Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 2

Research Article

Depression, Comorbidities, and Prescriptions of Antidepressants in a German Network of GPs and Specialists with Subspecialisation in Anthroposophic Medicine: A Longitudinal Observational Study

Table 2

Top 10 of prescribed antidepressants.

RankSubstanceATCType %Cum %

1Hypericum perforatum N06AP Phytoceutical1118044.644.6
2AmitriptylineN06AA09NSMRI42616.160.7
3MirtazapineN06AX11NaSSA2007.668.3
4CitalopramN06AB04SSRI1977.475.7
5DoxepinN06AA12NSMRI1405.381.0
6OpipramolN06AA05TCAs21043.985.0
7VenlafaxineN06AX16SSNRI692.687.6
8TrimipramineN06AA06NSMRI522.089.5
9FluoxetineN06AB03SSRI511.991.5
10ParoxetineN06AB05SSRI461.793.2
11–28Other < 1.7%31389.4100.0

Total2645100.0100.0

MAOIs: nonselective, monoamine oxidase A inhibitors; NaSSAs: noradrenergic and specific serotonergic antidepressants; NSMRIs: non-selective monoamine reuptake inhibitors; TCAs: tricyclic antidepressants; SSRIs: selective serotonin reuptake inhibitors; SSNRIs: selective serotonin and noradrenergic reuptake inhibitors.
1Two of the primary active constituents of Hypericum perforatum are hyperforin and adhyperforin. Hyperforin and adhyperforin are wide-spectrum inhibitors of the reuptake of serotonin, noradrenaline, glutamate, dopamine, and GABA.
2Although opipramol is a member of the tricyclic antidepressants, today it is typically used in the treatment of generalized anxiety disorders (GAD).
3Others drugs: for example, Bupropion (NDRIs: noradrenergic and dopaminergic reuptake inhibitors) and nefazodone (DSAs: dual serotonergic antidepressants).

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