Anti-Hepatitis B Virus Effect and Possible Mechanism of Action of 3,4-O-Dicaffeoylquinic Acid In Vitro and In Vivo
Figure 2
Histopathological changes of liver tissue from HBV transgenic mice (HE × 40). (a) A control untreated HBV transgenic mouse; (b) a lamivudine (100 mg/kg) treated HBV transgenic mouse; (c) a 3,4-dicaffeoylquinic acid (100 mg/kg) treated HBV transgenic mouse; (d) a 3,4-dicaffeoylquinic acid (50 mg/kg) treated HBV transgenic mouse. (a), (b), (c), and (d) do not show obvious pathological changes, which is probably related to the immunotolerance of HBV transgenic mice to HBV.
