NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36
Figure 5
μ-opioid receptor agonist DAMGO abolishes the increase in NMDAR-mediated EPSC induced by low frequency stimulation at ST36. (a) Representative traces of NMDAR-mediated EPSC. (b) The increase of NMDAR-mediated EPSC in labeled DMV neurons induced by ST36 stimulation is reduced by bath perfusion of μ-opioid receptor agonist DAMGO and reversed by a specific μ-opioid receptor antagonist naloxonazine. , compared to control; , compared to the stimulated rats, , one-way ANOVA followed by test. (c) Representative traces of NMDAR-mediated EPSC induced by paired-pulse. (d) The PPR decreased by ST36 stimulation is increased by DAMGO. , -8, compared to ST36 stimulation and ST36 stimulation with naloxonazine, one-way ANOVA followed by test.
