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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 406296, 7 pages
http://dx.doi.org/10.1155/2012/406296
Research Article

Absence of Genotoxic and Mutagenic Effects of Zingiber zerumbet (L.) Smith (Zingiberaceae) Extract

1School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan
2Department of Internal Medicine, Pao Chien Hospital, Pingtung County, Ping Tung City 90064, Taiwan
3Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien 90701, Taiwan

Received 28 February 2012; Revised 17 May 2012; Accepted 25 May 2012

Academic Editor: Wagner Vilegas

Copyright © 2012 Chia Ju Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Nalawade, A. P. Sagare, C. Y. Lee, C. L. Kao, and H. S. Tsay, “Studies on tissue culture of Chinese medicinal plant resources in Taiwan and their sustainable utilization,” Botanical Bulletin of Academia Sinica, vol. 44, no. 2, pp. 79–98, 2003. View at Google Scholar · View at Scopus
  2. N. J. Yob, S. M. Jofrry, M. M. R. M. M. Affandi, L. K. Teh, M. Z. Salleh, and Z. A. Zakaria, “Zingiber zerumbet (L.) Smith: a review of its ethnomedicinal, chemical, and pharmacological uses,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 543216, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. R. D. Altman and K. C. Marcussen, “Effects of a ginger extract on knee pain in patients with osteoarthritis,” Arthritis & Rheumatism, vol. 44, no. 11, pp. 2531–2538, 2001. View at Google Scholar
  4. E. Langner, S. Greifenberg, and J. Gruenwald, “Ginger: history and use,” Advances in Therapy, vol. 15, no. 1, pp. 25–44, 1998. View at Google Scholar · View at Scopus
  5. M. R. Sulaiman, T. A. S. Tengku Mohamad, W. M. Shaik Mossadeq et al., “Antinociceptive activity of the essential oil of Zingiber zerumbet,” Planta Medica, vol. 76, no. 2, pp. 107–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Jantan, I. A. A. Rafi, and J. Jalil, “Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants,” Phytomedicine, vol. 12, no. 1-2, pp. 88–92, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. S. K. Tan, R. Pippen, R. Yusof, N. S. Abdul Rahman, H. Ibrahim, and N. Z. Khalid, “Screening of selected Zingiberaceae extracts for dengue-2 virus protease inhibitory activities,” Sunway Academic Journal, vol. 3, pp. 1–7, 2006. View at Google Scholar
  8. C. J. Chang, T. F. Tzeng, S. S. Liou, Y. S. Chang, and I. M. Liu, “Regulation of lipid disorders by ethanol extracts from Zingiber zerumbet in high-fat diet-induced rats,” Food Chemistry, vol. 132, no. 1, pp. 460–467, 2012. View at Google Scholar
  9. A. S. Al-Zubairi, A. B. Abdul, and M. M. Syam, “Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes,” Toxicology in Vitro, vol. 24, no. 3, pp. 707–712, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. C. J. Chang, T. F. Tzeng, S. S. Liou, Y. S. Chang, and I. M. Liu, “Acute and 28-day subchronic oral toxicity of an ethanol extract of Zingiber zerumbet (L.) Smith in rodents,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 608284, 11 pages, 2012. View at Publisher · View at Google Scholar
  11. OECD, “Guideline for the testing of chemical TG no. 471. bacterial reverse mutation test,” 1977, http://www.oecd.org/dataoecd/18/31/1948418.pdf.
  12. D. M. Maron and B. N. Ames, “Revised methods for the Salmonella mutagenicity test,” Mutation Research, vol. 113, no. 3-4, pp. 173–215, 1983. View at Google Scholar · View at Scopus
  13. OECD, “Guideline for the testing of chemical TG no. 473. In vitro mammalian chromosome aberration test,” 1970, http://www.oecd.org/dataoecd/18/33/1948434.pdf.
  14. Y. N. Huang, Y. L. Zhao, X. L. Gao et al., “Intestinal α-glucosidase inhibitory activity and toxicological evaluation of Nymphaea stellata flowers extract,” Journal of Ethnopharmacology, vol. 131, no. 2, pp. 306–312, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. Mammalian Mutagenicity Study Group, Japanese Environemtnal Mutagen Society, Atlas on Chromosome Aberration Induced by Chemicals, Asakura Shoten, Tokyo, Japan, 1988.
  16. OECD, “Guideline for the testing of chemical TG no. 474. mammalian erythrocyte micronucleus test,” 1997, http://www.oecd.org/dataoecd/18/34/1948442.pdf.
  17. W. Schmid, “The micronucleus test,” Mutation Research, vol. 31, no. 1, pp. 9–15, 1975. View at Google Scholar · View at Scopus
  18. I. S. Shin, C. S. Seo, H. K. Ha et al., “Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 696–703, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Ha, J. K. Lee, H. Y. Lee et al., “Genotoxicity assessment of a herbal formula, Ojeok-san,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 586–589, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. D. P. Lovell, D. Anderson, R. Albanese et al., “Statistical analysis on in vivo cytogenetic assays,” in Statistical Evaluation of Mutagenicity Test Data, D. J. Kirkland, Ed., pp. 184–232, Cambridge University, Cambridge, UK, 1989. View at Google Scholar
  21. A. Vikram, D. N. Tripathi, P. Ramarao, and G. B. Jena, “Evaluation of streptozotocin genotoxicity in rats from different ages using the micronucleus assay,” Regulatory Toxicology and Pharmacology, vol. 49, no. 3, pp. 238–244, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Schlegel, J. T. MacGregor, and R. B. Everson, “Assessment of cytogenetic damage by quantitation of micronuclei in human peripheral blood erythrocytes,” Cancer Research, vol. 46, no. 7, pp. 3717–3721, 1986. View at Google Scholar · View at Scopus
  23. C. J. Chang, T.-F. Tzeng, Y.-S. Chang, and I.-M. Liu, “Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed rats,” Planta Medica, vol. 78, no. 4, pp. 317–325, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Fujii, H. Nishioka, K. Wakame, B. A. Magnuson, and A. Roberts, “Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts,” Food and Chemical Toxicology, vol. 46, no. 12, pp. 3553–3562, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. O. Schimmer, F. Hafele, and A. Kruger, “The mutagenic potencies of plant extracts containing quercetin in Salmonella typhimurium TA98 and TA100,” Mutation Research, vol. 206, no. 2, pp. 201–208, 1988. View at Google Scholar · View at Scopus
  26. R. Edenharder, H. Krieg, V. Köttgen, and K. L. Platt, “Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids,” Mutation Research, vol. 537, no. 2, pp. 169–181, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Tanaka, M. Shimizu, H. Kohno et al., “Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet,” Life Sciences, vol. 69, no. 16, pp. 1935–1945, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. S. A. S. Sakinah, S. Tri Handayani, and L. P. A. Hawariah, “Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/ Bcl-2 ratio,” Cancer Cell International, vol. 7, article 4, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Yang, L. Zhong, L. Jiang et al., “6-gingerol prevents patulin-induced genotoxicity in HepG2 cells,” Phytotherapy Research, vol. 25, no. 10, pp. 1480–1485, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Barros, C. D. Ropke, T. C. H. Sawada, V. V. Da Silva, S. M. M. Pereira, and S. B. D. M. Barros, “Assessment of acute and subchronic oral toxicity of ethanolic extract of Pothomorphe umbellata L. Miq. (Pariparoba),” Brazilian Journal of Pharmaceutical Sciences, vol. 41, no. 1, pp. 53–61, 2005. View at Google Scholar · View at Scopus