Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 7

Research Article

Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

Figure 7

Effect of GAE on different angiogenic parameters in indomethacin-induced ulcerated mice. (a) von Willebrand Factor VIII; (b) mucosal VEGF level; (c) mucosal HGF level. Ulceration in the mice was induced by indomethacin (18โ€‰mg /kg, single dose, p. o.). Treatment was carried out for 3 days with GAE (5โ€‰mg/kg, single dose daily ร— 3 days, p. o.) or omeprazole (3โ€‰mg/kg, p. o.) after ulcer induction. The mucosal von Willebrand Factor VIII (expressed as number of microvessels/mm2) and growth factors (expressed as ng/ml tissue extract) were measured by immunohistochemistry and colorimetry, respectively. * ๐‘ƒ < 0 . 0 5 , ** ๐‘ƒ < 0 . 0 1 , compared to normal mice; # ๐‘ƒ < 0 . 0 1 , *** ๐‘ƒ < 0 . 0 0 1 , compared to untreated mice.
(a) โ€‰

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