical surveys in many developing countries including Brazil, primarily prefer to evaluate small communities or rural hometowns, whose population having knowledge and practical experience with traditional medicine are proportionately higher (between 80 and 100%) [2830].

The high percentage of folk knowledge of medicinal plants identified in Brazil may be due to factors such as lower influence of the contemporary urban lifestyle and the strength of cultural traditions in the rural communities [31]. In fact, with the process of industrialization and migration to the cities, a significant part of traditional culture is maintained more in the communities farther from the metropolis via oral transmission of the knowledge of CAM and family traditions. Transmission and conservation of CAM knowledge is more pronounced in Brazil due to high degree of biodiversity.

One of the most important aspects of this research is the documentation of high number of taxa (285 genera and 102 families) and species (376) mentioned by the informants as medicinal. These findings confirmed the existence of the great diversity of plants used for therapeutic purpose and preserved traditional culture, as stated by Simbo [32]. It is worth mentioning here the presence of 8 (eight) local medicinal plant expert informants/healers among the 262 respondents in this study. These local expert informants/healers account for a significant number of citations (43 to 250) in this study. In Brazil, as in other countries, rural communities have developed knowledge about the medicinal and therapeutic properties of natural resources and have contributed to the maintenance and transmission of the ethnopharmacological knowledge within the communities.

The most representative plant families are Fabaceae (10.2%), Asteraceae (7.82%), and Lamiaceae (4.89%). These results are in accordance with other ethnobotanical surveys conducted in the tropical regions [33, 34] including Brazil [7, 35]. Furthermore, the results from our study are also in conformity with the findings of the most comprehensive ethnobotanical survey conducted by V. J. Pott and A. Pott in the Brazilian Pantanal region [19].

Featuring greater potential for bioprospecting are 231 (61.6%) species indicated for the treatment of at least two diseases, and RI between 0.17 and 1.87 (mean = 0.46, SD = 0.357, 95% CI: 0.4250–0.4973). The seven species with the highest RI were H. obovatus (Müll. Arg.) Woodson (13 therapeutic indications and RI = 1.87, H. sabdariffa L. (12 therapeutic indications and RI = 1.87); S. microglossa DC. (9 therapeutic indications and RI = 1.80) S. pseudoquina A. St. - Hil. (14 therapeutic indications and RI = 1.73) and D. brasiliensis Lam., S. dulcis L., and L. divaricata Mart. (12, 10, and 12 therapeutic indications respectively with RI = 1.50) (Table 4). For the sake of brevity, we will focus most of our discussion on these seven most cited medicinal plants highlighting the most important available literature on them and including L. pacari. It should be noted that although 146 (39%) species presented RI below 0.17, with just a single indication, they cannot be considered as of lower pharmacological potential or importance, because as Albuquerque et al. [36] have noted elsewhere, these may be species of recent introduction in the culture of the community under study but might have been validated by the customary use in other social groups.

A total of 105 different folkways, including 18 disease categories, according to Brasil [24], were codified as shown in Table 5. The highest frequencies in decreasing magnitude were indications for the treatment of pain and inflammation (10.8%), kidney disease (7.6%), and wound healing (6.8%). In part, these data can be explained by the characteristics of the informants (elderly, rural activity, low level of education, and poor sanitation at home) with higher frequency of chronic, inflammatory, and infectious diseases. In addition, the search for natural treatments for infected wounds is very common in populations of agrarian labor or menial worker as stated by Akerreta et al. [37]. As ICF values were generally close to 1.0, it may be presumed that there is certain homogeneity in knowledge of medicinal plants among the population of NSACD.

4.1. Literature Survey and Discussions on the Selected Species with Higher Relative Importance

Himatanthus obovatus, var. obovatus had the highest relative importance, being cited for 13 different ailments that fall into 11 categories of CID, 10th ed. with a total of 29 citations. The most commonly mentioned of these indications for this plant were its traditional use as a blood cleansing, wound healing, and other conditions associated with infections, which seems to point to its possible antibiotic activity. Indeed, some studies have demonstrated the in vitro activity of its different extracts against promastigotes of Leishmania donovani [38]. A few others also showed experimentally its antiviral, antitumor activities, cellular proliferation activities, and inflammatory and immune response [39, 40]. On the basis of these aforementioned, it is possible that its use in the folk medicine may be related to its ability to modulate the immune system, which may enhance physiological mechanisms involved in resolving inflammation, pain, and wound healing. We did not encounter any literature pertaining to its use in anemia, nosebleeding, muscle relaxant, deworming, or vitiligo treatment. Its indications as a blood cleansing and as antihypercholesterolemic are important targets for future biomedical research.

Hibiscus sabdariffa calyces are used in many parts of the world to make cold and hot drinks as well as in folk medicine [41]. Due to its many health-enhancing benefits, extensive works have been carried to validate its traditional therapeutic claims. In fact, its medicinal importance is widely acknowledged in many traditional herbal systems [42].

The benefits associated with the use of H. sabdariffa may in part be due to its high content of beneficial phytochemical constituents. These include alkaloids, L-ascorbic acid, anisaldehyde, anthocyanin, β-carotene, β-sitosterol, citric acid, cyanidin-3-rutinoside, delphinidin, galactose, gossypetin, hibiscetin, mucopolysaccharide, pectin, protocatechuic acid, polysaccharide, quercetin, stearic acid, and flavonoids [42, 43]. Studies have highlighted the role of polyphenol acids, flavonoids, and anthocyanins that may act as antioxidants or through other mechanisms that may contribute to its cardioprotective activity [44, 45].

In additions to folkloric use of H. sabdariffa noted in this study, other previous reports have indicated its use in the treatment of liver disease, hypocholesterolemic, antispasmodic, intestinal antiseptic, sedative, and as mild laxative [42, 46]. The most extensively studied is its antihypertensive activity. This effect was confirmed in several in vitro and animal studies [4749]. The hypotensive effect of H. sabdariffa and its constituents may be mediated, at least partially, by a cholinergic and/or histaminergic mechanism and it has been confirmed to act via inhibitiory action on angiotensin I converting enzyme, vasorelaxation [50], and diuretic action [51]. For detailed review on this aspect, see [41]. In addition to literature reports on the medicinal uses of this plant, we also report here its indications in the treatment of anxiety and labyrinthitis and as anti-snake venom. To the best of our knowledge, these indications remained to be proven experimentally.

In concordance with the traditional use of H. sabdariffa in the treatment of uterine inflammation and pain, its aqueous ethanol extract was shown experimentally to presents anti-inflammatory, uterine antispasmodic activities, and attenuation of intestinal spasm [5254]. In addition to its confirmed pharmacological activities, its antiobese/weight-reducing [50, 55], hepatoprotective [5658], anticancer [46, 59, 60], free-radical scavenging [61], antioxidant [42], immunomodulatory [62], lipid-lowering [43, 63] effects and attenuation of oxidants-mediated complications in diabetes [64] have been well documented. Besides, the plant extract is characterized by a very low degree of toxicity [41]. Moreover, apart from its medicinal uses, the plant seed oil was also shown to be a good source of lipidsoluble antioxidants, particularly γ-tocopherol, thus it could have important industrial applications [65].

Solidago microglossa is popularly known in Brazil as “arnica,” “arnica-do-mato,” “arnica-silvestre,” “erva-federal,” “arnica-vulgar,” “erva-lanceta,” and “rabo-de-rojão” [66]. It is usually confused with Arnica montana L., a native of the mountainous regions of Europe, due to the similarity in their medicinal flowers and having the same color (yellow), S. microglossa is not cultivated in Brazil due to it low adaptation to the tropical conditions [66]. In our study, S. microglossa was indicated for treatment of 15 different diseases corresponding to 8 classes of CID, 10th ed. and had a total of 49 citations. The key citations for this plant were its use in wound healing and blood cleansing. Other popular indications found in this study were similar to those previously reported, especially its use in the treatment of wounds, acne, bruises, and stomach-related ailments [67].

