Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice
Figure 1
Histological micrograph of liver sections of mice stained with haematoxy lin and eosin. Liver sections excised from the normal control mice (a, ×40) showed normal structure of the hepatocytes with defined cell lining and round nuclei (b, ×100). Histological sections of mice fed with 50% ethanol showed damage of the liver structure as indicated by infiltration of monocytes (block arrow head) (c, ×40), steatosis (filled arrow), and the presence of necrotic cells (block arrow) (d, ×100). Treatment with 15 mg/kg BW of P. niruri, the positive control, indicated normalization of the damaged hepatocytes (e, ×40). A great reduction of fat droplets (filled arrow), and the presence of a minute quantity of necrotic cells (block arrow) (f, ×100) could also be observed in this group. On the other hand, section of liver treated by ESL showed recovery of hepatocytes into normal shape (g, ×40), along with lesser fat droplets (filled arrow) and mild monocytes infiltration (block arrow) (H, ×100). When the concentration was increased to 15 mg/kg BW (i, ×40), mild monocytes infiltration was observed (j, ×100). Upon treatment with ESH, structure of the hepatocytes reverted to normal (k, ×40) with defined cell lining and round nuclei (l, ×100). Centrilobular vein (CV), peripheral vein (PV), hepatic artery (HA). Bar = 50 μm.
