The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin

Table 1

The combination index of herceptin and curcumin treatment of the growth of BT-474 cells.

Herceptin (μg/mL)	Curcumin (μg/mL)	Fa	CI	Effect
0.1	5	0.34	0.669	Synergistic
0.1	10	0.45	0.836	Synergistic
0.1	15	0.54	0.900	Synergistic
1	5	0.52	0.393	Synergistic
1	10	0.52	0.713	Synergistic
1	15	0.54	0.953	Synergistic
2	5	0.52	0.467	Synergistic
2	10	0.53	0.750	Synergistic
2	15	0.54	1.013	Additive
5	5	0.5	0.794	Synergistic
5	10	0.52	1.007	Additive
5	15	0.56	1.075	Additive
10	5	0.49	1.354	Antagonistic
10	10	0.54	1.195	Antagonistic
10	15	0.57	1.241	Antagonistic

A value of CI <1 represents a case where synergism of herceptin and curcumin was present. CI values of 1 and >1 represent additive and antagonistic effects, respectively. Fa, fraction affected; CI, combination index.