Several classes of compounds and metabolites have been isolated from S. microglossa, especially phenols, acetophenones, carotenoids, lactones (helenalin and dihydro-helenalin) [68, 69], flavonoids [70, 71] saponins [72], and polyacetylenes [70]. The cicatrizant activity of the plant’s extract has been confirmed experimentally [73]. Although not mentioned directly by respondents in this study, some lines of evidence suggest important antibiotic activity with the use of S. microglossa, which can justify its indication for uterine inflammation. Morel et al. [74] showed that the essential oil of S. microglossa and three of its components (quercetrin, α-espinasterol, and solidagenone) are capable of significantly inhibiting the growth of Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, Escherichia coli, Salmonella setubal, Bacillus subtilis, Pseudomonas aeruginosa, Saccharomyces cerevisiae, and Candida albicans [74]. In addition, cicatrizant activity was observed with the administration of the plant’s extract [73]. Its use in ameliorating renal ailments, blood cleansing, and hypotensive and antiparasitic activities may be associated with the presence in high concentrations of tannins [75, 76] and flavonoids in this species [7679]. Its indication for muscle relaxation may also derive from its antispasmodic effect [80]. Further studies are warranted in these regards.

Other pharmacological properties not mentioned here, but have been established in preclinical studies, include hypoglycemic effect [81] and antitumor activity. In fact, the latter effect has attracted intense interest in the discovery of new chemotherapeutic agents. The extract of S. microglossa demonstrated antiproliferative effect (but not mutagenic) against young shoot cells of onion (Allium cepa) strain [82]. Some of these activities may be related to the presence of secondary metabolites such as helenalin [83].

Although Strychnos pseudoquina is referred to locally as “quinas”, similar to the local name used for species such as Cinchona sp. (source of quinine), it has been shown to be inactive against Plasmodium berghei [84] contrary to its popular use in folk medicine elsewhere [84]. Theoretically, some of the indications may result from the classification bias in the community due to an erroneous popular cultural belief that plants referred to as “quinas” are useful for “anemic” patients infected with malaria parasite. This perhaps helps to explain why the highest indication for this plant in our study was to treat anemia.

Among the components isolated from S. pseudoquina metabolites are isoramnetin, strychnobiflavone, and 11-diaboline metoxidiaboline [85]. Silva et al. [86] demonstrated the gastroprotective effect of S. pseudoquina in models of gastric lesions induced by nonsteroidal anti-inflammatory agents and some necrotizing agents, thus confirming its indication for gastric ulcer and stomach disorders as noted in this present study. On the other hand, its indication in wound healing has not been experimentally confirmed at least in the diabetic wound model in rats [87] or in local hemorrhage induced by Bothrops jararaca venom [88]. Other medicinal uses indicated like “blood depurative” and analgesic effect may be subject of future investigation as a potential agent with antinociceptive and metabolic disorders ameliorating effects. Regarding its toxicity, Santos et al. [81] showed that only the methanol extract (but not dichloromethane) from the leaves of S. pseudoquina have mutagenic effect in Salmonella strains TA98 (−S9) and TA100 (+ S9, −S9) and that it induces formation of micronuclei after acute treatment [81].

Dorstenia brasiliensis, known as “Carapiá” is a perennial herb of the early geological point of view, typical of the fields in southern Brazil, Paraguay, Uruguay, and Argentina [89, 90]. Phytochemical analysis of roots of D. brasiliensis indicated the presence of dorstenic acid A and B (triterpenoids), isopimarane-type diterpenoid, and six different types of coumarins. The two triterpenoids showed moderate cytotoxicity against leukemia cells (L-1210 and HL-60) [91]. Furthermore, some authors have suggested that its use in cutaneow disease (such as psoriases and vitiligo) may be associated with the presence of furanocoumarins in the species of Dorstenia [92]. Bartericin A and B, stigmasterol, isobavachalcone, 4-hydroxylonchocarpin, dorsmanin F, 6,8-diprenyleridictyol, quercetin, quercitrin, amentoflavone [93], psoralen, bergapten (from rhizome), and umbelliferone [94] are some of the compounds isolated this medicinal plant.

Some few pharmacological studies have demonstrated analgesic and anti-inflammatory activities of D. brasiliensis in animal models [95]. These data corroborated the popular use of D. brasiliensis as an analgesic. There is dearth of information confirming its use in the popular medicine use as an anti-inflammatory agent. Moreover, D. brasiliensis may possesses some biologically active compounds similar to other Dorstenia species from the same genus and may thus share similar pharmacological profile. The following compounds and pharmacological activities have been reported in other Dorstenia species: chalcones (D. prorepens and D. zenkeri) [96], furocoumarins (D. bahiensis and D. bryoniifolia), triterpenes (D. bahiensis, D. bryoniifolia, D. carauntae, D. cayapiaa, and D. heringerii) [97]. This is a point to be noted for future research. Some authors have investigated its potential use as antivenom, antiinfective, anti-rheumatic [96, 97] while others established its antitrichomonal [93], antitussive [98], antioxidant [93, 99] and antileishmanial [100] activities.

Scoparia dulcis, popularly known as “vassourinha”, grows wild in backyards, gardens, and fields in Brazil. Phytochemical studies have identified the presence of more than 12 interesting pharmacologically active compounds in this species, namely, scoparic acid A [101], iso-dulcinol, 4-epi-scopadulcic acid B, dulcidiol, scopanolal, dulcinol/scopadulciol, scopadiol [102], scoparinol [103], scopadulcic acid B [104106], glutinol [107] and scopadulin [105]. Scopadulcic acid B inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro and in vivo, and also suppressed the promoting effect of TPA on skin tumor formation, demonstrating stronger effect than antitumor-promoting terpenoids, such as glycyrrhetinic acid [104]. In fact, its cytotoxicity has been investigated against antitumor activity [102] and nerve growth factor-mediated neurite outgrowth and neurodegenerative disorders [103, 108].

The analgesic and anti-inflammatory activities of ethanol extracts of S. dulcis and glutinol have been demonstrated in writhing induced by acetic acid and carrageenan-induced paw edema, respectively [107]. However, S. dulcis extracts were ineffective in the central pain models (tail flick) and paw edema induced by dextran. Another secondary metabolite, scoparinol, also showed significant analgesic and anti-inflammatory activity [109]. In regard to its toxicological effects, it is worthwhile to mention that glutinol and scoparinol markedly potentiated pentobarbital-induced sedation and duration of sleeping time in these two studies mentioned above.

In contrast to its toxicity, S. dulcis seems to possess potential hepatoprotective activity in different models, which have been attributed to its free-radical scavenging potential activities [110113]. Corroborating with antibiotic use for some infections (like gonorrhea), some authors have investigated inhibition of multidrug resistance (MDR) bacteria, fungi [114, 115], leishmanial parasite [116], and herpes simplex virus type 1 growths [96].

Paradoxically, despite the low citation in gastric ulcer and diabetes treatments in this study, the antiulcer and antihyperglycemic activities of this species are well documented. Inhibitory activities of S. dulcis extracts was demonstrated in pylorus ligature model, histamine- or bethanechol-stimulated gastric secretion, and acute gastric lesions induced by indomethacin [117, 118]. S. dulcis was also demonstrated to inhibit both proton pump (H+, K+-ATPase) and proton transport into gastric vesicles [105]. In regard to its antihyperglycemic effect, experimental evidences demonstrated that S. dulcis extracts reduced blood glucose, glycosylated haemoglobin, prevented decrease in the body weight, and improved glucose tolerance similarly with glibenclamide [119]. Even in the insulin resistance stage, S. dulcis-treated L6 myotubes were found to be more capable of stimulating glucose transport than insulin treatment [120]. In addition, scoparic acid D was able to stimulate insulin secretion and receptor binding in streptozotoci- (STZ-) induced diabetic rats [121].

