Figure 3: Skin temperature was measured in the prevention study after 4 weeks (a) and after 8 weeks (b) of treatment, from mice treated with either HFD (DIO) or L. laricina at 125 or 250 mg/kg, which was incorporated in the HFD for 8 weeks. All values are mean ± SEM. Number of animals/group for prevention protocol DIO = 11; L. laricina 125 = 13; L. laricina 250 = 13. *denotes significantly different as compared to DIO group (one-way ANOVA; post hoc analysis Holm-Sidak or Bonferroni-Dunn test; ).