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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 436959, 12 pages
Review Article

Role of Mesotherapy in Musculoskeletal Pain: Opinions from the Italian Society of Mesotherapy

1The Italian Society of Mesotherapy, Rome, Italy
2Emergency Care, Department of Intensive Care, Pain Medicine, and Anaesthesiology, Tor Vergata Polyclinic, University of Tor Vergata, 00133 Rome, Italy

Received 6 November 2011; Revised 5 February 2012; Accepted 24 February 2012

Academic Editor: Adair Roberto Soares Santos

Copyright © 2012 Massimo Mammucari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mesotherapy is the injection of active substances into the surface layer of the skin. This method allows a slower spread, higher levels, and longer lasting effects of drugs in the tissues underlying the site of injection (skin, muscle, and joint) compared with those following intramuscular injection. This technique is useful when a local pharmacological effect is required and relatively high doses of drug in the systemic circulation are not. Mesotherapy should only be undertaken following a complete clinical workup and subsequent diagnosis. Encouraging results have been reported in randomized, controlled clinical trials and in observational studies involving patients with various forms of musculoskeletal pain. Recommendations by experts from the Italian Society of Mesotherapy for appropriate use of mesotherapy in musculoskeletal pain and an algorithm for treating localized painful conditions are provided.