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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 284301, 8 pages
http://dx.doi.org/10.1155/2012/284301
Research Article

Clerodendrum inerme Leaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia

1Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan
2Department of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan
3Graduate Institute of Pharmacognosy, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan
4Department of Pediatrics, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan
5Department of Pediatrics, Taipei City Hospital, Zhongxiao Branch, No. 87, Tongde Road, Taipei 115, Taiwan
6Medical and Pharmaceutical Industry Technology and Development Center, 7F, No. 9, Wuquan Road, Wugu Dist., New Taipei 248, Taiwan
7Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan

Received 23 February 2012; Accepted 1 June 2012

Academic Editor: Ching Liang Hsieh

Copyright © 2012 Hon-Lie Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. C. Fan, W. J. Huang, and L. C. Chiou, “Intractable chronic motor tics dramatically respond to Clerodendrum inerme (L) gaertn,” Journal of Child Neurology, vol. 24, no. 7, pp. 887–890, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. M. Robertson, “Diagnosing Tourette syndrome is it a common disorder?” Journal of Psychosomatic Research, vol. 55, no. 1, pp. 3–6, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. H. S. Wang and M. F. Kuo, “Tourette's syndrome in Taiwan: an epidemiological study of tic disorders in an elementary school at Taipei County,” Brain and Development, vol. 25, supplement 1, pp. S29–S31, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. H. S. Singer, “Tourette's syndrome: from behaviour to biology,” The Lancet Neurology, vol. 4, no. 3, pp. 149–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Kurlan, D. Whitmore, C. Irvine, M. P. McDermott, and P. G. Como, “Tourette's syndrome in a special education population: a pilot study involving a single school district,” Neurology, vol. 44, no. 4, pp. 699–702, 1994. View at Google Scholar · View at Scopus
  6. H. S. Singer, “Discussing outcome in tourette syndrome,” Archives of Pediatrics and Adolescent Medicine, vol. 160, no. 1, pp. 103–105, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. H. S. Singer and K. Minzer, “Neurobiology of Tourette's syndrome: concepts of neuroanatomic localization and neurochemical abnormalities,” Brain and Development, vol. 25, supplement 1, pp. S70–S84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. J. F. Leckman, D. E. Walker, and D. J. Cohen, “Premonitory urges in Tourette's syndrome,” American Journal of Psychiatry, vol. 150, no. 1, pp. 98–102, 1993. View at Google Scholar · View at Scopus
  9. N. R. Swerdlow, B. Karban, Y. Ploum, R. Sharp, M. A. Geyer, and A. Eastvold, “Tactile prepuff inhibition of startle in children with Tourette's syndrome: in search of an “fMRI-friendly” startle paradigm,” Biological Psychiatry, vol. 50, no. 8, pp. 578–585, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. N. R. Swerdlow, M. A. Geyer, and D. L. Braff, “Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges,” Psychopharmacology, vol. 156, no. 2-3, pp. 194–215, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. F. X. Castellanos, E. J. Fine, D. Kaysen, W. L. Marsh, J. L. Rapoport, and M. Hallett, “Sensorimotor gating in boys with Tourette's syndrome and ADHD: preliminary results,” Biological Psychiatry, vol. 39, no. 1, pp. 33–41, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. E. M. Ornitz, G. L. Hanna, and J. de Traversay, “Prestimulation-induced startle modulation in attention-deficit hyperactivity disorder and nocturnal enuresis,” Psychophysiology, vol. 29, no. 4, pp. 437–451, 1992. View at Google Scholar · View at Scopus
  13. K. Hoenig, A. Hochrein, B. B. Quednow, W. Maier, and M. Wagner, “Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder,” Biological Psychiatry, vol. 57, no. 10, pp. 1153–1158, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Braff, C. Stone, E. Callaway, M. Geyer, I. Glick, and L. Bali, “Prestimulus effects on human startle reflex in normals and schizophrenics,” Psychophysiology, vol. 15, no. 4, pp. 339–343, 1978. View at Google Scholar · View at Scopus
  15. J. Kerbeshian, C. Z. Peng, and L. Burd, “Tourette syndrome and comorbid early-onset schizophrenia,” Journal of Psychosomatic Research, vol. 67, no. 6, pp. 515–523, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. A. Geyer and B. Moghaddam, “Animal models relevant to schizophrenia disorders,” in Neuropsychopharmacology: The Fifth Generation of Progress, K. L. Davis, D. Charney, J. T. Coyle, and C. Nemeroff, Eds., pp. 689–701, American College of Neuropsychopharmacology, 2002. View at Google Scholar
  17. D. C. Javitt and S. R. Zukin, “Recent advances in the phencyclidine model of schizophrenia,” American Journal of Psychiatry, vol. 148, no. 10, pp. 1301–1308, 1991. View at Google Scholar · View at Scopus
  18. R. S. Mansbach, M. A. Geyer, and D. L. Braff, “Dopaminergic stimulation disrupts sensorimotor gating in the rat,” Psychopharmacology, vol. 94, no. 4, pp. 507–514, 1988. View at Google Scholar · View at Scopus
  19. R. S. Mansbach and M. A. Geyer, “Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat,” Neuropsychopharmacology, vol. 2, no. 4, pp. 299–308, 1989. View at Publisher · View at Google Scholar · View at Scopus
  20. R. S. Mansbach and M. A. Geyer, “Parametric determinants in pre-stimulus modification of acoustic startle: interaction with ketamine,” Psychopharmacology, vol. 105, no. 2, pp. 162–168, 1991. View at Google Scholar · View at Scopus
  21. N. R. Swerdlow, D. L. Braff, M. A. Geyer, and G. F. Koob, “Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics,” Biological Psychiatry, vol. 21, no. 1, pp. 23–33, 1986. View at Google Scholar · View at Scopus
  22. M. A. Geyer, K. Krebs-Thomson, D. L. Braff, and N. R. Swerdlow, “Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review,” Psychopharmacology, vol. 156, no. 2-3, pp. 117–154, 2001. View at Publisher · View at Google Scholar · View at Scopus