|MAOIs: nonselective, monoamine oxidase A inhibitors; NaSSAs: noradrenergic and specific serotonergic antidepressants; NSMRIs: non-selective monoamine reuptake inhibitors; TCAs: tricyclic antidepressants; SSRIs: selective serotonin reuptake inhibitors; SSNRIs: selective serotonin and noradrenergic reuptake inhibitors.|
1Two of the primary active constituents of Hypericum perforatum are hyperforin and adhyperforin. Hyperforin and adhyperforin are wide-spectrum inhibitors of the reuptake of serotonin, noradrenaline, glutamate, dopamine, and GABA.
2Although opipramol is a member of the tricyclic antidepressants, today it is typically used in the treatment of generalized anxiety disorders (GAD).
3Others drugs: for example, Bupropion (NDRIs: noradrenergic and dopaminergic reuptake inhibitors) and nefazodone (DSAs: dual serotonergic antidepressants).