Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 434782, 7 pages
http://dx.doi.org/10.1155/2012/434782
Research Article

Levels of Tannins and Flavonoids in Medicinal Plants: Evaluating Bioprospecting Strategies

1Natural Products Laboratory, Pharmacy Department, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
2Laboratory of Applied Ethnobotany, Department of Biology, Federal Rural University of Pernambuco, Avenida Dom Manoel de Medeiros s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil

Received 14 June 2011; Revised 23 July 2011; Accepted 23 July 2011

Academic Editor: Rômulo Romeu da Nóbrega Alves

Copyright © 2012 Clarissa Fernanda de Queiroz Siqueira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Kaileh, W. V. Berghe, E. Boone, T. Essawi, and G. Haegeman, “Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity,” Journal of Ethnopharmacology, vol. 113, no. 3, pp. 510–516, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Z. Shu, “Recent natural products based drug development: a pharmaceutical industry perspective,” Journal of Natural Products, vol. 61, no. 8, pp. 1053–1071, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. P. A. Cox, “Ethnopharmacology and the search for new drugs,” in Proceedings of the Ciba Foundation Symposium, D. J. Chadwick and J. Marsh, Eds., vol. 47–55, pp. 40–47, John Wiley and Sons, Chichester, UK, 1990.
  4. N. R. Farnsworth and A. S. Bingel, “Problems and prospects of discovering new drugs from higher plants by pharmacological screening,” in New Natural Products and Plant Drugs with Pharmaceutical, Biological or Therapeutic Activity, H. Wagner and P. Wolff, Eds., Springer, Heidelberg, Germany, 1977. View at Google Scholar
  5. I. R. Leal, J. M. C. Silva, M. Tabarelli, and T. E. Lacher Jr., “Mudando o curso da conservação da biodiversidade na Caatinga do Nordeste do Brazil,” Megadiversidade, vol. 1, no. 1, pp. 139–146, 2005. View at Google Scholar
  6. E. Douwes, N. R. Crouch, T. J. Edwards, and D. A. Mulholland, “Regression analyses of southern African ethnomedicinal plants: informing the targeted selection of bioprospecting and pharmacological screening subjects,” Journal of Ethnopharmacology, vol. 119, no. 3, pp. 356–364, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Canales, T. Hernández, J. Caballero et al., “Informant consensus factor and antibacterial activity of the medicinal plants used by the people of San Rafael Coxcatlán, Puebla, México,” Journal of Ethnopharmacology, vol. 97, no. 3, pp. 429–439, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. T. A. S. Araújo, N. L. Alencar, E. L. C. Amorim, and U. P. Albuquerque, “A new approach to study medicinal plants with tannins and flavonoids contents from the local knowledge,” Journal of Ethnopharmacology, vol. 120, no. 1, pp. 72–80, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. U. P. Albuquerque, P. M. Medeiros, A. L. S. Almeida et al., “Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach,” Journal of Ethnopharmacology, vol. 114, no. 3, pp. 325–354, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. S. L. Cartaxo, M. M. A. Souza, and U. P. Albuquerque, “Medicinal plants with bioprospecting potential used in semi-arid northeastern Brazil,” Journal of Ethnopharmacology, vol. 131, no. 2, pp. 326–342, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. U. P. Albuquerque and N. Hanazaki, “As pesquisas etnodirigidas na descoberta de novos fármacos de interesse médico e farmacêutico: fragilidades e perspectivas,” Brazilian Journal of Pharmacognosy, vol. 16, pp. 678–689, 2006. View at Google Scholar
