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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 372878, 7 pages
http://dx.doi.org/10.1155/2012/372878
Research Article

Tocotrienol Supplementation Improves Late-Phase Fracture Healing Compared to Alpha-Tocopherol in a Rat Model of Postmenopausal Osteoporosis: A Biomechanical Evaluation

1Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Malaysia
2Cluster of Integrative Medicine, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
3Department of Orthopedics, UKM Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
4Department of Mechanical and Materials Engineering, Faculty of Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia

Received 29 May 2012; Accepted 15 June 2012

Academic Editor: Norazlina Mohamed

Copyright © 2012 Sharlina Mohamad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Consensus development conference. Diagnosis, prophylaxis and treatment of osteoporosis,” American Journal of Medicine, vol. 94, pp. 646–650.
  2. EFFO and NOF, “Who are candidates for prevention and treatment for osteoporosis?” Osteoporosis International, vol. 7, no. 1, pp. 1–6, 1997. View at Google Scholar
  3. B. Gullberg, O. Johnell, and J. A. Kanis, “World-wide projections for hip fracture,” Osteoporosis International, vol. 7, no. 5, pp. 407–413, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Cooper, G. Campion, and L. J. Melton, “Hip fractures in the elderly: a world-wide projection,” Osteoporosis International, vol. 2, no. 6, pp. 285–289, 1992. View at Publisher · View at Google Scholar · View at Scopus
  5. R. M. McCann, G. Colleary, C. Geddis et al., “Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model,” Journal of Orthopaedic Research, vol. 26, no. 3, pp. 384–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Yingjie, Z. Ge, W. Yisheng et al., “Changes of microstructure and mineralized tissue in the middle and late phase of osteoporotic fracture healing in rats,” Bone, vol. 41, no. 4, pp. 631–638, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Boyle, M. E. Leon, and P. Autier, “Epidemiology of osteoporosis,” Journal of Epidemiology and Biostatistics, vol. 6, no. 2, pp. 185–192, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. L. J. Melton, “Epidemiology of spinal osteoporosis,” Spine, vol. 22, no. 24, pp. 2S–11S, 1997. View at Google Scholar · View at Scopus
  9. R. L. Cruess and J. Dumont, “Healing of bone, tendon, and ligament,” in Fractures, C. A. Rock wood and D. P. Green, Eds., JB Lippincott, Philadelphia, Pa, USA, 1975. View at Google Scholar
  10. K. Dai and Y. Hao, “Quality of healing compared between osteoporotic fracture and normal traumatic fracture,” in Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials Techniques and Applications, L. Qin, H. K. Genant, J. F. Griffith, and K. S. Leung, Eds., pp. 531–541, Springer, Berlin, Germany, 2007. View at Google Scholar
  11. L. G. Raisz, “Local and systemic factors in the pathogenesis of osteoporosis,” The New England Journal of Medicine, vol. 318, no. 13, pp. 818–828, 1988. View at Google Scholar · View at Scopus
  12. X. J. Li, W. S. S. Jee, H. Z. Ke, S. Mori, and T. Akamine, “Age related changes of cancellous and cortical bone histomorphometry in female Sprague-Dawley rats,” Cells and Materials, supplement 1, pp. 25–35, 1991. View at Google Scholar
  13. T. J. Wronski and C. F. Yen, “The ovariectomized rat as an animal model for postmenopausal bone loss,” Cells and Materials, supplement 1, pp. 69–74, 1991. View at Google Scholar
  14. D. N. Kalu, “The ovariectomized rat model of postmenopausal bone loss,” Bone and Mineral, vol. 15, no. 3, pp. 175–191, 1991. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Klibanski, L. Adams-Campbell, T. Bassford et al., “Osteoporosis prevention, diagnosis, and therapy,” JAMA, vol. 285, no. 6, pp. 785–795, 2001. View at Google Scholar · View at Scopus