Luehea divaricata is a native tree of the Brazilian Cerrado popularly known as “açoita-cavalo”. Just as popularly indicated, some studies have reported the following pharmacological activities of L. divaricata: the leaves as used as diuretic, the stems as anti-inflammatory, the bark and aerial parts are used for healing skin wounds, pimples, and for vaginal washes [122, 123].

Phytochemical screening of L. divaricata reported the presence of flavonoids, tannins and saponins and afforded the presence of 3b-p-hydroxybenzoyl-tormentic acid [124], maslinic acid [122], vitexin and glucopyranosylsitosterol, and (−)-epicatechin [123].

The presence of flavonoids and metabolites such as the vitexin [125, 126] and maslinic acid [127, 128] may be associated with the popular indication of its anti-inflammatory properties formation of urate (18) and antitumor (4). Extracts of L. divaricata has been shown to have antioxidant activity and analgesic property [129], lack toxicity in vivo [130], or mutagenicity [131]. Its extract also showed cytotoxicity against tumor cell lines [123]. Due to the high level of citation for the treatment of urate aleviation (18), we believe that its antigout or uricosuric activity may be an important target of pharmacological interest. Another indication prominently cited by the respondents is the use of L. divaricata in the treatment of lung diseases and upper airway. However, there is no scientific evidence on its regulatory activity on cough, while its antibiotic properties also vary. Some authors have demonstrated its inhibitory effect on the growth of dermatophytes [132] but not in other fungi species [123, 129]. In addition, the extract of L. divaricata was shown to strongly inhibit the growth of S. aureus, S. epidermitis, K. pneumonia, and E. coli in a study [129] but showed only moderately in another study elsewhere [123].

It is worth mentioning that although Lafoensia pacari A.St.-Hil. had low relative importance value, all the same, it is among the three plants with the highest informant consesus factor in addition to being a native plant in the region. The other two (S. dulcis and S. microglossa) have been discussed previously.

L. pacari popularly called “mangava-brava”, belongs to the family Lythraceae, is a tree native to the Brazilian Cerrado [133]. It is commonly used for gastrointestinal disorders, wound healing, diarrhea, and kidney problems. In our study, it was referenced for the treatment of seven disorders distributed into five classes of CID, 10th ed. Preliminary phytochemical studies of methanol extract of the stem bark of L. pacari revealed the presence of free steroids, saponins, tannins catechins, pyrogalic tannins (in particular, ellagic acid), triterpenoids, simple phenols, strong and weak fixed acids, alkali, and quaternary amino acids [134136]. Acute toxicity studies or subchronic oral administration of extracts of L. pacari did not indicate any harmful effects [137]. However, it is also indicated for its adverse reactions and used as an abortifacient, diarrheic, weight loss, and tachycardia. Among the 42 citations for L. pacari, 29 were for the treatment of ulcer, and four and two for gastritis and stomach, respectively. These indications have been confirmed with the use of methanol crude extract of L. pacari and its major active components, ellagic acid, in different experimental ulcer models [138143]. In addition, the antiulcer activity of the methanol extract (capsules) of L. pacari was confirmed in the clinical trial with 55 patients with dyspepsia [144].

We did not encounter any studies concerning its activities in wound healing, antidiarrheal or alleviation of kidney disorders. This phenomenon of plant selection by local people for certain indications may be, for instance, to consolidate best practice of the medicinal properties of the plants at the expense of using other plants substitute for these indications. In fact, the broad community access to Amazon or Pantanal biome, and the close relationship with the indigenous native populations, promotes a variety of possibilities of ethnobotanical indications. Examples of other popular uses of L. pacari that have been experimentally confirmed includes weight loss [145], anorectic effect [142], antipyretic activity [146], anti-inflammatory [147], antiallergic [148], and analgesic property [149].

It is also worth mentioning other studies focused on the medicinal uses of L. pacari, including its potent antifungal activity [150], have demonstrated that the main compound responsible is found in the methanol extract of this plant. A patent application of lotion with the infusion prepared from the leaves of L. pacari, as a component of the formulation was also solicited [151]. To the best of our knowledge, there is currently no available literature concerning its claims as wound healing, antidiarrheal, or in kidney disorders.

5. Conclusions

The present study identified the several plant species and their medicinal uses in NSACD highlighting significant cultural diversity in the Pantanal region. In fact, one of the important components of this community is the contribution of Amerindian culture, which highlights its importance in the identification of indigenous popular knowledge relevance in the identification of native popular knowledge.

Analytically, the data were categorized according to the highest values of relative importance and consensus among informants, ensuring the best evidence for ethnobotanical bioprospecting of medicinal plants. Thus, we identified seven native species with the highest relative importance, which are H. obovatus, H. sabdariffa, S. microglossa, S. pseudoquina and D.brasiliensis, S. dulcis, and L. divaricata including L. pacari. The three plants with the highest value of consensus among informants were S. dulcis, S. microglossa, and L. pacari.

The preservation of local culture, the practice of traditional medicinal plant species themselves represent important strategies for sustenance of popular knowledge of CAM in the local systems of health care and environmental education. Moreover, ethnobotanical and pharmacological studies provide information essential for guidance in bioprospecting for new drugs of plant origin in the consolidation of therapeutic practices of the community.


The authors thank all the informants and staffs of Family Health Programme of NSACD, for the assistance and contributions made throughout ethnobotanical fieldwork, FAPEMAT and CNPq for granting scholarships, researcher, Dr. Rosilene Rodrigues Silva, UFMT Herbarium and Vali Joana Pott (MSc.) of CGMS Herbarium of Federal University of Mato Grosso do Sul, Campo Grande, for technical assistance in identification of plant species, National Institute for Science and Technology in Wetlands (INAU), National Council for Scientific and Technological Development CNPq/MCT, and Pantanal Research Center (CPP) for funding the research work.


