Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

Table 1

Effect of UL_EtOH on the concentration (ng/g tissue) of monoamines and their metabolites in the cortex of mice brain.

Groups	Cortex (ng/g tissue)
	NE	MHPG	DA	DOPAC	5-HT	5-HIAA
Normal	525.96±43.71	280.41±12.76	735.26±53.40	625.26±63.78	438.75±36.89	372.32±18.22
Control versus FST	168.49±17.15^###	119.06±13.32^#	596.01±27.13	530.69±49.32	216.67±25.11^##	143.76±31.54^###
Imipramine 10 mg/kg	583.92±28.9 ***	233.37±59.00	701.97±56.63	411.47±49.71	711.42±63.27 ***	342.13±18.26 **
ULEtOH 0.125 g/kg	146.39±10.11	176.81±29.29	834.17±55.66	395.71±26.67	346.30±8.91	167.40±31.30
ULEtOH 0.25 g/kg	292.78±26.93 *	145.86±18.35	695.69±29.25	433.10±16.43	499.49±19.78 ***	165.02±46.22
ULEtOH 0.5 g/kg	320.69±20.16 **	273.19±58.11 *	622.98±67.15	577.92±88.01	639.27±49.86 ***	311.63±23.23 **

Values were the mean ± SEM (𝑛=6). ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001 as compared with the normal group. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 as compared with the control versus FST group (one-way ANOVA following by Bonferroni’s test).