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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 534219, 7 pages
Review Article

Patch Clamp: A Powerful Technique for Studying the Mechanism of Acupuncture

1Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China
2Shanghai Research Center for Acupuncture and Meridians, Shanghai 201203, China

Received 13 August 2012; Accepted 18 September 2012

Academic Editor: Guang-hong Ding

Copyright © 2012 D. Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cellular and molecular events can be investigated using electrophysiological techniques. In particular, the patch-clamp method provides detailed information. In addition, the patch-clamp technique has become a powerful method for investigating the mechanisms underlying the effects of acupuncture. In this paper, recent researches on how acupuncture might modulate electrophysiological responses in the central nervous system (CNS) and affect peripheral structures are reviewed.