Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete Freund's Adjuvant-Induced Inflammatory Pain
Effect of EA on phosphor-p38MAPK-immunoreactivty (p-p38MAPK-IR) expression in the ipsilateral spinal dorsal horn induced in CFA rats. (a) Representative sections of p-p38MAPK-IR cells in the ipsilateral spinal dorsal horn at postinjection days 3 and 14. (section 1, saline group; sections 2 and 4, CFA group, sections 3 and 5, CFA + EA group; sections 2 and 3, postinjection day 3; sections 4 and 5, postinjection day 14; Bars = 50 μm; section thickness = 30 μm). (b) Quantification of p-p38MAPK-IR showing that EA suppressed p-p38MAPK-IR expression in the ipsilateral spinal dorsal horn. Values are mean ± SD, animals per experimental group. ** versus saline group; ▲▲ versus CFA group at corresponding time points.
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