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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 510391, 6 pages
Research Article

Biological Effect of Leaf Aqueous Extract of Caesalpinia pyramidalis in Goats Naturally Infected with Gastrointestinal Nematodes

1Escola de Medicina Veterinária, Universidade Federal da Bahia, 40170-000 Salvador, BA, Brazil
2Programa de Pós-Graduação em Biotecnologia Industrial, Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, 49032-490 Aracaju, SE, Brazil
3Centro de Pesquisa Gonçalo Moniz-FIOCRUZ, 40296-710 Salvador, BA, Brazil
4Empresa Baiana de Desenvolvimento Agrícola, 41635-150 Salvador, BA, Brazil
5Instituto de Química, Universidade Federal da Bahia, 40170-290 Salvador, BA, Brazil
6Faculdade de Farmácia, Universidade Federal da Bahia, 41.170-280, Salvador, BA, Brazil

Received 27 October 2011; Revised 19 January 2012; Accepted 20 January 2012

Academic Editor: Vincenzo De Feo

Copyright © 2012 Roberto Robson Borges-dos-Santos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Forty-eight goats naturally infected with gastrointestinal nematodes were randomly divided into four groups ( ): negative control (G1) (untreated), positive control (G2) (treated with doramectin, 1 mL/50 Kg b.w.), and G3 and G4 treated with 2.5 and 5 mg/Kg b.w. of a leaf aqueous extract of Caesalpinia pyramidalis (CP). Fecal and blood samples were regularly collected for the evaluation of fecal egg count (FEC), hematological and immunological parameters to assess the anthelmintic activity. In treated animals with CP, there was noted a significant reduction of 54.6 and 71.2% in the mean FEC ( ). An increase in IgA levels was observed in G3 and G4 ( ), during the experimental period, suggesting that it was stimulated by the extract administration. In conclusion, the results showed that CP provoked a protective response in infected animals treated with them. This response could be partly explained by the CP chemical composition.