  1. OMS, Organización Mundial DE La Salud. Estrategia de la OMS sobre medicina tradicional 2002–2005, OMS, Geneva, Switzerland, 2002.
  2. Brasil, “Ministério da Saúde. Portaria nº 971. Aprova a Política Nacional de Práticas Integrativas e Complementares no SUS,” Diário Oficial [da] República Federativa do Brasil, Poder Executivo, Brasília, DF, 2006. View at: Google Scholar
  3. U. Cakilcioglu and I. Turkoglu, “An ethnobotanical survey of medicinal plants in Sivrice,” Journal of Ethnopharmacology, vol. 132, no. 1, pp. 165–175, 2010. View at: Publisher Site | Google Scholar
  4. Brasil, “Flora, vegetação, etnobotânica-conservação de recursos vegetais no pantanal,” Cuiabá, 2006. View at: Google Scholar
  5. Mato Grosso, “Plano plurianual 2004–2007 do Governo do Estado,” Projeto de lei. Seplan, MT. 2005. View at: Google Scholar
  6. M. C. M. Amorozo, “Uso e diversidade de plantas medicinais em Santo Antônio do Leverger, MT,” Acta Botanica Brasílica, vol. 16, no. 2, pp. 189–203, 2002. View at: Google Scholar
  7. G. Guarim Neto, “O saber tradicional pantaneiro: as plantas medicinais e a Educação Ambiental,” REMEA. Julho a dezembro, FURG/PPGEA. 2006. View at: Google Scholar
  8. A. C. D. Diegues, O Mito Moderno da Natureza Intocada, Hucitec, São Paulo, Brazil, 1998.
  9. Poconé, “Plano Municipal de Saúde de Poconé. Prefeitura Muncipal de Poconé. Secretaria municipal de Saúde,” Poconé – MT, 2010. View at: Google Scholar
  10. R. L. Scheaffer, W. Mendnhall, and L. Ott, Elementos de Muestreo, Editora Iberoamericana, México, 1987.
  11. H. Bolfarine and W. O. Bussab, Elementos de amostragem, Edgar Blucher, São Paulo, Brazil, 2005.
  12. Brasil, “Ministério do Desenvolvimento, Indústria e Comércio,” Sistema Aliceweb: informações sobre o comércio exterior brasileiro. Brasília, 2007. View at: Google Scholar
  13. P. S. Levy and S. Lemeshow, Sampling of populations. Methods and Applications, John Wiley & Sons, New York, NY, USA, 2008.
  14. M. Pio Correa, “Dicionário das plantas úteis do Brasil e das exóticas cultivadas,” Instituto Brasileiro de Desenvolvimento Florestal, IBDF, Rio de Janeiro, 6 v.il. 1926–1969. View at: Google Scholar
  15. A. C. Diegues, “Etnoconservação na natureza: enfoques alternativos,” in Etnoconservação, novos rumos para a conservação da natureza nos trópicos, A. C. Diegues, Ed., pp. 1–46, Hucitec Nupaub-USP, São Paulo, Brazil, 2000. View at: Google Scholar
  16. A. M. Borba and M. Macedo, “Medicinal plants used for oral health in the Santa Cruz neighborhood, Chapada dos Guimarães, Mato Grosso State, Brazil,” Acta Botanica Brasilica, vol. 20, no. 4, pp. 771–782, 2006. View at: Publisher Site | Google Scholar
  17. M. C. Pasa, J. J. Soares, and G. Guarim Neto, “Estudo etnobotânico na comunidade de Conceição-Açu (alto da bacia do rio Aricá Açu, MT, Brasil),” Acta Botanica Brasilica, vol. 19, no. 2, pp. 195–207, 2004. View at: Google Scholar
  18. M. G. De La Cruz, Plantas Medicinais de Mato Grosso-A Farmacopéia Popular dos Raizeiros, Ed. Carlini e Caniato Editorial, 2008.
  19. V. J. Pott and A. Pott, Plantas do Pantanal, EMBRAPA-CPAP, Brasília, Brazil, 1994.
  20. A. Cronquist, The evolution classification of flowering plants, The New York Botanical Garden, New York, NY, USA, 2nd edition, 1988.
  21. Missouri Botanical Garden - MOBOT, April 2010, http://www.tropicos.org/.
  22. B. C. Bennett and G. T. Prance, “Introduced plants in the indigenous pharmacopoeia of northern South America,” Economic Botany, vol. 54, no. 1, pp. 90–102, 2000. View at: Google Scholar
  23. G. L. de Oliveira, A. F. M. de Oliveira, and L. H. C. Andrade, “Medicinal plants used in the urban community of Muribeca, Northeast Brazil,” Acta Botanica Brasilica, vol. 24, no. 2, pp. 571–577, 2010. View at: Google Scholar
  24. Brasil, “Classificação Internacional de Doenças e de Problemas Relacionados a Saúde,” Décima Revisão – CID-10, DATASUS. 2008. View at: Google Scholar
  25. D. M. Eisenberg, R. B. Davis, S. L. Ettner et al., “Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey,” Journal of the American Medical Association, vol. 280, no. 18, pp. 1569–1575, 1998. View at: Google Scholar
  26. G. A. Taddei-Bringas, M. A. Santillana-Macedo, J. A. Romero-Cancio, and M. B. Romero-Téllez, “Acceptance and use of therapeutic medical plants in family medical care,” Salud Publica de Mexico, vol. 41, no. 3, pp. 216–220, 1999. View at: Google Scholar
  27. T. H. Bekalo, S. D. Woodmatas, and Z. A. Woldemariam, “An ethnobotanical study of medicinal plants used by local people in the lowlands of Konta Special Woreda, southern nations, nationalities and peoples regional state, Ethiopia,” Journal of Ethnobiology and Ethnomedicine, vol. 5, article no. 26, 2009. View at: Publisher Site | Google Scholar
  28. I. G. C. Bieski, Plantas Medicinais e Aromáticas no Sistema Único de Saúde da Região Sul de Cuiabá-MT, Secretaria Municipal de Saúde de Cuiabá-MT, Lavras Minas Gerais – Brazil, 2005.
  29. G. S. Vendruscolo and L. A. Mentz, “Study of use citations agreement and importance of medicinal used species and families to the community of Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul State, Brazil,” Acta Botanica Brasilica, vol. 20, no. 2, pp. 367–382, 2006. View at: Publisher Site | Google Scholar
  30. E. B. Santos, G. S. Dantas, H. B. Santos, M. F. F. Melo Diniz, and F. C. Sampaio, “Etnobotanical studies of medicinal plants for oral conditions in the municipality of João Pessoa, Brazil,” Brazilian Journal of Pharmacognosy, vol. 19, no. 1B, pp. 321–324, 2009. View at: Publisher Site | Google Scholar
  31. B. Upadhyay, Parveen, A. K. Dhaker, and A. Kumar, “Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India,” Journal of Ethnopharmacology, vol. 129, no. 1, pp. 64–86, 2010. View at: Publisher Site | Google Scholar
  32. D. J. Simbo, “An ethnobotanical survey of medicinal plants in Babungo, Northwest Region, Cameroon,” Journal of Ethnobiology and Ethnomedicine, vol. 6, article no. 8, 2010. View at: Publisher Site | Google Scholar
  33. R. M. Polhill, “Papilionoideae,” in Advances in Legume Systematics I, R. M. Polhill and P. H. Raven, Eds., pp. 191–208, Royal Botanic Gardens, Kew, 1981. View at: Google Scholar
  34. G. Lewis, B. Schrire, B. MacKinder, and M. Lock, Eds., Legumes of the World, Royal Botanical Gardens, Kew, UK, 2005.
  35. M. A. C. Pilla, M. C. D. M. Amorozo, and A. Furlan, “Acquisition and use of medicinal plants in Martim Francisco district, Mogi Mirim Municipality, São Paulo State, Brazil,” Acta Botanica Brasilica, vol. 20, no. 4, pp. 789–802, 2006. View at: Publisher Site | Google Scholar
  36. U. P. Albuquerque et al., “Evaluating two quantitative ethnobotanical Techniques,” Ethnobotany Research and Applications, vol. 4, pp. 051–060, 2006. View at: Google Scholar
