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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 383062, 9 pages
http://dx.doi.org/10.1155/2012/383062
Research Article

Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women

1Neuroscience Program and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2Neuroscience Laboratory Unit, Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
4Department of Pharmaceutical and Natural Products, Thailand Institute of Scientific and Technological Research, Pathumthani 12120, Thailand

Received 20 August 2011; Accepted 21 September 2011

Academic Editor: Angelo Antonio Izzo

Copyright © 2012 Naritsara Saenghong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The development of cognitive enhancers from plants possessing antioxidants has gained much attention due to the role of oxidative stress-induced cognitive impairment. Thus, this study aimed to determine the effect of ginger extract, or Zingiber officinale, on the cognitive function of middle-aged, healthy women. Sixty participants were randomly assigned to receive a placebo or standardized plant extract at doses of 400 and 800 mg once daily for 2 months. They were evaluated for working memory and cognitive function using computerized battery tests and the auditory oddball paradigm of event-related potentials at three different time periods: before receiving the intervention, one month, and two months. We found that the ginger-treated groups had significantly decreased P300 latencies, increased N100 and P300 amplitudes, and exhibited enhanced working memory. Therefore, ginger is a potential cognitive enhancer for middle-aged women.