Research Article

Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia

Table 1

Summary of the biochemical effects in the bicep femoris, DRG, and serum affected by one- and five-dosage dry needling in the biceps femoris with MTrSs.

BiochemicalsImmediately after DN5 days after DN
1D5D1D5D

Biceps femoris
β-endorphin
 Substance P
 TNF-α
 iNOS
 HIF-1α
 COX-2
 VEGF
DRG
 Substance P
Serum
β-endorphin
 TNF-α

indicates the significant increase in dry needling-treated groups compared with their sham groups. indicates reduction of Substance P in 1D group immediately after DN. indicates the significant increase in the 5D group compared with the 1D group. — indicates no significant difference between the dry needling-treated groups and the sham groups. Abbreviations: 1D: one-dosage dry needling; 5D: five-dosage dry needling; COX-2: cyclooxygenase-2; DN: dry needling; DRG: dorsal root ganglion; HIF-1α: hypoxia-inducible factor-1α; iNOS: inducible isoform of nitric oxide synthases; TNF-α: tumor necrosis factor-α; VEGF: vascular endothelial growth factor.