Impact of Global Normalization in fMRI Acupuncture Studies

Table 2

Significant brain regions of PSGS < NO PSGS.

				Acupuncture					Tactile
Regions			Talairach		𝑡-value	Voxels		Talairach		𝑡-value	Voxels
		x	y	z			x	y	z
Inferior frontal gyrus											(+95)
BA 9	L						−56	7	27	5.3	14
	R						59	10	30	4.1	8
BA 44	L						−53	10	19	4.4	16
	R						59	12	16	4.3	11
BA 45	L						−53	13	21	4.3	5
	R						56	18	5	4.2	13
BA 47	L						−53	20	−1	4.0	8
	R	42	20	−14	3.9	5	53	20	2	4.4	18
Middle frontal gyrus											(+38)
BA 6	R						−42	2	50	4.3	5
BA 9	L						−50	5	36	3.8	5
	R						53	8	36	3.9	9
Superior frontal gyrus
BA 6	R
Precentral gyrus											(+89)
BA 4	L						−59	−16	34	4.5	8
	R						62	−13	34	4.9	8
BA 6	L						−56	4	30	5.0	20
	R						59	0	8	4.1	6
BA 44	L						−45	0	6	4.4	14
	R						59	6	8	4.5	16
Postcentral gyrus						(+47)					(+186)
BA 1, 2, 3	L	−62	−22	31	4.1	19	−62	−19	31	5.8	42
	R	65	−22	34	3.9	6	59	−19	31	4.5	28
BA 40	L	−62	−22	18	4.2	27	−56	−23	15	6.4	21
	R						62	−25	21	5.0	12
BA 43	L						−50	−14	15	5.4	10
	R						53	−17	17	5.3	12
Inferior parietal lobule						(+51)					(+180)
BA 40	L	−62	−25	29	4.3	33	−56	−28	24	5.7	85
	R	65	−33	29	4.5	33	56	−31	26	5.1	42
Thalamus	L						−15	−11	6	4.4	47
	R						9	−11	3	3.9	10
Insula						(+6)					(+62)
BA 13	L	−53	−31	21	4.1	9	−48	−22	18	6.4	107
	R						48	−20	15	4.9	47
BA 47	R
Claustrum	L						−33	0	8	4.5	23
	R						36	−2	8	3.7	6
Extranuclear											(+104)
Putamen	L						−27	3	0	4.0	22
	R
Subgyral											(+80)
BA 21	L						−42	−3	−7	4.5	6
	R						42	−9	−7	3.9	3
Middle temporal gyrus											(+18)
Superior temporal gyrus						(+11)					(+158)
BA 13	L						−42	−20	9	4.3	8
BA 22	L	−56	0	3	4.0	7	−56	6	2	6.6	51
	R						59	3	5	5.7	25
BA 38	L						−42	8	−11	4.1	10
	R						45	8	−8	4.0	8
BA 41	L						−53	−20	9	5.5	19
	R
BA 42	L	−62	−31	21	4.0	10	−62	−20	12	5.7	13
	R						56	−28	15	4.0	9
Transverse temporal gyrus											(+6)
BA 41	L						−53	−23	12	5.7	14
	R						50	−17	12	5.3	5
BA 42	L
	R						59	−14	12	4.9	5
Cerebellum
Declive	L						−33	−65	−19	4.3	25
	R						30	−71	−19	4.0	22
Pyramis	L						−27	−74	−32	4.6	6
	R						30	−72	−32	4.1	3
Tuber	L						−33	−74	−27	4.1	6
Uvula	L						−33	−74	−24	3.9	11

The coordination of voxel with the maximal 𝑡 within each region is listed. The regions are thresholded at 𝑃<0.001, uncorrected. The number of detected white matter is listed in the parenthesis of each region.
Abbreviations: BA: Brodmann area; L: left; R: right.