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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 483123, 10 pages
http://dx.doi.org/10.1155/2012/483123
Research Article

Acupuncture Alleviates Colorectal Hypersensitivity and Correlates with the Regulatory Mechanism of TrpV1 and p-ERK

1Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
2Basic Medicine, School of Basic Medical Science, Capital Medical University, Beijing 100069, China
3Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China

Received 11 June 2012; Revised 16 August 2012; Accepted 12 September 2012

Academic Editor: Ying Xia

Copyright © 2012 Shao-Jun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. A. Drossman, W. E. Whitehead, and M. Camilleri, “Irritable bowel syndrome: a technical review for practice guideline development,” Gastroenterology, vol. 112, no. 6, pp. 2120–2137, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Fan, X. Wu, Z. Cao, S. Chen, C. Owyang, and Y. Li, “Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats,” Gastroenterology, vol. 136, no. 5, pp. 1732–e3, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. Z. Cao, X. Wu, S. Chen et al., “Anterior cingulate cortex modulates visceral pain as measured by visceromotor responses in viscerally hypersensitive rats,” Gastroenterology, vol. 134, no. 2, pp. 535–543, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Yan, B. Cao, J. Xu, C. Hao, X. Zhang, and Y. Li, “Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats,” Neurobiology of Learning and Memory, vol. 97, no. 1, pp. 156–164, 2012. View at Publisher · View at Google Scholar
  5. J. S. Han, “Acupuncture analgesia: areas of consensus and controversy,” Pain, vol. 152, no. 3, supplement 1, pp. S41–S48, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. H. Tu, W. C. Chung, C. Y. Yang, and D. S. Tzeng, “A comparison between acupuncture versus zolpidem in the treatment of primary insomnia,” Asian Journal of Psychiatry, vol. 5, no. 3, pp. 231–235, 2012. View at Publisher · View at Google Scholar
  7. F. Y. Kong, Q. Y. Zhang, Q. Guan, F. Q. Jian, W. Sun, and Y. Wang, “Effects of electroacupuncture on embryo implanted potential for patients with infertility of different symptom complex,” Zhong Guo Zhen Jiu, vol. 32, no. 2, pp. 113–116, 2012. View at Google Scholar
  8. T. Murotani, T. Ishizuka, H. Nakazawa et al., “Possible involvement of histamine, dopamine, and noradrenalin in the periaqueductal gray in electroacupuncture pain relief,” Brain Research, vol. 1306, pp. 62–68, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. H. Chen, X. K. Chen, and X. J. Yin, “Comparison of the therapeutic effects of electroacupuncture and probiotics combined with deanxit in treating diarrhea-predominant irritable bowel syndrome,” Zhong Guo Zhen Jiu, vol. 32, no. 5, pp. 594–598, 2012. View at Google Scholar
  10. J. Xing, B. Larive, N. Mekhail, and E. Soffer, “Transcutaneous electrical acustimulation can reduce visceral perception in patients with the irritable bowel syndrome: a pilot study,” Alternative Therapies in Health and Medicine, vol. 10, no. 1, pp. 38–42, 2004. View at Google Scholar · View at Scopus
  11. J. A. Christianson and G. F. Gebhart, “Assessment of colon sensitivity by luminal distension in mice.,” Nature Protocols, vol. 2, no. 10, pp. 2624–2631, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. E. H. Kamp, R. C. W. Jones, S. R. Tillman, and G. F. Gebhart, “Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 284, no. 3, pp. G434–G444, 2003. View at Google Scholar · View at Scopus
  13. M. J. Kim, U. Namgung, and K. E. Hong, “Regenerative effects of moxibustion on skeletal muscle in collagen-induced arthritic mice,” Journal of Acupuncture and Meridian Studies, vol. 5, no. 3, pp. 126–135, 2012. View at Google Scholar
  14. M. J. Kim, U. K. Namgung, and K. E. Hong, “Regenerative effects of moxibustion on skeletal muscle in collagen-induced arthritic mice,” Acupuncture and Meridian Studies, vol. 5, no. 6, pp. 126–135, 2012. View at Publisher · View at Google Scholar
