Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9
Figure 3
Effect of hispolon on the CCl4-induced liver damage. Animals were i.p. treated with the hispolon (5, 10, and 20 mg/kg) once daily for consecutive seven days. One hour after the final hispolon treatment, the rats were treated with CCl4 (1.5 mL/kg, i.p.). Rats were sacrificed 24 h after the CCl4 administration and liver was removed, fixed, and embedded in paraffin. Sections were stained with hematoxylin-eosin (×100) and observed under the light microscopy. (a) Control; (b) CCl4 (0.5 mL/kg); (c) silymarin (200 mg/kg) + CCl4 (0.5 mL/kg); (d) hispolon (5 mg/kg) + CCl4 (0.5 mL/kg); (e) hispolon (10 mg/kg) + CCl4 (0.5 mL/kg); (f) hispolon (20 mg/kg) +CCl4 (0.5 mL/kg).
