Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9
Figure 8
Effect of hispolon on CCl4-injected rats the activity of MMP-9 expression. CCl4- injected rats were treated with 5, 10, and 20 mg/kg of hispolon for 24 h and then subjected to gelatin zymography to analyze the activities of MMP-9 in the liver (a). The relative intensities were evaluated by MMP-9 (b) proteins with the use of the Kodak Molecular Imaging software. Western blot analysis of hispolon on CCl4-injected rats the activation of MMP-9 in rats liver (c). The relative intensities were evaluated by MMP-9 (d) proteins with the use of the Kodak Molecular Imaging software. β-actin was used as internal control for equal loading of proteins. The values are reported as the mean ± S.D. of six rats per group. ### as compared to control group; *, **, and *** as compared to CCl4-treated group.