  16. J. L. Katz, “Anisotropy of Young's modulus of bone,” Nature, vol. 283, no. 5742, pp. 106–107, 1980. View at Google Scholar · View at Scopus
  17. J. Dequeker and G. R. Mundy, “Bone Structure and function,” in Rheumatology, J. Klippel and P. A. Dieppe, Eds., vol. 8–34, pp. 1–12, Mosby, London, UK, 1998. View at Google Scholar
  18. B. Czerny, A. Pawlik, Z. Juzyszyn, and Z. Myśliwiec, “The effect of tamoxifen and fluoride on bone mineral density, biomechanical properties and blood lipids in ovariectomized rats,” Basic and Clinical Pharmacology and Toxicology, vol. 95, no. 4, pp. 162–165, 2004. View at Google Scholar · View at Scopus
  19. C. H. Turner, W. R. Hinckley, M. E. Wilson, W. Zhang, and A. J. Dunipace, “Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats,” Calcified Tissue International, vol. 69, no. 1, pp. 51–57, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Bohatyrewicz, “Effects of fluoride on mechanical properties of femoral bone in growing rats,” Fluoride, vol. 32, no. 2, pp. 47–54, 1999. View at Google Scholar · View at Scopus
  21. D. Chachra, C. H. Turner, A. J. Dunipace, and M. D. Grynpas, “The effect of fluoride treatment on bone mineral in rabbits,” Calcified Tissue International, vol. 64, no. 4, pp. 345–351, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Namkung-Matthai, R. Appleyard, J. Jansen et al., “Osteoporosis influences the early period of fracture healing in a rat osteoporotic model,” Bone, vol. 28, no. 1, pp. 80–86, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. S. W. Xu, R. Yu, G. F. Zhao, and J. W. Wang, “Early period of fracture healing in ovariectomized rats,” Chinese Journal of Traumatology, vol. 6, no. 3, pp. 160–166, 2003. View at Google Scholar · View at Scopus
  24. A. O. Molster, N. R. Gjerdet, A. Alho, and G. Bang, “Fracture healing after rigid intramedullary nailing in rats,” Acta Orthopaedica Scandinavica, vol. 54, no. 3, pp. 366–373, 1983. View at Google Scholar · View at Scopus
  25. A. S. Nazrun, M. Norazlina, M. Norliza, and S. Ima Nirwana, “Tocotrienols as an anti-osteoporotic agent: the progress so far,” International Journal of Osteoporosis and Metabolic Disorders, vol. 4, no. 1, pp. 1–14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Serbinova, V. Kagan, D. Han, and L. Packer, “Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol,” Free Radical Biology and Medicine, vol. 10, no. 5, pp. 263–275, 1991. View at Publisher · View at Google Scholar · View at Scopus
  27. J. P. Kamat, H. D. Sarma, T. R. A. Devasagayam, K. Nesaretnam, and Y. Basiron, “Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes,” Molecular and Cellular Biochemistry, vol. 170, no. 1-2, pp. 131–137, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. A. A. Qureshi, S. A. Sami, W. A. Salser, and F. A. Khan, “Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans,” Atherosclerosis, vol. 161, no. 1, pp. 199–207, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. V. G. Mahadevappa, F. Sicillia, and B. J. Holub, “Effect of tocotrienol derivatives on collagenand ADP-induced human platelet aggregation,” in Proceedings of the International Palm Oil Conference on Nutirition and Health Aspects of Palm Oil (PORIM '91), pp. 36–38, Kuala Lumpur, Malaysia, 1991.
  30. W. Z. W. Ngah, Z. Jarien, M. M. San et al., “Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats,” American Journal of Clinical Nutrition, vol. 53, no. 4, pp. 1076–1081, 1991. View at Google Scholar · View at Scopus
  31. K. Nesaretnam, R. Stephen, R. Dils, and P. Darbre, “Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status,” Lipids, vol. 33, no. 5, pp. 461–469, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Norazlina, S. Ima-Nirwana, M. T. Gapor, and B. A. K. Khalid, “Palm vitamin E is comparable to α-tocopherol in maintaining bone mineral density in ovariectomised female rats,” Experimental and Clinical Endocrinology and Diabetes, vol. 108, no. 4, pp. 305–310, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Durak, G. Sonmez, B. Sarisozen, S. Ozkan, M. Kaya, and C. Ozturk, “Histological assessment of the effect of α-tocopherol on fracture healing in rabbits,” Journal of International Medical Research, vol. 31, no. 1, pp. 26–30, 2003. View at Google Scholar · View at Scopus
