Gastric Ulcers in Middle-Aged Rats: The Healing Effect of Essential Oil from Citrus aurantium L. (Rutaceae)

Table 2

Counting of cells stained with specific antigen and neutrophils in the tissue regeneration of gastric ulcer induced by acetic acid in middle-aged rats (aged 12 months) after treatment with essential oil (OEC) of Citrus aurantium.

Treatment; (p.o.)	Doses; (mg/kg)	Neutrophils; (cells/mm^2)	Cells stained with specific antigen
			PCNA	HSP-70	COX-2	VEGF
Negative; control	—	1.82 ± 0.29	6.67 ± 0.32*	10.23 ± 1.19**	2.54 ± 0.49	2.87 ± 0.30
Positive; control	100	1.57 ± 0.20	5.30 ± 0.40	4.86 ± 0.43	2.44 ± 0.29	3.08 ± 0.40***
OEC	250	1.38 ± 0.27	4.17± 0.30	7.40 ± 0.43*	3.15 ± 0.47	6.07 ± 0.33***

Results are mean ± SEM. ANOVA followed by Dunnett’s test (𝑛=14-15). *P < 0.05, **P < 0.01, and ***P <0.001.