  15. J. S. Han, “Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies,” Trends in Neurosciences, vol. 26, no. 1, pp. 17–22, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Xu, A. Liu, and X. Liu, “Aldosterone induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules,” Nephrology, vol. 13, no. 8, pp. 694–701, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Y. Xu, J. H. Winston, and J. D. Z. Chen, “Electroacupuncture attenuates visceral hyperalgesia and inhibits the enhanced excitability of colon specific sensory neurons in a rat model of irritable bowel syndrome,” Neurogastroenterology and Motility, vol. 21, no. 12, pp. 1302–e125, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. J. H. Sun, X. L. Wu, C. Xia, L. X. Pei, H. Li, and G. Y. Han, “Clinical evaluation of Soothing Gan and invigorating Pi acupuncture treatment on diarrhea-predominant irritable bowel syndrome,” Chinese Journal of Integrative Medicine, vol. 17, no. 10, pp. 780–785, 2011. View at Google Scholar
  19. L. L. Wu, C. H. Su, and C. F. Liu, “Effects of noninvasive electroacupuncture at Hegu (LI4) and Sanyinjiao (SP6) acupoints on dysmenorrhea: a randomized controlled trial,” Journal of Alternative and Complementary Medicine, vol. 18, no. 2, pp. 137–142, 2012. View at Publisher · View at Google Scholar
  20. R. Taguchi, T. Taguchi, and H. Kitakoji, “Involvement of peripheral opioid receptors in electroacupuncture analgesia for carrageenan-induced hyperalgesia,” Brain Research C, vol. 1355, pp. 97–103, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. R. C. W. Jones III, E. Otsuka, E. Wagstrom, C. S. Jensen, M. P. Price, and G. F. Gebhart, “Short-term sensitization of colon mechanoreceptors is associated With long-term hypersensitivity to colon distention in the mouse,” Gastroenterology, vol. 133, no. 1, pp. 184–194, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Shinoda, B. Feng, and G. F. Gebhart, “Peripheral and central P2X3 receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse,” Gastroenterology, vol. 137, no. 6, pp. 2096–2104, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. Chen, Y. Yan, K. Wang, W. Xu, and T. Shi, “An analysis of neuronal responses in nucleus centrum medianum to electrical stimulation of the superficial peroneal nerve.,” Zhen ci Yan Jiu, vol. 16, no. 1, pp. 15–47, 1991. View at Google Scholar · View at Scopus
  24. L. Yu, F. Yang, H. Luo et al., “The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant,” Molecular Pain, vol. 4, p. 61, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Luo, J. Cheng, J. S. Man, and Y. Wan, “Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats,” NeuroReport, vol. 15, no. 4, pp. 655–658, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Matsumoto, E. Kurosawa, H. Terui et al., “Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 297, no. 2, pp. G348–G360, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Yiangou, P. Facer, N. H. C. Dyer et al., “Vanilloid receptor 1 immunoreactivity in inflamed human bowel,” The Lancet, vol. 357, no. 9265, pp. 1338–1339, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. C. L. H. Chan, P. Facer, J. B. Davis et al., “Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency,” The Lancet, vol. 361, no. 9355, pp. 385–391, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. R. R. Ji, H. Baba, G. J. Brenner, and C. J. Woolf, “Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity,” Nature Neuroscience, vol. 2, no. 12, pp. 1114–1119, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. X. J. Zhang, H. L. Chen, Z. Li et al., “Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A1 receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway,” Pharmacology Biochemistry and Behavior, vol. 94, no. 1, pp. 88–97, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Galan, F. Cervero, and J. M. A. Laird, “Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain,” Molecular Brain Research, vol. 116, no. 1-2, pp. 126–134, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. R. R. Ji, K. Befort, G. J. Brenner, and C. J. Woolf, “ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity,” Journal of Neuroscience, vol. 22, no. 2, pp. 478–485, 2002. View at Google Scholar · View at Scopus
  33. A. Akbar, Y. Yiangou, P. Facer, J. R. F. Walters, P. Anand, and S. Ghosh, “Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain,” Gut, vol. 57, no. 7, pp. 923–929, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. M. M. Li, Y. Q. Yu, H. Fu, F. Xie, L. X. Xu, and J. Chen, “Extracellular signal-regulated kinases mediate melittin-induced hypersensitivity of spinal neurons to chemical and thermal but not mechanical stimuli,” Brain Research Bulletin, vol. 77, no. 5, pp. 227–232, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Chen, H. H. Willcockson, and J. G. Valtschanoff, “Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis,” Osteoarthritis and Cartilage, vol. 17, no. 2, pp. 244–251, 2009. View at Publisher · View at Google Scholar · View at Scopus