  37. S. Akerreta, R. Y. Cavero, V. López, and M. I. Calvo, “Analyzing factors that influence the folk use and phytonomy of 18 medicinal plants in Navarra,” Journal of Ethnobiology and Ethnomedicine, vol. 3, article no. 16, 2007. View at: Publisher Site | Google Scholar
  38. M. L. De Mesquita, J. Desrivot, C. Bories et al., “Antileishmanial and trypanocidal activity of Brazilian Cerrado plants,” Memorias do Instituto Oswaldo Cruz, vol. 100, no. 7, pp. 783–787, 2005. View at: Google Scholar
  39. G. T. Tan, S. Lee, I. S. Lee et al., “Natural-product inhibitors of human DNA ligase I,” Biochemical Journal, vol. 314, no. 3, pp. 993–1000, 1996. View at: Google Scholar
  40. A. J. Vlietinck, T. De Bruyne, S. Apers, and L. A. Pieters, “Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection,” Planta Medica, vol. 64, no. 2, pp. 97–109, 1998. View at: Google Scholar
  41. B. H. Ali, N. Al Wabel, and G. Blunden, “Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review,” Phytotherapy Research, vol. 19, no. 5, pp. 369–375, 2005. View at: Publisher Site | Google Scholar
  42. V. Hirunpanich, A. Utaipat, N. P. Morales et al., “Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa Linn. (roselle) in vitro using rat low-density lipoprotein (LDL),” Biological and Pharmaceutical Bulletin, vol. 28, no. 3, pp. 481–484, 2005. View at: Publisher Site | Google Scholar
  43. O. Carvajal-Zarrabal, S. M. Waliszewski, D. M. Barradas-Dermitz et al., “The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats,” Plant Foods for Human Nutrition, vol. 60, no. 4, pp. 153–159, 2005. View at: Publisher Site | Google Scholar
  44. R. S. Crawford, E. A. Kirk, M. E. Rosenfeld, R. C. LeBoeuf, and A. Chait, “Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, no. 9, pp. 1506–1513, 1998. View at: Google Scholar
  45. E. B. Rimm and M. J. Stampfer, “Antioxidants for vascular disease,” Medical Clinics of North America, vol. 84, no. 1, pp. 239–249, 2000. View at: Google Scholar
  46. D. X. Hou, X. Tong, N. Terahara, D. Luo, and M. Fujii, “Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway,” Archives of Biochemistry and Biophysics, vol. 440, no. 1, pp. 101–109, 2005. View at: Publisher Site | Google Scholar
  47. F. B. O. Mojiminiyi, M. Dikko, B. Y. Muhammad et al., “Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa,” Fitoterapia, vol. 78, no. 4, pp. 292–297, 2007. View at: Publisher Site | Google Scholar
  48. M. Haji Faraji and A. H. Haji Tarkhani, “The effect of sour tea (Hibiscus sabdariffa) on essential hypertension,” Journal of Ethnopharmacology, vol. 65, no. 3, pp. 231–236, 1999. View at: Publisher Site | Google Scholar
  49. A. Herrera-Arellano, S. Flores-Romero, M. A. Chávez-Soto, and J. Tortoriello, “Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial,” Phytomedicine, vol. 11, no. 5, pp. 375–382, 2004. View at: Publisher Site | Google Scholar
  50. M. Sarr, S. Ngom, M. O. Kane et al., “In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta,” Nutrition and Metabolism, vol. 6, article no. 45, 2009. View at: Publisher Site | Google Scholar
  51. V. Prasongwatana, S. Woottisin, P. Sriboonlue, and V. Kukongviriyapan, “Uricosuric effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former subjects,” Journal of Ethnopharmacology, vol. 117, no. 3, pp. 491–495, 2008. View at: Publisher Site | Google Scholar
  52. A. A. Dafallah and Z. Al-Mustafa, “Investigation of the anti-inflammatory activity of acacia nilotica and hibiscus sabdariffa,” American Journal of Chinese Medicine, vol. 24, no. 3-4, pp. 263–269, 1996. View at: Google Scholar
  53. Beltran-Debon et al., “The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocytechemo attractant protein-1 in humans,” Phytomedicine, vol. 17, pp. 186–191, 2010. View at: Google Scholar
  54. E.-S. Kao, J.-D. Hsu, C.-J. Wang, S.-H. Yang, S.-Y. Cheng, and H.-J. Lee, “Polyphenols extracted from hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditions and regulating cyclooxygenase-2 expression,” Bioscience, Biotechnology and Biochemistry, vol. 73, no. 2, pp. 385–390, 2009. View at: Publisher Site | Google Scholar
  55. O. Carvajal-Zarrabal, P. M. Hayward-Jones, Z. Orta-Flores et al., “Effect of hibiscus sabdariffa L. dried calyx ethanol extract on fat absorption-excretion, and body weight implication in rats,” Journal of Biomedicine and Biotechnology, vol. 2009, Article ID 394592, 5 pages, 2009. View at: Publisher Site | Google Scholar
  56. B. H. Ali, H. M. Mousa, and S. El-Mougy, “The effect of a water extract and anthocyanins of Hibiscus sabdariffa L. on paracetamol-induced hepatoxicity in rats,” Phytotherapy Research, vol. 17, no. 1, pp. 56–59, 2003. View at: Publisher Site | Google Scholar
  57. T. H. Tseng, E. S. Kao, C. Y. Chu, F. P. Chou, H. W. Lin Wu, and C. J. Wang, “Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes,” Food and Chemical Toxicology, vol. 35, no. 12, pp. 1159–1164, 1997. View at: Publisher Site | Google Scholar
  58. J. Y. Liu, C. C. Chen, W. H. Wang, J. D. Hsu, M. Y. Yang, and C. J. Wang, “The protective effects of Hibiscus sabdariffa extract on CCl 4-induced liver fibrosis in rats,” Food and Chemical Toxicology, vol. 44, no. 3, pp. 336–343, 2006. View at: Publisher Site | Google Scholar
  59. Y. C. Chang, H. P. Huang, J. D. Hsu, S. F. Yang, and C. J. Wang, “Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells,” Toxicology and Applied Pharmacology, vol. 205, no. 3, pp. 201–212, 2005. View at: Publisher Site | Google Scholar
  60. H. H. Lin, J. H. Chen, W. H. Kuo, and C. J. Wang, “Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation,” Chemico-Biological Interactions, vol. 165, no. 1, pp. 59–75, 2007. View at: Publisher Site | Google Scholar
  61. E. O. Farombi and A. Fakoya, “Free radical scavenging and antigenotoxic activities of natural phenolic compounds in dried flowers of Hibiscus sabdariffa L,” Molecular Nutrition and Food Research, vol. 49, no. 12, pp. 1120–1128, 2005. View at: Publisher Site | Google Scholar
  62. T. O. Fakeye, A. Pal, D. U. Bawankule, and S. P. S. Khanuja, “Immunomodulatory effect of extracts of Hibiscus sabdariffa L. (family malvaceae) in a mouse model,” Phytotherapy Research, vol. 22, no. 5, pp. 664–668, 2008. View at: Publisher Site | Google Scholar
  63. M. Y. Yang, C. H. Peng, K. C. Chan, Y. I. S. Yang, C. N. Huang, and C. J. Wang, “The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance,” Journal of Agricultural and Food Chemistry, vol. 58, no. 2, pp. 850–859, 2010. View at: Publisher Site | Google Scholar
  64. C. N. Huang, K. C. Chan, W. T. Lin, S. L. Su, C. J. Wang, and C. H. Peng, “Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucoses-A mechanism involves connective tissue growth factor signals,” Journal of Agricultural and Food Chemistry, vol. 57, no. 8, pp. 3073–3079, 2009. View at: Publisher Site | Google Scholar
