Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells

Figure 5

CT inhibits tumor growth in PC-3 xenograft model. (a) Effect of CT on the growth of PC-3 cells in BALB/c athymic nude mice. From 3 days after inoculation, CT (10 mg/kg body wt) was given by i.p. injection with 2% Tween-80 as vehicle every other days. Tumor growth was monitored twice a week. (b) Effect of CT on final tumor weight after sacrifice. Values represent means ± SD. 𝑛=5. *𝑃<0.05 compared with untreated control. (c) Photographs of dissected tumors. (d) Effect of CT on body weights of mice at various time points. Values represent means ± SD. 𝑛=5.

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