Table 1: The combination index of herceptin and curcumin treatment of the growth of BT-474 cells.

Herceptin (μg/mL)Curcumin (μg/mL)FaCIEffect

0.150.340.669Synergistic
0.1100.450.836Synergistic
0.1150.540.900Synergistic
150.520.393Synergistic
1100.520.713Synergistic
1150.540.953Synergistic
250.520.467Synergistic
2100.530.750Synergistic
2150.541.013Additive
550.50.794Synergistic
5100.521.007Additive
5150.561.075Additive
1050.491.354Antagonistic
10100.541.195Antagonistic
10150.571.241Antagonistic

A value of CI <1 represents a case where synergism of herceptin and curcumin was present. CI values of 1 and >1 represent additive and antagonistic effects, respectively. Fa, fraction affected; CI, combination index.