  12. F. J. A. Matos, Farmácias Vivas, UFC/SEBRAE, Fortaleza, Brazil, 4th edition, 2002.
  13. R. R. N. Alves, N. A. L. Neto, S. E. Brooks, and U. P. Albuquerque, “Commercialization of animal-derived remedies as complementary medicine in the semi-arid region of Northeastern Brazil,” Journal of Ethnopharmacology, vol. 124, no. 3, pp. 600–608, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. R. R. N. Alves and I. M. L. Rosa, “Biodiversity, traditional medicine and public health: where do they meet?” Journal of Ethnobiology and Ethnomedicine, vol. 3, no. 14, pp. 1–9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. R. R. N. Alves and I. L. Rosa, “From cnidarians to mammals: the use of animals as remedies in fishing communities in NE Brazil,” Journal of Ethnopharmacology, vol. 107, no. 2, pp. 259–276, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. R. N. Alves and I. L. Rosa, “Why study the use of animal products in traditional medicines?” Journal of Ethnobiology and Ethnomedicine, vol. 1, pp. 1–5, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. C. F. C. B. R. Almeida, T. C. Lima Silva, E. L. C. Amorim, M. B. S. Maia, and U. P. Albuquerque, “Life strategy and chemical composition as predictors of the selection of medicinal plants from the caatinga (Northeast Brazil),” Journal of Arid Environments, vol. 62, no. 1, pp. 127–142, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. J. M. Monteiro, U. P. D. Albuquerque, E. M. F. Lins-Neto, T. A. S. Araújo, and E. L. C. D. Amorim, “Use patterns and knowledge of medicinal species among two rural communities in Brazil's semi-arid northeastern region,” Journal of Ethnopharmacology, vol. 105, no. 1-2, pp. 173–186, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. N. L. Alencar, T. A. S. Araújo, E. L. C. Amorim, and U. P. Albuquerque, “Can the apparency hypothesis explain the selection of medicinal plants in an area of caatinga vegetation? A chemical perspective,” Acta Botanica Brazilica, vol. 23, no. 3, pp. 910–911, 2009. View at Google Scholar · View at Scopus
  20. F. M. Macedo, G. T. Martins, C. S. O. Mendes, C. M. Silva, C. G. Rodrigues, and D. A. Oliveira, “Determinação de compostos fenólicos totais em barbatimão [Stryphnodendron adstringens (Mart) Coville],” Revista Brazileira de Biociências, vol. 5, no. 2, pp. 1164–1165, 2007. View at Google Scholar
  21. R. Amarowicz, G. A. Dykes, and R. B. Pegg, “Antibacterial activity of tannin constituents from Phaseolus vulgaris, Fagoypyrum esculentum, Corylus avellana and Juglans nigra,” Fitoterapia, vol. 79, no. 3, pp. 217–219, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Hayet, M. Maha, A. Samia et al., “Antimicrobial, antioxidant, and antiviral activities of Retama raetam (Forssk.) Webb flowers growing in Tunisia,” World Journal of Microbiology and Biotechnology, vol. 24, no. 12, pp. 2933–2940, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Tian, B. Li, B. Ji et al., “Antioxidant and antimicrobial activities of consecutive extracts from Galla chinensis: the polarity affects the bioactivities,” Food Chemistry, vol. 113, no. 1, pp. 173–179, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Nomura, T. Takahashi, N. Nagata et al., “Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells,” Biological and Pharmaceutical Bulletin, vol. 31, no. 7, pp. 1403–1409, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Aslan, D. O. Didem, O. Nilufer, S. Ekrem, and Y. Erdem, “In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats,” Journal of Ethnopharmacology, vol. 109, no. 1, pp. 54–59, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Sharma, G. Viswanath, R. Salunke, and P. Roy, “Effects of flavonoid-rich extract from seeds of Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice,” Food Chemistry, vol. 110, no. 3, pp. 697–705, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. V. S. Muthusamy, S. Anand, K. N. Sangeetha, S. Sujatha, B. Arun, and B. S. Lakshmi, “Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition,” Chemico-Biological Interactions, vol. 174, no. 1, pp. 69–78, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Klein, J. Kim, K. Himmeldirk, Y. Cao, and X. Chen, “Antidiabetes and anti-obesity activity of Lagerstroemia speciosa,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 4, pp. 401–407, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. U. J. Jung, M. K. Lee, Y. B. Park, M. A. Kang, and M. S. Choi, “Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 7, pp. 1134–1145, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Venkatesan, V. Thiyagarajan, S. Narayanan et al., “Anti-diarrhoeal potential of asparagus racemosus wild root extracts in laboratory animals,” Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 1, pp. 39–45, 2005. View at Google Scholar · View at Scopus