  65. R. Mohamed, J. Fernández, M. Pineda, and M. Aguilar, “Roselle (Hibiscus sabdariffa) seed oil is a rich source of γ-tocopherol,” Journal of Food Science, vol. 72, no. 3, pp. S207–S211, 2007. View at: Publisher Site | Google Scholar
  66. H. F. Lorenzi and F. J. A. Matos, Plantas Medicinais do Brasil, nativas e exóticas, Plantarum, São Paulo, Brazil, 1st edition, 2008.
  67. H. Lorenzi, Plantas medicinais no Brasil: nativas e exóticas cultivadas, Instituto Plantarum, Nova Odessa, Brazil, 2000.
  68. A. D. Corrêa, R. Siqueira-Batista, and L. E. M. Quintas, Plantas Medicinais – do Cultivo à Terapêutica-Rio de Janeiro, Editora Vozes, 1998.
  69. F. J. A. Matos, Plantas da medicina popular do Nordeste. Fortaleza, Edições UFC, 1999.
  70. L. Tiansheng, M. A. Menelaou, D. Vargas, F. R. Fronczek, and N. H. Fischer, “Polyacetylenes and diterpenes from Solidago canadensis Phytochemistry,” The International Journal of Plant Biochemistry, vol. 32, no. 6, pp. 1483–1488, 1993. View at: Google Scholar
  71. G. Reznicek, J. Jurenitsch, M. Plasun et al., “Four major saponins from Solidago canadensis,” Phytochemistry, vol. 30, no. 5, pp. 1629–1633, 1991. View at: Google Scholar
  72. G. Reznicek, J. Jurenitsch, G. Michl, and E. Haslinger, “The first structurally confirmed saponin from solidago gigantea: structure elucidation by modern NMR techniques,” Tetrahedron Letters, vol. 30, no. 31, pp. 4097–4100, 1989. View at: Google Scholar
  73. M. A. F. Neto, D. J. Fagundes, M. E. Beletti, N. F. Novo, Y. Juliano, and N. Penha-Silva, “Systemic use of Solidago microglossa DC in the cicatrization of open cutaneous wounds in rats,” Brazilian Journal of Morphological Sciences, vol. 21, pp. 204–210, 2004. View at: Google Scholar
  74. A. F. Morel, G. O. Dias, C. Porto, E. Simionatto, C. Z. Stuker, and I. I. Dalcol, “Antimicrobial activity of extractives of Solidago microglossa,” Fitoterapia, vol. 77, no. 6, pp. 453–455, 2006. View at: Publisher Site | Google Scholar
  75. H. Hoste, F. Jackson, S. Athanasiadou, S. M. Thamsborg, and S. O. Hoskin, “The effects of tannin-rich plants on parasitic nematodes in ruminants,” Trends in Parasitology, vol. 22, no. 6, pp. 253–261, 2006. View at: Publisher Site | Google Scholar
  76. T. Yokozawa, T. Nakagawa, K. I. Lee, E. J. Cho, K. Terasawa, and S. Takeuchi, “Effects of green tea tannin on cisplatin-induced nephropathy in LLC-PK1 cells and rats,” Journal of Pharmacy and Pharmacology, vol. 51, no. 11, pp. 1325–1331, 1999. View at: Google Scholar
  77. D. Grassi, G. Desideri, G. Croce, S. Tiberti, A. Aggio, and C. Ferri, “Flavonoids, vascular function and cardiovascular protection,” Current Pharmaceutical Design, vol. 15, no. 10, pp. 1072–1084, 2009. View at: Publisher Site | Google Scholar
  78. Y. Huang, X. Q. Yao, S. Y. Tsang, C. W. Lau, and Z. Y. Chen, “Role of endothelium/nitric oxide in vascular response, to flavonoids and epicatechin,” Acta Pharmacologica Sinica, vol. 21, no. 12, pp. 1119–1124, 2000. View at: Google Scholar
  79. C. O. Van Den Broucke and J. A. Lemli, “Spasmolytic activity of the flavonoids from Thymus vulgaris,” Pharmaceutisch Weekblad - Scientific Edition, vol. 5, no. 1, pp. 9–14, 1983. View at: Google Scholar
  80. K. G. Kissmam and D. Groth, Plantas infestantes e nocivas, vol. 2, BASF, São Paulo, Brazil, 2nd edition, 1999.
  81. F. V. Santos, I. M. S. Colus, M. A. Silva, W. Vilegas, and E. A. Varanda, “Assessment of DNA damage by extracts and fractions of Strychnos pseudoquina, a Brazilian medicinal plant with antiulcerogenic activity,” Food and Chemical Toxicology, vol. 44, no. 9, pp. 1585–1589, 2006. View at: Publisher Site | Google Scholar
  82. M. D. Bagatini, J. M. Fachinetto, A. C. F. Da Silva, and S. B. Tedesco, “Cytotoxic effects of infusions (tea) of Solidago microglossa DC. (Asteraceae) on the cell cycle of Allium cepa,” Brazilian Journal of Pharmacognosy, vol. 19, no. 2B, pp. 632–636, 2009. View at: Google Scholar
  83. D. Boulanger, E. Brouillette, F. Jaspar et al., “Helenalin reduces Staphylococcus aureus infection in vitro and in vivo,” Veterinary Microbiology, vol. 119, no. 2–4, pp. 330–338, 2007. View at: Publisher Site | Google Scholar
  84. V. F. Andrade-Neto, M. G. L. Brandão, J. R. Stehmann, L. A. Oliveira, and A. U. Krettli, “Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil,” Journal of Ethnopharmacology, vol. 87, no. 2-3, pp. 253–256, 2003. View at: Publisher Site | Google Scholar
  85. M. Nicoletti, M. O. F. Goulart, R. A. De Lima, A. E. Goulart, F. Delle Monache, and G. B. M. Bettolo, “Flavonoids and alkaloids from Strychnos pseudoquina,” Journal of Natural Products, vol. 47, no. 6, pp. 953–957, 1984. View at: Google Scholar
  86. M. Aparecido Da Silva, B. P. Murino Rafacho, C. A. Hiruma-Lima et al., “Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice,” Chemical and Pharmaceutical Bulletin, vol. 53, no. 8, pp. 881–885, 2005. View at: Publisher Site | Google Scholar
  87. A. C. Honorio-Franca, C. M. Marins, F. Boldrini, and E. L. Franca, “Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL),” Acta Cirurgica Brasileira, vol. 23, pp. 504–510, 2008. View at: Google Scholar
  88. C. M. Nishijima, C. M. Rodrigues, M. A. Silva, M. Lopes-Ferreira, W. Vilegas, and C. A. Hiruma-Lima, “Anti-hemorrhagic activity of four brazilian vegetable species against Bothrops jararaca venom,” Molecules, vol. 14, no. 3, pp. 1072–1080, 2009. View at: Publisher Site | Google Scholar
  89. I. B. Noll, Isolamento, identificação e doseamento de furanocumarinas, M.S. thesis, Universidade Federal do Rio Grande do Sul, Porto Alegre, 1984.
  90. C. M. O. Simões et al., Plantas da medicina popular do Rio Grande do Sul, Editora da Universidade, Porto Alegre, 1996.
  91. T. Uchiyama, S. Hara, M. Makino, and Y. Fujimoto, “seco-adianane-type triterpenoids from Dorstenia brasiliensis (moraceae),” Phytochemistry, vol. 60, no. 8, pp. 761–764, 2002. View at: Publisher Site | Google Scholar
  92. C. A. L. Cardoso, W. Vilegas, A. Barison, and N. K. Honda, “Simultaneous determination of furanocoumarins in infusions and decoctions from "Carapiá" (Dorstenia species) by high-performance liquid chromatography,” Journal of Agricultural and Food Chemistry, vol. 50, no. 6, pp. 1465–1469, 2002. View at: Publisher Site | Google Scholar
  93. N. O. A. Omisore, C. O. Adewunmi, E. O. Iwalewa et al., “Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 7, pp. 1087–1094, 2005. View at: Google Scholar
  94. C. M. Garcia, Estudo fitoquímico e atividade biológica de Pavonia distinguenda A.ST.- HILL. et NAUDIN E Dorstenia brasiliensis LAM, Ph.D. thesis, Universidade Federal de Santa Maria - RS, 2007.
