Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 515901, 11 pages
http://dx.doi.org/10.1155/2012/515901
Research Article

Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells

1Research Institute of Life science and College of Veterinary Medicine, Gyeongsang National University, Gazwa, Jinju 660-701, Republic of Korea
2Korea National Animal Research Resource Center and Korea National Animal Bio-resource Bank, Gyeongsang National University, Gazwa, Jinju 660-701, Republic of Korea
3Department of Nursing Science, International University of Korea, Jinju 660-759, Republic of Korea
4Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine and Gyeongnam Regional Cancer Center, Gyeongsang National University Hospital, Jinju 660-702, Republic of Korea
5Clinical Research Institute, Gyeongsang National University Hospital, Jinju 660-702, Republic of Korea

Received 5 August 2011; Accepted 14 September 2011

Academic Editor: Jae Youl Cho

Copyright © 2012 Do-Hoon Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. M. Ghobrial, T. E. Witzig, and A. A. Adjei, “Targeting apoptosis pathways in cancer therapy,” Ca-A Cancer Journal for Clinicians, vol. 55, no. 3, pp. 178–194, 2005. View at Google Scholar · View at Scopus
  2. F. Deyhim, E. Lopez, J. Gonzalez, M. Garcia, and B. S. Patil, “Citrus juice modulates antioxidant enzymes and lipid profiles in orchidectomized rats,” Journal of Medicinal Food, vol. 9, no. 3, pp. 422–426, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. S. Kim, J. S. Baik, T. H. Oh, W. J. Yoon, N. H. Lee, and C. G. Hyun, “Biological activities of Korean Citrus obovoides and Citrus natsudaidai essential oils against acne-inducing bacteria,” Bioscience, Biotechnology and Biochemistry, vol. 72, no. 10, pp. 2507–2513, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Li, H. Fang, and W. Xu, “Recent advance in the research of flavonoids as anticancer agents,” Mini-Reviews in Medicinal Chemistry, vol. 7, no. 7, pp. 663–678, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Quílez, B. Berenguer, G. Gilardoni et al., “Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav,” Journal of Ethnopharmacology, vol. 128, no. 3, pp. 583–589, 2010. View at Publisher · View at Google Scholar
  6. C. D. Harapu, A. Miron, M. Cuciureanu, and R. Cuciureanu, “Flavonoids—bioactive compounds in fruits juice,” Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti din Lasi, vol. 114, pp. 1209–1214, 2010. View at Google Scholar
  7. Y. C. Hsiao, Y. S. Hsieh, W. H. Kuo et al., “The tumor-growth inhibitory activity of flavanone and 2′-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs,” Journal of Biomedical Science, vol. 14, no. 1, pp. 107–119, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Luo, X. Guan, and L. Zhou, “Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo.,” Cancer Biology & Therapy, vol. 7, no. 6, pp. 966–973, 2008. View at Google Scholar · View at Scopus
  9. J. R. Patil, K. N. Chidambara Murthy, G. K. Jayaprakasha, M. B. Chetti, and B. S. Patil, “Bioactive compounds from mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells,” Journal of Agricultural and Food Chemistry, vol. 57, no. 22, pp. 10933–10942, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. K. D. Crew and A. I. Neugut, “Epidemiology of gastric cancer,” World Journal of Gastroenterology, vol. 12, no. 3, pp. 354–362, 2006. View at Google Scholar · View at Scopus
  11. S. A. Hundahl, J. L. Phillips, and H. R. Menck, “The national cancer data base report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy: fifth edition American joint committee on cancer staging, proximal disease, and the “different disease” hypothesis,” Cancer, vol. 88, no. 4, pp. 921–932, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Jin and W. S. El-Deiry, “Overview of cell death signaling pathways,” Cancer Biology and Therapy, vol. 4, no. 2, pp. 139–163, 2005. View at Google Scholar · View at Scopus
  13. H. R. Stennicke and G. S. Salvesen, “Caspases—Controlling intracellular signals by protease zymogen activation,” Biochimica et Biophysica Acta, vol. 1477, no. 1-2, pp. 299–306, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Lindsay, M. D. Esposti, and A. P. Gilmore, “Bcl-2 proteins and mitochondria-specificity in membrane targeting for death,” Biochimica et Biophysica Acta, vol. 1813, pp. 532–539, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Li, D. Nijhawan, I. Budihardjo et al., “Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade,” Cell, vol. 91, no. 4, pp. 479–489, 1997. View at Google Scholar · View at Scopus
  16. T. M. Guadagno, M. Ohtsubo, J. M. Roberts, and R. K. Assoian, “A link between cyclin A expression and adhesion-dependent cell cycle progression,” Science, vol. 262, no. 5139, pp. 1572–1575, 1993. View at Google Scholar · View at Scopus
