Antioxidant and Protective Effects of Bupleurum falcatum on the L-Thyroxine-Induced Hyperthyroidism in Rats

Figure 3

Representative histopathological profiles on the thyroid glands of intact control (a, b), LT4 control (c, d), PTU 10 mg/kg (e, f), BR 300 (g, h), 150 (i, j), and 75 (k, l) mg/kg treated rats. LT4 treatment-related thyroid gland atrophic changes were dramatically inhibited by PTU 10 mg/kg and all three different dosages of BR-treated rats as compared with LT4 control rats. BR: aqueous Bupleuri Radix extracts; LT4: levothyroxine; PTU: propylthiouracil; FO: follicle; PT: parathyroid glands. All H&E stain; scale bars = 80 μm.

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