  95. B. M. Ruppelt, E. F. Pereira, L. C. Gonçalves, and N. A. Pereira, “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities,” Memorias do Instituto Oswaldo Cruz, vol. 86, pp. 203–205, 1991. View at: Google Scholar
  96. B. M. Abegaz, B. T. Ngadjui, E. Dongo, B. Ngameni, M. N. Nindi, and M. Bezabih, “Chalcones and other constituents of Dorstenia prorepens and Dorstenia zenkeri,” Phytochemistry, vol. 59, no. 8, pp. 877–883, 2002. View at: Publisher Site | Google Scholar
  97. J. H. Y. Vilegas, F. M. Lanças, W. Vilegas, and G. L. Pozetti, “Further triterpenes, steroids and furocoumarins from Brazilian medicinal plants of Dorstenia genus (Moraceae),” Journal of the Brazilian Chemical Society, vol. 8, no. 5, pp. 529–535, 1997. View at: Google Scholar
  98. M. De Fátima Agra, P. F. De Freitas, and J. M. Barbosa-Filho, “Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil,” Brazilian Journal of Pharmacognosy, vol. 17, no. 1, pp. 114–140, 2007. View at: Google Scholar
  99. L. Balestrin, J. F. Gaspari Dias, O. G. Miguel, D. S. G. Dall'Stella, and M. D. Miguel, “Contribution to the phytochemical study of Dorstenia multiformis Miquel (Moraceae) with approach in antioxidant activity,” Brazilian Journal of Pharmacognosy, vol. 18, no. 2, pp. 230–235, 2008. View at: Google Scholar
  100. M. M. Iwu, J. E. Jackson, J. D. Tally, and D. L. Klayman, “Evaluation of plant extracts for antileishmanial activity using a mechanism-based radiorespirometric microtechnique (RAM),” Planta Medica, vol. 58, no. 5, pp. 436–441, 1992. View at: Publisher Site | Google Scholar
  101. M. Kawasaki, T. Hayashi, M. Arisawa et al., “Structure of scoparic acid A, a new labdane-type diterpenoid from A Paraguayan crude drug 'Typycha Kuratu' (Scoparia Dulcis L.),” Chemical and Pharmaceutical Bulletin, vol. 35, no. 9, pp. 3963–3966, 1987. View at: Google Scholar
  102. M. Ahsan, S. K. N. Islam, A. I. Gray, and W. H. Stimson, “Cytotoxic diterpenes from Scoparia dulcis,” Journal of Natural Products, vol. 66, no. 7, pp. 958–961, 2003. View at: Publisher Site | Google Scholar
  103. Y. Li, X. Chen, M. Satake, Y. Oshima, and Y. Ohizumi, “Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis,” Journal of Natural Products, vol. 67, no. 4, pp. 725–727, 2004. View at: Publisher Site | Google Scholar
  104. H. Nishino, T. Hayashi, M. Arisawa, Y. Satomi, and A. Iwashima, “Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L,” Oncology, vol. 50, no. 2, pp. 100–103, 1993. View at: Google Scholar
  105. T. Hayashi, K. Okamura, M. Kakemi et al., “Scopadulcic acid B, a new tetracyclic diterpenoid from Scoparia dulcis L. Its structure, H+,K+-adenosine triphosphatase inhibitory activity and pharmacokinetic behaviour in rats,” Chemical and Pharmaceutical Bulletin, vol. 38, no. 10, pp. 2740–2745, 1990. View at: Google Scholar
  106. K. Hayashi, S. Niwayama, T. Hayashi, R. Nago, H. Ochiai, and N. Morita, “In vitro and in vivo antiviral activity of scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against herpes simplex virus type 1,” Antiviral Research, vol. 9, no. 6, pp. 345–354, 1988. View at: Publisher Site | Google Scholar
  107. S. M. Freire, L. M. Torres, N. F. Roque, C. Souccar, and A. J. Lapa, “Analgesic activity of a triterpene isolated from Scoparia dulcis L. (Vassourinha),” Memorias do Instituto Oswaldo Cruz, vol. 86, pp. 149–151, 1991. View at: Google Scholar
  108. Y. Li and Y. Ohizumi, “Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of Paraguay and Thailand,” Yakugaku Zasshi, vol. 124, no. 7, pp. 417–424, 2004. View at: Publisher Site | Google Scholar
  109. M. Ahmed, H. A. Shikha, S. K. Sadhu, M. T. Rahman, and B. K. Datta, “Analgesic, diuretic, and anti-inflammatory principle from Scoparia dulcis,” Pharmazie, vol. 56, no. 8, pp. 657–660, 2001. View at: Google Scholar
  110. M. Babincová and P. Sourivong, “Free radical scavenging activity of Scoparia dulcis extract,” Journal of Medicinal Food, vol. 4, no. 3, pp. 179–181, 2001. View at: Google Scholar
  111. T. K. Praveen, S. Dharmaraj, J. Bajaj et al., “Hepatoprotective activity of petroleum ether, diethyl ether, and methanol extract of Scoparia dulcis L. against CCl4-induced acute liver injury in mice,” Indian Journal of Pharmacology, vol. 41, no. 3, pp. 110–114, 2009. View at: Publisher Site | Google Scholar
  112. W. D. Ratnasooriya, J. R. A. C. Jayakody, G. A. S. Premakumara, and E. R. H. S. S. Ediriweera, “Antioxidant activity of water extract of Scoparia dulcis,” Fitoterapia, vol. 76, no. 2, pp. 220–222, 2005. View at: Publisher Site | Google Scholar
  113. J. C. Tsai, W. H. Peng, T. H. Chiu et al., “Hepatoprotective effect of scoparia dulcis on carbon tetrachloride induced acute liver injury in mice,” American Journal of Chinese Medicine, vol. 38, no. 4, pp. 761–775, 2010. View at: Publisher Site | Google Scholar
  114. M. Latha, K. M. Ramkumar, L. Pari, P. N. Damodaran, V. Rajeshkannan, and T. Suresh, “Phytochemical and antimicrobial study of an antidiabetic plant: Scoparia dulcis L,” Journal of Medicinal Food, vol. 9, no. 3, pp. 391–394, 2006. View at: Publisher Site | Google Scholar
  115. M. G. Phan, T. S. Phan, K. Matsunami, and H. Otsuka, “Chemical and biological evaluation on scopadulane-type diterpenoids from Scoparia dulcis of Vietnamese origin,” Chemical and Pharmaceutical Bulletin, vol. 54, no. 4, pp. 546–549, 2006. View at: Publisher Site | Google Scholar
  116. M. S. Gachet, J. S. Lecaro, M. Kaiser et al., “Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis,” Journal of Ethnopharmacology, vol. 128, no. 1, pp. 184–197, 2010. View at: Publisher Site | Google Scholar
  117. M. Babincová, K. Schronerová, and P. Sourivong, “Antiulcer activity of water extract of Scoparia dulcis,” Fitoterapia, vol. 79, no. 7-8, pp. 587–588, 2008. View at: Publisher Site | Google Scholar
  118. S. Mesía-Vela, M. Bielavsky, L. M. B. Torres et al., “In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 403–408, 2007. View at: Publisher Site | Google Scholar
  119. L. Pari and S. Venkateswaran, “Hypoglycaemic activity of Scopariadulcis L. extract in alloxan induced hyperglycaemic rats,” Phytotherapy Research, vol. 16, pp. 662–664, 2002. View at: Google Scholar
  120. J. E. Beh, J. Latip, M. P. Abdullah, A. Ismail, and M. Hamid, “Scoparia dulcis (SDF7) endowed with glucose uptake properties on L6 myotubes compared insulin,” Journal of Ethnopharmacology, vol. 129, no. 1, pp. 23–33, 2010. View at: Publisher Site | Google Scholar
  121. L. Pari, M. Latha, and C. A. Rao, “Effect of Scoparia dulcis extract on insulin receptors in streptozotocin induced diabetic rats: Studies on insulin binding to erythrocytes,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 15, no. 3-4, pp. 223–240, 2004. View at: Google Scholar
  122. H. Lorenzi, Árvores brasileiras: Manual de identificação e cultivo de plantas arbóreas nativas do Brasil, vol. 1, Plantarum, Nova Odessa, Brazil, 2nd edition, 1998.
