Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice
The effect of ACR and SN pretreatment on SOD activity in heart of mice. Vehicle-control group received normal saline +0.5% w/v methylcellulose, orally for 3 weeks. ACR was given (7.5 mg/kg, orally) for 3 weeks. SN was injected 7 days before ACR and daily thereafter throughout the study (3 weeks). Vit E (100 IU/Kg, three times per week) plus ACR were administrated for 3 weeks. SN alone at dose (100 mg/kg, intraperitoneally) was treated for 4 weeks. Data are expressed as mean ± SEM. *** versus vehicle-control group, ###, ##, and # versus ACR group, Tukey-Kramer test, .