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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 578497, 12 pages
http://dx.doi.org/10.1155/2012/578497
Research Article

Antioxidant and Protective Effects of Bupleurum falcatum on the L-Thyroxine-Induced Hyperthyroidism in Rats

1Department of Oriental Internal Medicine of Hepatology, College of Oriental Medicine and Daegu Haany University, Gyeongsan 712-715, Republic of Korea
2Department of Herbal Formulation, College of Oriental Medicine and Daegu Haany University, Gyeongsan 712-715, Republic of Korea
3The Medical Research Center for Globalization of Herbal Formulation, Daegu Haany University, Gyeongsan 712-715, Republic of Korea
4Department of Neurology, College of Oriental Medicine and Daegu Haany University, Gyeongsan 712-715, Republic of Korea
5Department of Internal Medicine, College of Oriental Medicine and Daegu Haany University, Gyeongsan 712-715, Republic of Korea
6Department of Histology and Anatomy, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea

Received 13 May 2012; Accepted 3 June 2012

Academic Editor: Il-Moo Chang

Copyright © 2012 Seong-Mo Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes. The effects of BR extracts were compared with that of propylthiouracil, a standard antithyroid drug 10 mg/kg (intraperitoneally). In this experiment, BR extracts dose dependently reversed LT4-induced hyperthyroidisms, and these effects indicating their potential in the regulation of hyperthyroidism. Further, the BR extract normalized LT4-induced liver oxidative stresses, and also reduced liver and epididymal fat pad changes. BR extracts 150 mg/kg showed comparable effects on the LT4-induced rat hyperthyroidism as compared with PTU 10 mg/kg. These effects of BR may help the improvement of hyperthyroidisms and accompanied various organ damages.