  17. R. W. King, P. K. Jackson, and M. W. Kirschner, “Mitosis in transition,” Cell, vol. 79, no. 4, pp. 563–571, 1994. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Krek and E. A. Nigg, “Differential phosphorylation of vertebrate p34(cdc2) kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites,” EMBO Journal, vol. 10, no. 2, pp. 305–316, 1991. View at Google Scholar · View at Scopus
  19. K. I. Park, H. S. Park, S. R. Kang et al., “Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells,” Journal of Ethnopharmacology, vol. 133, pp. 634–641, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Xu, X. Chen, Q. Zhang, L. Chen, and Y. Wang, “Corydalis yanhusuo W.T. Wang extract inhibits MCF-7 cell proliferation by inducing cell cycle G2/M arrest,” American Journal of Chinese Medicine, vol. 39, no. 3, pp. 579–586, 2011. View at Publisher · View at Google Scholar
  21. Y. J. Moon, X. Wang, and M. E. Morris, “Dietary flavonoids: effects on xenobiotic and carcinogen metabolism,” Toxicology in Vitro, vol. 20, no. 2, pp. 187–210, 2006. View at Publisher · View at Google Scholar
  22. R. Pierini, J. M. Gee, N. J. Belshaw, and I. T. Johnson, “Flavonoids and intestinal cancers,” British Journal of Nutrition, vol. 99, no. 1, pp. ES53–ES59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. K. N. Chidambara Murthy, G. K. Jayaprakasha, V. Kumar, K. S. Rathore, and B. S. Patil, “Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis,” Journal of Agricultural and Food Chemistry, vol. 59, no. 6, pp. 2314–2323, 2011. View at Publisher · View at Google Scholar
  24. M. O. Hengartner, “The biochemistry of apoptosis,” Nature, vol. 407, no. 6805, pp. 770–776, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Y. Jin, Y. H. Choi, D. O. Moon et al., “Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei,” Oncology Reports, vol. 16, no. 6, pp. 1349–1355, 2006. View at Google Scholar · View at Scopus
  26. Y. Wang, P. Ji, J. Liu, R. R. Broaddus, F. Xue, and W. Zhang, “Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy,” Molecular Cancer, vol. 8, article 8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Vidya Priyadarsini, R. Senthil Murugan, S. Maitreyi, K. Ramalingam, D. Karunagaran, and S. Nagini, “The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition,” European Journal of Pharmacology, vol. 649, no. 1–3, pp. 84–91, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Han, C. Zhong, X. Zhang et al., “Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells,” Nutrition and Cancer, vol. 62, no. 5, pp. 641–647, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. S. M. Lee, J. I. Kwon, Y. H. Choi, H. S. Eom, and G. Y. Chi, “Induction of G2/M arrest and apoptosis by water extract of Strychni Semen in human gastric carcinoma AGS cells,” Phytotherapy Research, vol. 22, no. 6, pp. 752–758, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. S. Hwang, W.-Y. Chung, J. Kim, H.-J. Park, E.-C. Kim, and K.-K. Park, “Buddlejasaponin IV induces cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes,” Phytotherapy Research, vol. 25, no. 10, pp. 1503–1510, 2011. View at Publisher · View at Google Scholar
  31. B. Wu, Q. Zhang, W. Shen, and J. Zhu, “Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line,” Molecular and Cellular Biochemistry, vol. 313, no. 1-2, pp. 125–132, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Y. Xiao, M. Hao, X. Y. Yang et al., “Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis,” Cancer Letters, vol. 302, pp. 69–75, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. A. H. Wyllie, “Apoptosis (The 1992 Frank Rose Memorial Lecture),” British Journal of Cancer, vol. 67, no. 2, pp. 205–208, 1993. View at Google Scholar · View at Scopus
  34. M. Olsson and B. Zhivotovsky, “Caspases and cancer,” Cell Death and Differentiation, vol. 18, pp. 1441–1449, 2011. View at Publisher · View at Google Scholar
  35. G. M. Cohen, “Caspases: the executioners of apoptosis,” Biochemical Journal, vol. 326, no. 1, pp. 1–16, 1997. View at Google Scholar · View at Scopus
  36. T. S. Zheng, S. Hunot, K. Kuida et al., “Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation,” Nature Medicine, vol. 6, no. 11, pp. 1241–1247, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. A. Lazebnik, S. H. Kaufmann, S. Desnoyers, G. G. Poirier, and W. C. Earnshaw, “Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE,” Nature, vol. 371, no. 6495, pp. 346–347, 1994. View at Publisher · View at Google Scholar · View at Scopus
  38. H. W. Findley, L. Gu, A. M. Yeager, and M. Zhou, “Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia,” Blood, vol. 89, no. 8, pp. 2986–2993, 1997. View at Google Scholar · View at Scopus
  39. C. Y. Jin, C. Park, J. Cheong et al., “Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3,” Cancer Letters, vol. 257, no. 1, pp. 56–64, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. M.-J. Kim, D.-H. Kim, H.-K. Na, T. Y. Oh, C.-Y. Shin, and Y.-J. Surh, “Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 24, no. 4, pp. 261–269, 2005. View at Google Scholar