  34. D. Keskin, O. Karson, N. Ezirmik, and A. Ciftcioglu, “The effect of alpha-tocopherol on fracture healing in rabbits,” Arthroplasty Arthroscopic Surgery, vol. 10, pp. 207–210, 1999. View at Google Scholar
  35. E. Vialle, L. R. Vialle, and R. Boechat, “Producao de fractura padrinizada de femur em ratos,” Revista Brasileira de Ortopedia, vol. 39, pp. 323–329, 2004. View at Google Scholar
  36. T. Kubo, T. Shiga, J. Hashimoto et al., “Osteoporosis influences the late period of fracture healing in a rat model prepared by ovariectomy and low calcium diet,” Journal of Steroid Biochemistry and Molecular Biology, vol. 68, no. 5-6, pp. 197–202, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Nakamura, F. Furukawa, A. Nishikawa et al., “Oral toxicity of a tocotrienol preparation in rats,” Food and Chemical Toxicology, vol. 39, no. 8, pp. 799–805, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. S. L. Oo, P. Chang, and K. E. Chan, “Toxicological and pharmacological studies on palm vitee,” Nutrition Research, vol. 12, pp. S217–S222, 1992. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Gianello, W. C. Hall, E. Kennepohl, R. Libinaki, and E. Ogru, “Subchronic oral toxicity study of mixed tocopheryl phosphates in rats,” International Journal of Toxicology, vol. 26, no. 5, pp. 475–490, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. A. N. Shuid, S. Mohamad, N. Mohamed et al., “Effects of calcium supplements on fracture healing in a rat osteoporotic model,” Journal of Orthopaedic Research, vol. 28, no. 12, pp. 1651–1656, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. A. N. Shuid, Z. Mehat, N. Mohamed, N. Muhammad, and I. N. Soelaiman, “Vitamin E exhibits bone anabolic actions in normal male rats,” Journal of Bone and Mineral Metabolism, vol. 28, no. 2, pp. 149–156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. C. Y. Turk, M. Halici, A. Guney, H. Akgun, V. Sahin, and S. Muhtaroglu, “Promotion of fracture healing by vitamin E in rats,” Journal of International Medical Research, vol. 32, no. 5, pp. 507–512, 2004. View at Google Scholar · View at Scopus
  43. A. N. Shuid, S. Mohamad, N. Muhammad et al., “Effects of α-tocopherol on the early phase of osteoporotic fracture healing,” Journal of Orthopaedic Research, vol. 29, pp. 1732–1738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. B. H. Arjmandi, S. Juma, A. Beharka, M. S. Bapna, M. Akhter, and S. N. Meydani, “Vitamin E improves bone quality in the aged but not in young adult male mice,” Journal of Nutritional Biochemistry, vol. 13, no. 9, pp. 543–549, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. D. Foschi, F. Castoldi, E. Radaelli et al., “Hyaluronic acid prevents oxygen free-radical damage to granulation tissue: a study in rats,” International Journal of Tissue Reactions, vol. 12, no. 6, pp. 333–339, 1990. View at Google Scholar · View at Scopus
  46. E. Gokturk, A. Turgut, C. Baycu, I. Gunal, S. Seber, and Z. Gulbas, “Oxygen-free radicals impair fracture healing in rats,” Acta Orthopaedica Scandinavica, vol. 66, no. 5, pp. 473–475, 1995. View at Google Scholar · View at Scopus
  47. D. Maggio, M. Barabani, M. Pierandrei et al., “Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study,” The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1523–1527, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. A. N. Sontakke and R. S. Tare, “A duality in the roles of reactive oxygen species with respect to bone metabolism,” Clinica Chimica Acta, vol. 318, no. 1-2, pp. 145–148, 2002. View at Publisher · View at Google Scholar · View at Scopus