  31. P. A. Nwafor and A. I. L. Bassey, “Evaluation of anti-diarrhoeal and anti-ulcerogenic potential of ethanol extract of Carpolobia lutea leaves in rodents,” Journal of Ethnopharmacology, vol. 111, no. 3, pp. 619–624, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. H. O. C. Mbagwu and O. O. Adeyemi, “Anti-diarrhoeal activity of the aqueous extract of Mezoneuron benthamianum Baill (Caesalpiniaceae),” Journal of Ethnopharmacology, vol. 116, no. 1, pp. 16–20, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. G. J. Amabeoku, “Antidiarrhoeal activity of Geranium incanum Burm. f. (Geraniaceae) leaf aqueous extract in mice,” Journal of Ethnopharmacology, vol. 123, no. 1, pp. 190–193, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. CONDEPE/FIDEN, “Altinho Perfil Municipal de 2004,” 2005, Recife, Brazil. View at Google Scholar
  35. U. P. Albuquerque, L. G. S. Nascimento, F. J. A. C. O. Vieira, C. M. A. D. Almeida, and A. C. O. Silva, “"Return" and extension actions after ethnobotanical research: the perceptions and expectations of a rural community in semi-arid Northeastern Brazil,” Journal of Agricultural and Environmental Ethics, pp. 1–14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. E. M. F. Lins-Neto, N. Peroni, and U. P. Albuquerque, “Traditional knowledge and management of Umbu (Spondias tuberosa, Anacardiaceae): an endemic species from the semi-arid region of Northeastern Brazil,” Economic Botany, vol. 64, no. 1, pp. 11–21, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. N. L. Alencar, T. A. S. Araújo, E. L. C. Amorim, and U. P. Albuquerque, “The inclusion and selection of medicinal plants in traditional pharmacopoeias-evidence in support of the diversification hypothesis,” Economic Botany, vol. 64, no. 1, pp. 68–79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. S. S. Sieber, P. M. Medeiros, and U. P. Albuquerque, “Local perception of environmental change in a semi-arid area of Northeast Brazil: a new approach for the use of participatory methods at the level of family units,” Journal of Agricultural and Environmental Ethics, pp. 1–21, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. L. L. Santos, M. A. Ramos, S. I. Silva, M. F. de Sales, and U. P. Albuquerque, “Caatinga ethnobotany: anthropogenic landscape modification and useful species in Brazil's semi-arid Northeast,” Economic Botany, vol. 63, no. 4, pp. 363–374, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. A. E. Hagerman, “Radial diffusion method for determining tannin in plant extracts,” Journal of Chemical Ecology, vol. 13, no. 3, pp. 437–448, 1987. View at Publisher · View at Google Scholar · View at Scopus
  41. D. L. V. Cabral, T. J.S. Peixoto Sobrinho, E. L.C. Amorim, and U. P. Albuquerque, “Relationship of biometric parameters on the concentration of tannins in two medicinal plantsa—case study,” Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, vol. 9, no. 5, pp. 368–376, 2010. View at Google Scholar
  42. E. L. C. Amorim, J. E. Nascimento, J. M. Monteiro, T. J. S. Peixoto Sobrinho, T. A. S. Araújo, and U. P. Albuquerque, “A simple and accurate procedure for determination of tannin and flavonoid levels and some aplications in ethnobotany and ethnopharmacology,” Functional Ecosystems and Communities, vol. 2, no. 1, pp. 88–94, 2008. View at Google Scholar
  43. M. Ayres, M. J. Ayres, D. L. Ayres, and S. A. Santos, “BioEstat 2.0: aplicações estatísticas nas áreas das ciências biológicas e médicas,” Sociedade Civil Mamirauá, 2000. View at Google Scholar
  44. S. Rani, N. Ahamed, S. Rajaram, R. Saluja, S. Thenmozhi, and T. Murugesan, “Short communication anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract in rats,” Journal of Ethnopharmacology, vol. 68, no. 1–3, pp. 315–319, 1999. View at Publisher · View at Google Scholar · View at Scopus
