Clerodendrum inerme Leaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia
Figure 4
CI extract prevented PPI disruptions induced by NMDA channel blockers in mice. Effects of CI extract on PPI disruptions induced by NMDA channel blockers, ketamine (a) and MK-801(b). Mice were pretreated with CI extract (100 mg/kg, i.p.) or vehicle for 15 min, followed by ketamine (30 mg/kg, i.p.) for 10 min (a) or MK-801 (0.3 mg/kg, i.p.) for 20 min (b). The control group is the mice treated with normal saline alone (without NMDA blockers). The saline group is the mice pretreated with normal saline before being challenged with ketamine or MK-801. *P < 0.05, **P < 0.01, and ***P < 0.001 versus the control group; ##P < 0.01 and ###P < 0.001 versus the vehicle group with the same acoustic stimulation protocol (Student’s t test). N = 8.
