Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 350239, 10 pages
http://dx.doi.org/10.1155/2012/350239
Research Article

Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB

1Department of Obstetrics and Gynecology, Tri-Service General Hospital, No. 325, Section 2, Cheng-Kung Road, Neihu, Taipei 11490, Taiwan
2School of Dentistry, National Defense Medical Center, No. 161, Section 6, Minquan E. Road, Neihu, Taipei 11490, Taiwan
3Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei 11490, Taiwan
4Kang-Ning Junior College of Medical Care and Management, Taipei 11490, Taiwan
5Department of Microbiology and Immunology, National Defense Medical Center, Taipei 11490, Taiwan
6Department of Pharmacology, National Defense Medical Center, Taipei 11490, Taiwan
7Department of Pathology, Da-Chien General Hospital, Miaoli 36052, Taiwan
8Department of Nursing, Jente Junior College of Medicine, Nursing, and Management, Miaoli 35664, Taiwan

Received 29 September 2012; Revised 28 November 2012; Accepted 2 December 2012

Academic Editor: Yoshiyuki Kimura

Copyright © 2012 Chien-Chih Ou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Xiao-Jiaoyang Li, Zhen-Zhou Jiang, and Lu-yong Zhang, “Triptolide: Progress on research in pharmacodynamics and toxicology,” Journal of Ethnopharmacology, vol. 155, no. 1, pp. 67–79, 2014. View at Publisher · View at Google Scholar
  • Shanthi Kanthala, Ted Gauthier, and Seetharama Satyanarayanajois, “Structure-Activity Relationships of Peptidomimetics that Inhibit PPI of HER2-HER3,” Biopolymers, vol. 101, no. 6, pp. 693–702, 2014. View at Publisher · View at Google Scholar
  • Olga Krizanova, Iveta Steliarova, Lucia Csaderova, and Michal Pastorek, “Capsaicin induces apoptosis in PC12 cells through ER stress,” Oncology Reports, vol. 31, no. 2, pp. 581–588, 2014. View at Publisher · View at Google Scholar
  • Cuicui Meng, Hongcheng Zhu, Hongmei Song, Zhongming Wang, Guanhong Huang, Defan Li, Zhaoming Ma, Jianhua Ma, Qin Qin, Xinchen Sun, and Jianxin Ma, “Targets and molecular mechanisms of triptolide in cancer therapy,” Chinese Journal of Cancer Research, vol. 26, no. 5, pp. 622–626, 2014. View at Publisher · View at Google Scholar
  • Swadesh Sarkar, and Santanu Paul, “Triptolide mediated amelioration of breast cancer via modulation of molecular pathways,” Pharmacognosy Journal, vol. 9, no. 6, pp. 838–845, 2014. View at Publisher · View at Google Scholar
  • Haiji Wang, Duanye Ma, Chenghong Wang, Shanna Zhao, and Chengbiao Liu, “Triptolide Inhibits Invasion and Tumorigenesis of Hepatocellular Carcinoma MHCC-97H Cells Through NF-kappa B Signaling,” Medical Science Monitor, vol. 22, pp. 1827–1836, 2016. View at Publisher · View at Google Scholar
  • Qin-Hang Wu, and Shi-Yuan Fu, “Advances in studies on ovarian cancer treated by triptolide,” Chinese Traditional and Herbal Drugs, vol. 47, no. 6, pp. 1049–1052, 2016. View at Publisher · View at Google Scholar
  • Zhongye Wang, Zhenyuan Zhai, and Xiulan Du, “Celastrol inhibits migration and invasion through blocking the NF-κB pathway in ovarian cancer cells,” Experimental and Therapeutic Medicine, vol. 14, no. 1, pp. 819–824, 2017. View at Publisher · View at Google Scholar
  • Ran Li, Zhuo Zhang, Junwen Wang, Yiming Huang, Wei Sun, Ruifan Xie, Feng Hu, and Ting Lei, “Triptolide suppresses growth and hormone secretion in murine pituitary corticotroph tumor cells via NF-kappaB signaling pathway,” Biomedicine & Pharmacotherapy, vol. 95, pp. 771–779, 2017. View at Publisher · View at Google Scholar
  • Cheng-Yu Yang, Chih-Kung Lin, Cheng-Chih Hsieh, Shing-Hwa Huang, Kuo-Hsing Ma, Yi-Shing Shieh, Huey-Kang Sytwu, Gu-Jiun Lin, and Yuan-Wu Chen, “Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells,” Clinical Oral Investigations, vol. 21, no. 1, pp. 419–427, 2017. View at Publisher · View at Google Scholar
  • Guo-Dong Wang, Guang Wan, Jun-Tao Wu, Qiu-Dong Liang, Shen-Peng Liu, Xue-Jun Du, and Lian-Bao Miao, “Triptolide inhibits the function of TNF-α in osteoblast differentiation by inhibiting the NF-κB signaling pathway,” Experimental and Therapeutic Medicine, vol. 14, no. 3, pp. 2235–2240, 2017. View at Publisher · View at Google Scholar
  • Lu Ren, Yujing Yan, Feihai Shen, Yisen Cheng, Zhiying Huang, Li Wang, and Jiamin Kong, “Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3β by increased SIRT3 expression,” Toxicology and Applied Pharmacology, vol. 342, pp. 1–13, 2018. View at Publisher · View at Google Scholar
  • Suwen Yang, Juan Wang, Qin Liu, Fangqiong Li, Dongxiao Zhao, Xin Jin, and Wei Wang, “ITRAQ-Based Proteomics Analysis of Triptolide on Human A549 Lung Adenocarcinoma Cells,” Cellular Physiology and Biochemistry, vol. 45, no. 3, pp. 917–934, 2018. View at Publisher · View at Google Scholar
  • Swati Singh, Veda P. Pandey, Manika Awasthi, and Upendra N. Dwivedi, “Natural products as anticancerous therapeutic molecules with special reference to enzymatic targets topoisomerase, COX, LOX and Aromatase,” Current Protein and Peptide Science, vol. 19, no. 3, pp. 238–274, 2018. View at Publisher · View at Google Scholar
  • Ma Yanchun, Wang Yi, Wang Lu, Qian Yu, Yang Jian, Kong Pengzhou, Yan Ting, Li Hongyi, Wang Fang, Cheng Xiaolong, and Cui Yongping, “Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway,” European Journal of Pharmacology, 2019. View at Publisher · View at Google Scholar