A Study of the Wound Healing Mechanism of a Traditional Chinese Medicine, Angelica sinensis, Using a Proteomic Approach

Table 1

Proteins showing altered abundance after treatment with either AS extract or FA compared to the DMSO control and identified by LC-MS/MS.

ID	Protein identity	Accession number	Abbreviation	MW/pI	Score	Match peptide	Sequence coverage (%)		AS/DMSO		FA/DMSO
1	Peroxiredoxin-6	P30041	PRDX6	25019/6.00	40	3	12	↑	1.91	↑	1.96
2	Annexin A2	P07355	ANXA2	38580/7.57	110	3	9	↑	1.50	↑	1.51
3	Peroxiredoxin-4	Q13162	PRDX4	30521/5.86	105	4	14	↑	2.02	↑	1.88
4	Triosephosphate isomerase	P60174	TPIS	26713/6.45	236	7	27	↑	1.86	↑	1.52
5	Parkinson disease protein 7	Q99497	PARK7	19878/6.33	67	2	12	↑	1.57	↑	1.77
6	GTP-binding protein SAR1a	Q9NR31	SAR1A	22353/6.21	45	1	5	↑	1.72	↑	1.51
7	Glutathione S-transferase P	P09211	GSTP1	23341/5.43	214	7	43	↑	1.70	↑	1.50
8	Glutathione S-transferase P	P09211	GSTP1	23341/5.44	174	6	38	↑	2.54	↑	1.50
9	Peroxiredoxin-2	P32119	PRDX2	21878/5.66	135	5	23	↑	1.77	↑	1.96
10	Translationally controlled tumor protein	P13693	TCTP	195834.84	119	4	17	↑	1.57	↑	1.71
11	Protein disulfide-isomerase A3	P30101	PDIA3	56747/5.98	1019	27	40	↓	0.53	↓	0.51
12	Ubiquitin-conjugating enzyme E2	P61088	UBE2N	17127/6.13	2.5 (criteria)	4	26.3	↑	2.04	↑	1.77
13	Nucleoside diphosphate kinase B	P22392	NDKB	17287/8.52	70	4	28	↓	0.63	↓	0.63
14	Microtubule-associated protein RP/EB family member1	Q15691	MARE1	29980/5.02	117	4	20	↓	0.49	↓	0.62
15	Protein SEC13 homolog	P55735	SEC13	35518/5.22	130	4	9	↑	1.64	↑	1.60
16	Serine-threonine kinase receptor-associated protein	Q9y3f4	STRAP	38414/4.98	2.5 (criteria)	5	18.9	↑	1.97	↑	1.78
17	Heat shock protein 60	P10809	HSP60	61016/5.70	379	15	19	↑	1.99	↑	1.56
18	Isoform A of eukaryotic translation initiation factor 5A-1	P63241-2	IF5A1	20157/5.07	2.5 (criteria)	4	21.2	↓	0.56
19	L-Lactate dehydrogenase B chain	P07195	LDHB	36615/5.17	115	5	17	↑	2.01
20	proteosome activator complex subunit 1	Q06323	PSME1	28705/5.78	289	7	27	↑	2.77
21	Heat shock protein beta-1	P04792	HSPB1	22768/5.98	223	9	37	↑	1.65
22	Phosphoglycerate kinase 1	P00558	PGK1	44586/8.30	94	1	4	↑	2.05
23	Vimentin	P08670	VIME	53619/5.06	2.5 (criteria)	10	23.8	↓	0.64
24	Vimentin	P08670	VIME	53619/5.07	2.5 (criteria)	10	23.8	↓	0.43
25	Annexin A5	P08758	ANXA5	35914/4.94	272	13	40	↓	0.47
26	Calpain small subunit 1	P04632	CAPNS1	28298/5.05	2.5 (criteria)	8	36.2	↑	1.62
27	Heat shock protein 6	O14558	HSP6	17125/5.95	75	4	38	↑	1.67
28	Galectin-1	P09382	LEG1	14706/5.34	81	3	19	↓	0.66
29	Synaptic vesicle membrane protein VAT-1 homolog	Q99536	VAT1	41893/5.88	2.5 (criteria)	8	28	↑	1.78
30	Ferritin light chain	P02792	FRIL	20007/5.51	2.5 (criteria)	3	20			↑	2.48
31	Stathmin	P16949	P08758	17292/5.76	134	6	36			↑	1.96
32	Glutaredoxin	O76003	GLRX3	37408/5.31	152	5	18			↑	1.66
33	Actin-related protein 2/3 complex subunit 5	O15511	ARPC5	16310/5.47	179	6	27			↑	1.53
34	Annexin A5	P08758	ANXA5	35914/4.94	2.5 (criteria)	16	65			↑	1.53