Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients

Table 3

Changes in plasma glucose, HbA_1C, HOMA-IR, HOMA-β, insulin, and C-peptide levels from week 4 to 12.

	GP group; 𝑛=12	Placebo group; 𝑛=13	𝑃
Change in FPG (mmol/L)	−2.9 ± 1.7	−0.9 ± 0.6	<0.001
Change in 30 minutes plasma glucose (mmol/L)	−1.8 ± 3.0	+1.2 ± 2.7	0.015
Change in 120 minutes plasma glucose (mmol/L)	−3.6 ± 6.3	+1.3 ± 2.8	0.017
Change in fasting plasma insulin (pmol/L)	4.3 ± 56.7	7.8 ± 90.9	0.911
Change in 30 minutes plasma insulin (pmol/L)	75.4 ± 139.2	5.4 ± 119.4	0.193
Change in 120 minutes plasma insulin (pmol/L)	7.2 ± 270.6	−68.4 ± 170.4	0.411
Change in fasting plasma C-peptide (ng/mL)	0.12 ± 0.91	0.29 ± 1.46	0.714
Change in 30 minutes C-peptide (ng/mL)	0.52 ± 1.79	0.29 ± 1.93	0.774
Changes in HbA1C	−2.0 ± 0.9	−0.7 ± 0.5	<0.001
Change in HOMA-IR	−2.3 ± 3.4	−0.3 ± 5.8	0.311
Change in HOMA-𝛽	62.3 ± 59.3	18.8 ± 61.2	0.085

Results are means ± SD of patients in each group.