  123. J. C. A. Tanaka, C. C. Da Silva, B. P. Dias Filho, C. V. Nakamura, J. E. De Carvalho, and M. A. Foglio, “Chemical constituents of Luehea divaricata Mart. (Tiliaceae),” Quimica Nova, vol. 28, no. 5, pp. 834–837, 2005. View at: Google Scholar
  124. G. M. Barroso, Sistemática de angiospermas do Brasil, vol. 1, EDUSP, São Paulo, Brazil, 1978.
  125. H. J. Choi, J. S. Eun, B. G. Kim, S. Y. Kim, H. Jeon, and Y. Soh, “Vitexin, an HIF-1α inhibitor, has anti-metastatic potential in PC12 cells,” Molecules and Cells, vol. 22, no. 3, pp. 291–299, 2006. View at: Google Scholar
  126. J. H. Kim, B. C. Lee, J. H. Kim et al., “The isolation and antioxidative effects of vitexin from Acer palmatum,” Archives of Pharmacal Research, vol. 28, no. 2, pp. 195–202, 2005. View at: Publisher Site | Google Scholar
  127. Y. W. Hsum, W. T. Yew, P. L. V. Hong et al., “Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-KB and AP-1 activation in raji cells,” Planta Medica, vol. 77, no. 2, pp. 152–157, 2011. View at: Publisher Site | Google Scholar
  128. C. Li, Z. Yang, C. Zhai et al., “Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway,” Molecular Cancer, vol. 9, article no. 73, 2010. View at: Publisher Site | Google Scholar
  129. J. B. Müller, C. S. Ceron, V. T. Kuntz, and P. Pozzatti, “Avaliação da Suscetibilidade Antifúngica e Antibacteriana do Extrato Bruto e Frações das Folhas de Luehea divaricata Martius,” in Anais da 58ª Reunião Anual da SBPC, Florianópolis, Brazil, 2006. View at: Google Scholar
  130. A. E. Bighetti, M. A. Antônio, A. Possent, M. A. Foglio, M. G. Siqueira, and J. E. Carvalho, “Efeitos da administração aguda e subcrônica da Luehea divaricata Martus et Zuccarini,” Lecta, vol. 22, no. 1/2, pp. 53–58, 2004. View at: Google Scholar
  131. L. P. Felício, E. M. Silva, V. Ribeiro et al., “Mutagenic potential and modulatory effects of the medicinal plant Luehea divaricata (Malvaceae) in somatic cells of Drosophila melanogaster: SMART/wing,” Genetics and Molecular Research, vol. 10, no. 1, pp. 16–24, 2011. View at: Publisher Site | Google Scholar
  132. S. Zacchino, C. Santecchia, S. Lopez et al., “In vitro antifungal evaluation and studies on mode of action of eight selected species from the Argentina flora,” Phytomedicine, vol. 5, pp. 389–395, 1998. View at: Google Scholar
  133. R. C. Mendonça, J. M. Felfili, B. M. T. Walter et al., “Flora vascular do cerrado,” in Cerrado: ambiente e flora, S. M. Sano and S. P. Almeida, Eds., pp. 289–556, Planaltina, 1998. View at: Google Scholar
  134. S. Solon, L. Lopes, P. T. Sousa-Júnior, and G. Schmeda-Hirschmann, “Free radical scavening activity of Lafoensia pacari,” Journal of Ethnopharmacology, vol. 72, pp. 173–178, 2000. View at: Google Scholar
  135. A. P. Rogerio, C. Fontanari, M. C. C. Melo et al., “Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid,” Journal of Pharmacy and Pharmacology, vol. 58, no. 9, pp. 1265–1273, 2006. View at: Publisher Site | Google Scholar
  136. A. P. Rogerio, C. Fontanari, É. Borducchi et al., “Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma,” European Journal of Pharmacology, vol. 580, no. 1-2, pp. 262–270, 2008. View at: Publisher Site | Google Scholar
  137. M. P. Porto et al., “Avaliação tóxico-genética do extrato de Lafoensia pacari em células somáticas de Drosophila melanogaste,” in Resumos do 54 Congresso Brasileiro de Genética,, 2008. View at: Google Scholar
  138. S. Murakami, Y. Isobe, H. Higima, H. Nagai, M. Muramatu, and S. Otomo, “Inibition of gastric H+K+ ATPase and acid secretion by ellagic acid,” Planta Medica, vol. 57, no. 4, pp. 305–308, 1991. View at: Google Scholar
  139. P. I. Akubue and S. J. Stohs, “Endrin-induced production of nitric oxide by rat peritoneal macrophages,” Toxicology Letters, vol. 62, no. 2-3, pp. 311–316, 1992. View at: Publisher Site | Google Scholar
  140. L. Ramanathan and N. P. Das, “Inhibitory effects of some natural products on metal-induced lipid oxidation in cooked fish,” Biological Trace Element Research, vol. 34, no. 1, pp. 35–44, 1992. View at: Google Scholar
  141. N. T. Sartori and D. T. O. Martins, “Screening’ farmacológico de plantas popularmente utilizadas como antiúlceras em Mato Gross,” in Simpósio de plantas medicinais do Brasil, p. 105, Florianópolis, bRAZIL, 1996. View at: Google Scholar
  142. P. Tamashiro Filho, Avaliação da atividade antiúlcera do extrato bruto metanólico de Lafoensia pacari St. Hil. (mangava brava), M.S. thesis, Universidade Federal de Mato Grosso, Cuiabá, Brazil, 1999.
  143. A. M. S. S. Beserra, Avaliação da atividade gastroprotetora do ácido elágico em modelos animais, M.S. thesis, Universidade Federal de Mato Grosso, Cuiabá, Brazil, 2008.
  144. V. Da Mota Menezes, A. N. Atallah, A. J. Lapa, and W. R. Catapani, “Assessing the therapeutic use of Lafoensia pacari St. Hil. extract (Mangava-Brava) in the eradication of Helicobacter pylori: double-blind randomized clinical trial,” Helicobacter, vol. 11, no. 3, pp. 188–195, 2006. View at: Publisher Site | Google Scholar
  145. V. M. Tonello, Estrutura de populações de Lafoensia pacari St. Hil. e dados etnobotânicos e fenológicos em Nossa Senhora do Livramento, Mato Grosso, M.S. thesis, Universidade Federal de Mato Grosso, Cuiabá, Brazil, 1997.
  146. D. A. Albuquerque and L. Lopes, “Modulation of Delayed-Type Hypersensitivity by Lafoensia pacari St. Hil.,” Bollettino Chimico Farmaceutico, vol. 2, no. 138, p. 120, 1999. View at: Google Scholar
  147. A. P. Rogério, Estudo da atividade antiinflamatória do extrato etanólico de Lafoensia pacari Jaume St. Hilaire (Lythraceae), M.S. thesis, Universidade de São Paulo, Ribeirão Preto, Brazil, 2002.
  148. A. P. Rogerio, A. Sá-Nunes, and L. H. Faccioli, “The activity of medicinal plants and secondary metabolites on eosinophilic inflammation,” Pharmacological Research, vol. 62, no. 4, pp. 298–307, 2010. View at: Publisher Site | Google Scholar
  149. M. V. M. Nascimento, P. M. Galdino, I. F. Florentino et al., “Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid,” Journal of Natural Medicines, vol. 65, no. 3-4, pp. 448–454, 2011. View at: Publisher Site | Google Scholar
  150. I. F. Silva Junior et al., “Avaliação da atividade antifúngica e modo de ação dos extratos da entrecasca, frações e ácido elágico de Lafoensia pacari A. St.-Hil., Lythraceae,” Revista Brasileira de Farmacognosia, vol. 20, no. 3, pp. 422–428, 2010. View at: Publisher Site | Google Scholar
  151. S.-C. F. A. Silva, “Loção para tratamento capilar e respectivo processo de preparação,” Nº do Pedido: PI9903518-9 A2. Classiicação A61K 7/06. Instituto Nacional de Propriedade Industrial, 1996. View at: Google Scholar

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