  45. L. Panizzi, C. Caponi, S. Catalano, P. L. Cioni, and I. Morelli, “In vitro antimicrobial activity of extracts and isolated constituents of Rubus ulmifolius,” Journal of Ethnopharmacology, vol. 79, no. 2, pp. 165–168, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. M. R. Pansera, A. C. A. Santos, K. Paese et al., “Análise de taninos totais em plantas aromáticas e medicinais cultivadas no Nordeste do Rio Grande do Sul,” Revista Brazileira de Farmacognosia, vol. 13, no. 1, pp. 27–32, 2003. View at Google Scholar
  47. M. Kamijo, T. Kanazawa, M. Funaki, M. Nishizawa, and T. Yamagishi, “Effects of Rosa rugosa petals on intestinal bacteria,” Bioscience, Biotechnology and Biochemistry, vol. 72, no. 3, pp. 773–777, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. J. E. Carretero, F. D. Reguera, S. López-Argüeta Álvarez, and J. L. Montes, “A comparative analysis of response to ORS (oral rehydration solution) vs. ORS + gelatin tannate in two cohorts of pediatric patients with acute diarrhea,” Revista Española de Enfermedades Digestivas, vol. 101, no. 1, pp. 41–48, 2009. View at Google Scholar · View at Scopus
  49. R. A. Sá, A. C. C. Argolo, T. H. Napoleão et al., “Antioxidant, Fusarium growth inhibition and Nasutitermes corniger repellent activities of secondary metabolites from Myracrodruon urundeuva heartwood,” International Biodeterioration and Biodegradation, vol. 63, no. 4, pp. 470–477, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. R. Dall'Agnol, A. Ferraz, A. P. Bernardi et al., “Antimicrobial activity of some Hypericum species,” Phytomedicine, vol. 10, no. 6-7, pp. 511–516, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Corrales, J. H. Han, and B. Tauscher, “Antimicrobial properties of grape seed extracts and their effectiveness after incorporation into pea starch films,” International Journal of Food Science and Technology, vol. 44, no. 2, pp. 425–433, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. X. Lozoya, V. Navarro, J. T. Arnason, and E. Kourany, “Experimental evaluation of Mimosa tenuiflora (willd.) poir. (Tepescohuite) I. - screening of the antimicrobial properties of bark extracts,” Archivos de Investigacion Medica, vol. 20, no. 1, pp. 87–93, 1989. View at Google Scholar · View at Scopus
  53. M. Heinrich, M. Kuhnt, C. W. Wright et al., “Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico),” Journal of Ethnopharmacology, vol. 36, no. 1, pp. 81–85, 1992. View at Google Scholar · View at Scopus
  54. M. Meckes-Lozoya, X. Lozoya, and J. L. Gonzalez, “In vitro pharmacological properties of some extracts of Mimosa tenuiflora (tepescohuite),” Archivos de Investigacion Medica, vol. 21, no. 2, pp. 163–169, 1990. View at Google Scholar · View at Scopus
  55. N. E. Hernández, M. L. Tereschuk, and L. R. Abdala, “Antimicrobial activity of flavonoids in medicinal plants from Tafi del Valle (Tucuman, Argentina),” Journal of Ethnopharmacology, vol. 73, no. 1-2, pp. 317–322, 2000. View at Publisher · View at Google Scholar · View at Scopus
  56. M. L. Tereschuk, M. V. Q. Riera, G. R. Castro, and L. R. Abdala, “Antimicrobial activity of flavonoids from leaves of Tagetes minuta,” Journal of Ethnopharmacology, vol. 56, no. 3, pp. 227–232, 1997. View at Publisher · View at Google Scholar · View at Scopus
  57. J. P. Rauha, S. Remes, M. Heinonen et al., “Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds,” International Journal of Food Microbiology, vol. 56, no. 1, pp. 3–12, 2000. View at Publisher · View at Google Scholar · View at Scopus
  58. V. S. N. Rao, F. A. Santos, T. T. Sobreira, M. F. Souza, C. L. Melo, and E. R. Silveira, “Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa,” Planta Medica, vol. 63, no. 2, pp. 146–149, 1997. View at Google Scholar · View at Scopus
  59. J. Gálvez, J. Duarte, F. Sánchez De Medina, J. Jiménez, and A. Zarzuelo, “Inhibitory effects of quercetin on guinea-pig ileum contractions,” Phytotherapy Research, vol. 10, no. 1, pp. 66–69, 1996. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Galvez, M. E. Crespo, J. Jimenez, A. Suarez, and A. Zarzuelo, “Antidiarrhoeic activity of quercitrin in mice and rats,” Journal of Pharmacy and Pharmacology, vol. 45, no. 2, pp. 157–159, 1993. View at Google Scholar · View at Scopus
  61. K. L. Da Silva and V. C. Filho, “Plants of the genus bauhinia: chemical composition and pharmacological potential,” Quimica Nova, vol. 25, no. 3, pp. 449–454, 2002. View at Google Scholar · View at Scopus